DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ktub and TUB

DIOPT Version :9

Sequence 1:	NP_611549.2	Gene:	ktub / 37400	FlyBaseID:	FBgn0015721	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_003311.2	Gene:	TUB / 7275	HGNCID:	12406	Length:	561	Species:	Homo sapiens

Alignment Length:	519	Identity:	225/519 - (43%)
Similarity:	300/519 - (57%)	Gaps:	83/519 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GINSRNQKMEQQRQLMEAYIRQKRASPGMVQASDLQINRPMSGMRSNSRELHAYDGPM--QFISS 65
            |.|.|.||:::||.|:|...::||..|.||||:  ...||.|.....|.|    ..|:  .::||
Human    74 GRNLRQQKLDRQRALLEQKQKKKRQEPLMVQAN--ADGRPRSRRARQSEE----QAPLVESYLSS 132

  Fly    66 P-------QNPDQILTNGSPGGINPVAMNTSRN-----HSNNMRSLSTINQEGKWSYTPRKADLI 118
            .       |..|. |.:...|...|.|..:::.     .:......:...::||...|...|.|.
Human   133 SGSTSYQVQEADS-LASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALA 196

  Fly   119 EEISSHELEDEESSPVTVI----EQHQQSASHSA------------NSTQSQKPRARQHSFSDNL 167
            |:      :.|...||.::    ..|.|.|..:|            .:|..:|..:...||.::
Human   197 ED------KSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDED- 254

  Fly   168 DEDDYTN-------------RNVAGAAPVRPAGMASSPYKDATLDGSSNGTGNGTGGESEGDV-I 218
            :||:..|             .:......||.|..|.||                |..|...|| :
Human   255 EEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSP----------------TAPEQPVDVEV 303

  Fly   219 GNIDQFVMQPAPQGVLYKCRITRDRKGMDRGLFPIYYLHLERDYGKKIFLLGGRKRKKSKTSNYI 283
            .::::|.::|||||:..|||||||:||||||::|.|:|||:|:.|||:|||.||||||||||||:
Human   304 QDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYL 368

  Fly   284 VSCDPTDLSRNADGFCGKLRSNVFGTSFTVFDNG-NKESTESP-------RLDLAVIIYDTNILG 340
            :|.|||||||..|.:.||||||:.||.|||:||| |.:...|.       |.:||.:.|:||:||
Human   369 ISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLG 433

  Fly   341 FKGPRNMTVILPGMTEDDQRVKISSADPKQQGILDLWKMKNMDNIVELHNKTPVWNDETQSYVLN 405
            |||||.|:||:|||....:||.|...: :.:.:|..|:.||.::|:||.||||||||:|||||||
Human   434 FKGPRKMSVIVPGMNMVHERVSIRPRN-EHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLN 497

  Fly   406 FHGRVTQASVKNFQLVHDSDPEYIVMQFGRTSEDVFTMDYRYPLCAMQAFAIALSSFDGKIACE 469
            ||||||||||||||::|.:||:||||||||.:||||||||.|||||:|||||||||||.|:|||
Human   498 FHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ktub	NP_611549.2	Tub	228..462	CDD:279506	157/241 (65%)
TUB	NP_003311.2	Tub_N	84..292	CDD:292938	49/221 (22%)
TUB	NP_003311.2	Tub	313..554	CDD:279506	157/241 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1121
eggNOG	1	0.900	-	-		E1_KOG2502
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2142
Isobase	1	0.950	-	0	Normalized mean entropy	S3334
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1445357at2759
OrthoFinder	1	1.000	-	-		FOG0000431
OrthoInspector	1	1.000	-	-		otm41820
orthoMCL	1	0.900	-	-		OOG6_101683
Panther	1	1.100	-	-	LDO	PTHR16517
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2866
SonicParanoid	1	1.000	-	-		X288
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.810