Protein Alignment ktub and TULP4

DIOPT Version :10

• Sequence 1: NP_611549.2
• Gene: ktub / 37400
• FlyBaseID: FBgn0015721
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: XP_011534248.1
• Gene: TULP4 / 56995
• HGNCID: 15530
• Length: 1566
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 107/485 - (22%)
• Similarity: 183/485 - (37%)
• Gaps: 120/485 - (24%)

  Fly    19 EAYIRQKR----ASPGMVQASDLQINRPMSGMRSNSRELHAYDGPMQFIS--SPQNPDQILTNGS 77
            :.::.|:|    :.|..::.|.|.:          |:..|.....:.|||  ||.:|......|
Human  1154 DVWVPQERTAQTSGPNPLKLSSLML----------SQGQHLDVSRLPFISPKSPASPTATFQTG- 1207

  Fly    78 PGGINPVAMNTSRNHSNNMRSLSTINQEGKWSYTPRKADLIEEISSHELEDEESSPVTVIEQ-HQ 141
                  ..|......|.|...|..:..    ..:|:.|     :|..:...:|  |..|::. :.
Human  1208 ------YGMGVPYPGSYNNPPLPGVQA----PCSPKDA-----LSPTQFAQQE--PAVVLQPLYP 1255

  Fly   142 QSASH---------SANSTQSQKPRARQHSFSDNLDEDDYT----NRNVAGAAPVRPAGMASSPY 193
            .|.|:         |:..:..|.|....|.:|      .|:    .:|..|..|.:|..:...|.
Human  1256 PSLSYCTLPPMYPGSSTCSSLQLPPVALHPWS------SYSACPPMQNPQGTLPPKPHLVVEKPL 1314

  Fly   194 KDATLDGSSNGTGNGTGGESEGDVIGNIDQFVMQPAPQ-----GVLYKCRITRDRKGMDRGLFPI 253
            .........:..|.....|: .|....:......|.||     |       .::||.:|.
Human  1315 VSPPPADLQSHLGTEVMVET-ADNFQEVLSLTESPVPQRTEKFG-------KKNRKRLDS----- 1366

  Fly   254 YYLHLERDYGKKIFLLGGRKRKKSKT---SNYIVSC-----DPTDLSRNADGFCGKLRSNVFGTS 310
                 ..:.|....:..|:.:|:::|   .|.::|.     :...:....|    :|:|.....:
Human  1367 -----RAEEGSVQAITEGKVKKEARTLSDFNSLISSPHLGREKKKVKSQKD----QLKSKKLNKT 1422

  Fly   311 FTVFDNGNKESTES-PRLDLAVIIYDTNIL--------GFKGPRNMTVILPGMTEDDQRVKISSA 366
                 |..::|:|| |.|    .|....::        |:|..|:     |....:.:..|...|
Human  1423 -----NEFQDSSESEPEL----FISGDELMNQSQGSRKGWKSKRS-----PRAAGELEEAKCRRA 1473

  Fly   367 DPKQQGILDLWKMKNMDNIVELHNKTPVWNDETQSYVLNFHGRVTQASVKNFQLVHDSDPEYIVM 431
            ..|:.|     ::.:...:..:.||.|:||:.||.|.|:|.|||||.|.||||:..:...   ||
Human  1474 SEKEDG-----RLGSQGFVYVMANKQPLWNEATQVYQLDFGGRVTQESAKNFQIELEGRQ---VM 1530

  Fly   432 QFGRTSEDVFTMDYRYPLCAMQAFAIALSS 461
            ||||.....:.:|::||..|:||||:||::
Human  1531 QFGRIDGSAYILDFQYPFSAVQAFAVALAN 1560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ktub	NP_611549.2	Tub	226..464	CDD:460094	67/258 (26%)
TULP4	XP_011534248.1	WD40	<45..217	CDD:441893
		WD40 repeat	85..123	CDD:293791
		WD40 repeat	129..166	CDD:293791
		WD40 repeat	171..205	CDD:293791
		SOCS	396..431	CDD:470605
		Atrophin-1	1042..>1318	CDD:460830	37/197 (19%)
		Tub	<1489..1559	CDD:460094	35/72 (49%)