DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmtc3 and tmtc3

DIOPT Version :9

Sequence 1:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	XP_001922486.4	Gene:	tmtc3 / 100150181	ZFINID:	ZDB-GENE-061221-2	Length:	932	Species:	Danio rerio

Alignment Length:	888	Identity:	449/888 - (50%)
Similarity:	590/888 - (66%)	Gaps:	46/888 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LCICVACIV-CYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSYRPL 101
            :|:....:| ||:||..||.||||:|||.|||||||.|||.|:||||||||||.:|:||||||||
Zfish     9 ICLLTGLVVGCYWNSLFCGFVFDDVSAILDNKDLRPTTPLKNLFLNDFWGTPMSEERSHKSYRPL 73

  Fly   102 TVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSVSQLN 166
            ||||||.|||...|....|||:|::||..||:|:...|||||.:
Zfish    74 TVLTFRLNYLFSELNSSSYHLLNVVLHAVVCVLFLHFCRLLLDR--------------------- 117

  Fly   167 TCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTNWLTLFGCFG 231
            :.:.:|:|||||||:||||||||||||||||||..|||||:|.||   .|......|..:.....
Zfish   118 STSLIATLLFAVHPIHTEAVTGVVGRAELLSSIFLLAAFLAYTKS---KGTDHSIVWTPIISTVF 179

  Fly   232 SCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLANPSGIRRWS 296
            ...:|: ||||||||:.|||.:||:||........|...:|::           |....|.....
Zfish   180 LVAVAT-LCKEQGITVIGICCIYEVFVAQGFTLPMLIDTLLQV-----------LRGKDGFPYAV 232

  Fly   297 SSTLWKRLSFLVGITLTLLVGRVYVMGSQLPIFTRFDNPASAADTPERQLTYGYLIYLNCWLLLC 361
            ..||.|.:..::. ||.|::.||.|:.||||:||||||||:.:.||.||||:.||:.:|.||||.
Zfish   233 LQTLLKLIVLIIS-TLLLVIIRVQVIQSQLPVFTRFDNPAAVSSTPSRQLTFNYLLPVNAWLLLN 296

  Fly   362 PSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAKTCFTRNLALSRTLIMCLGWMVLPFL 426
            ||.|||||||||:||::...||||:.||:.:..|| ::|......|.:.|:.::|.|..:||||:
Zfish   297 PSELCCDWTMGTIPLVESLLDSRNLATLVFYTFLG-LLAYHGLWYNHSSSKIIMMALSLIVLPFI 360

  Fly   427 PASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSWQRFSQAALAILLLTHALKTHQ 491
            ||||||||||||||||:||:||||:|:||||||:.|.::|.|  ::.|...:.|||.|||:||..
Zfish   361 PASNLFFPVGFVVAERVLYVPSMGFCVLVAYGFKLLSQKGGL--KKMSWLLMGILLTTHAVKTFN 423

  Fly   492 RNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGR 556
            ||.||.:||:||.|.:.||:.||||:|||||||||:..:|.||.||.||.|:|.||||||:||||
Zfish   424 RNWDWESEYTLFTSALKVNRNNAKLWNNVGHALENQNSYERALRYFLQATRVQPDDIGAHMNVGR 488

  Fly   557 TFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLEEADHLYR 621
            |:.||.|..|||:||:.||:|.||..||..|..|:|||||||:|||||||..|.:||||||.|||
Zfish   489 TYKNLNRSREAEEAYLIAKSLMPQIIPGKKYATRVAPNHLNVYINLANLIRANDSRLEEADQLYR 553

  Fly   622 QAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQGKSQQAQV 686
            ||||||.|:.||||:||::|:|:|:.::|::.|.:||..|:.|||::|||.:|.:|.....:|..
Zfish   554 QAISMRPDFKQAYISRGELLLKMNKPSEAKDAYLRALELDHTNADLWYNLAIVNIEMKDPSEALR 618

  Fly   687 YFNKAIELYPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESS 751
            .||:|::|.|.|:.||.|||:|:||.|..:.|..:..|....::.:..:...||||||||||.:.
Zfish   619 NFNRALDLNPRHKLALFNSALLMQESGEAKLRPEANRRFLTYVKEEPDDANGYFNLGMLAMDANE 683

  Fly   752 FDEAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYIN 816
            .:|||.:.:.||||:..|||||||||||.:.::|.|||:|.|.:|:|:||.|||||||.|||.:|
Zfish   684 NEEAEHWMREAIHLQPGFRSALFNLALLYSQSQRELDALPVLEELLRYHPEHVKGLILKGDILMN 748

  Fly   817 HMKDLDEAEKCYRSILHYDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAEDYIGRHLQI 881
            |.||...|:.|:..||..||.|.|..||||||:.|.:.|.:|..||.....:||.|:||.|||.|
Zfish   749 HRKDTRGAKTCFERILSMDPSNVQAKHNLCVVYFEERELQRAERCLVDTLAMAPQEEYIRRHLAI 813

  Fly   882 VLARLQKINKLPESAPERKLAYEDYDPLEFKLPQDRPTHKSRK 924
            |..::..:     ||..:.:|..:...:..|....:|..|..:
Zfish   814 VRNKMAAM-----SAAGQPIAPTEGGSMSDKQQGHQPEDKKEE 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859	44/72 (61%)
		PEP_TPR_lipo	<513..871	CDD:274350	193/357 (54%)
		TPR repeat	514..542	CDD:276809	19/27 (70%)
		TPR repeat	547..591	CDD:276809	26/43 (60%)
		TPR repeat	598..625	CDD:276809	20/26 (77%)
		TPR repeat	630..660	CDD:276809	13/29 (45%)
		TPR repeat	665..693	CDD:276809	11/27 (41%)
		TPR repeat	737..764	CDD:276809	14/26 (54%)
		TPR repeat	803..834	CDD:276809	18/30 (60%)
		TPR repeat	839..867	CDD:276809	12/27 (44%)
tmtc3	XP_001922486.4	DUF1736	258..331	CDD:285594	44/72 (61%)
		TPR_11	<434..477	CDD:290150	26/42 (62%)
		TPR repeat	445..475	CDD:276809	20/29 (69%)
		TPR_1	446..479	CDD:278916	21/32 (66%)
		TPR	462..757	CDD:223533	160/294 (54%)
		TPR repeat	480..506	CDD:276809	17/25 (68%)
		TPR repeat	530..557	CDD:276809	20/26 (77%)
		TPR repeat	562..592	CDD:276809	13/29 (45%)
		TPR_1	564..596	CDD:278916	14/31 (45%)
		TPR_1	597..630	CDD:278916	13/32 (41%)
		TPR repeat	597..625	CDD:276809	11/27 (41%)
		TPR repeat	667..697	CDD:276809	15/29 (52%)
		TPR repeat	702..730	CDD:276809	17/27 (63%)
		TPR repeat	736..765	CDD:276809	16/28 (57%)
		TPR_11	739..802	CDD:290150	29/62 (47%)
		TPR repeat	771..794	CDD:276809	10/22 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594811
Domainoid	1	1.000	228	1.000	Domainoid score	I2430
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27616
Inparanoid	1	1.050	846	1.000	Inparanoid score	I423
OMA	1	1.010	-	-		QHG45272
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	1	1.000	-	-		FOG0007335
OrthoInspector	1	1.000	-	-		oto39644
orthoMCL	1	0.900	-	-		OOG6_106603
Panther	1	1.100	-	-	LDO	PTHR44395
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4792
SonicParanoid	1	1.000	-	-		X4132
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840