DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ktub and tulp3

DIOPT Version :9

Sequence 1:	NP_611549.2	Gene:	ktub / 37400	FlyBaseID:	FBgn0015721	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_005164515.1	Gene:	tulp3 / 566221	ZFINID:	ZDB-GENE-130530-714	Length:	490	Species:	Danio rerio

Alignment Length:	513	Identity:	222/513 - (43%)
Similarity:	289/513 - (56%)	Gaps:	108/513 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 INSRNQKMEQQRQLMEAYIRQKRASPGMVQASDLQINRPMSGMRSNSRE---------------- 52
            :|.|.||:|:||.|:|...|:||....|||.:  ...||.......|.|
Zfish    39 LNLRQQKLEKQRALLEQKQRRKRQELLMVQPN--PDGRPRRSRPRRSEEQAPLVETNISTASDII 101

  Fly    53 LHAYDGP--------------MQFISSPQNPDQILTNGSPGGINPVAMNTSRNHSNN-----MRS 98
            |...|||              :|.:|..|.|.|    .||    ||......:...:     ...
Zfish   102 LDGIDGPAALLGSEAPDLGSKIQVLSVSQTPQQ----PSP----PVTEEPETDADTDTLLEPKTD 158

  Fly    99 LSTINQ----EGKWSYTPRKADLIEEISSHELEDEESSPVTVIEQHQQSASHSANSTQSQKPRAR 159
            :.|:.|    .|..:|        :|.|..|.||:|      .|..::|.|.|.| |:|.:|
Zfish   159 IHTLLQRRGLSGSMNY--------DEASEDEDEDDE------YEAEERSRSLSPN-TESTRP--- 205

  Fly   160 QHSFSDNLDEDDYTNRNVAGAAPVRPAGMASSPYKDATLDGSSNGTGNGTGGESEGDVIGNIDQF 224
                                         ||:....:|.:....|:.:..|...|.|   |:::|
Zfish   206 -----------------------------ASASSTKSTTECIPVGSPSAEGSSIEVD---NLEEF 238

  Fly   225 VMQPAPQGVLYKCRITRDRKGMDRGLFPIYYLHLERDYGKKIFLLGGRKRKKSKTSNYIVSCDPT 289
            |::||||||..||||:||:|||||||:|.|::||||:.|||:|||.||||||||||||::|.|.|
Zfish   239 VLRPAPQGVTVKCRISRDKKGMDRGLYPTYFMHLEREDGKKVFLLAGRKRKKSKTSNYLISVDAT 303

  Fly   290 DLSRNADGFCGKLRSNVFGTSFTVFDNGNKESTE--------SPRLDLAVIIYDTNILGFKGPRN 346
            ||||..:.|.||||||:.||.|||:|||...|..        :.|.:||.|.|:||:|||||||.
Zfish   304 DLSREGESFIGKLRSNLMGTKFTVYDNGTNPSKNPGALLEETNTRQELAAICYETNVLGFKGPRK 368

  Fly   347 MTVILPGMTEDDQRVKISSADPKQQGILDLWKMKNMDNIVELHNKTPVWNDETQSYVLNFHGRVT 411
            ||||:|||....:||.:..|. :|:.:|..|:..:::|::|||||.|||||:|||||||||||||
Zfish   369 MTVIIPGMNMSFERVPVRPAS-EQESLLSKWQNHSLENLIELHNKAPVWNDDTQSYVLNFHGRVT 432

  Fly   412 QASVKNFQLVHDSDPEYIVMQFGRTSEDVFTMDYRYPLCAMQAFAIALSSFDGKIACE 469
            ||||||||:|||:||:||||||||.:||:||:||.||:||:|||||.|||||.|:|||
Zfish   433 QASVKNFQIVHDNDPDYIVMQFGRVAEDIFTLDYNYPMCALQAFAIGLSSFDSKLACE 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ktub	NP_611549.2	Tub	228..462	CDD:279506	155/241 (64%)
tulp3	XP_005164515.1	Tub_N	48..223	CDD:292938	49/231 (21%)
tulp3	XP_005164515.1	Tub	242..483	CDD:279506	155/241 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	344	1.000	Domainoid score	I1027
eggNOG	1	0.900	-	-		E1_KOG2502
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20711
Inparanoid	1	1.050	374	1.000	Inparanoid score	I2059
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1445357at2759
OrthoFinder	1	1.000	-	-		FOG0000431
OrthoInspector	1	1.000	-	-		otm24451
orthoMCL	1	0.900	-	-		OOG6_101683
Panther	1	1.100	-	-	O	PTHR16517
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2866
SonicParanoid	1	1.000	-	-		X288
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.860