DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ktub and si:dkey-220f10.4

DIOPT Version :9

Sequence 1:	NP_611549.2	Gene:	ktub / 37400	FlyBaseID:	FBgn0015721	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_003199647.1	Gene:	si:dkey-220f10.4 / 564717	ZFINID:	ZDB-GENE-030131-9651	Length:	556	Species:	Danio rerio

Alignment Length:	568	Identity:	207/568 - (36%)
Similarity:	305/568 - (53%)	Gaps:	111/568 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGINSRNQKMEQQRQLMEAYIRQKRASPGMVQASD-----------------LQINRPMSGMRS 48
            |.....|.||::.||.|:....:::||...||.|:.                 |.|::..|....
Zfish     1 MEDAEVRQQKLDNQRSLLIKKQQRRRADARMVTANPDICSKTRKQKPECDDTVLLISQSQSNTSL 65

  Fly    49 N-SRELHAYD--------GPMQFISSPQNPDQILTNGSPGGINPVAMNTSRNHSNNMRSLSTINQ 104
            | ::..|.|:        |.:...|..:...:.:....|..|..:.:..|..||    :.||::.
Zfish    66 NDTQPEHIYENTVEEICLGELSVSSRTEEASEEIAQTVPVIIKKIDLEISPKHS----TTSTLDT 126

  Fly   105 EG--------KWSYTPRKADLIEEISSHELEDEESSPVTVIEQHQ---------QSASHSANSTQ 152
            :|        |......:..|:|..::.|:|:.|......:::.:         ::...|:..|.
Zfish   127 DGQADEKKTKKKGVKKGQTKLLEPKAALEVEENEKKEKKSVKKKEKTNGTKGRAKTGEQSSVQTD 191

  Fly   153 S---------QKPRA--------------------------RQH---SFSDNLDEDDYTNRNVAG 179
            |         :||.:                          |.|   |..:|.::::...:..|.
Zfish   192 SVVDFSINEEKKPESESEDEGKDWSKSPVPPTPKKKQMKPMRCHLSDSEEENDEKEEKDKKKEAK 256

  Fly   180 AAP---------VRPAGMASSPYKDATLDGSSNGTGNGTGGESEGDVIGNIDQFVMQPAPQGVLY 235
            ..|         |......:|.||:.:.|..|:..|..:....|     :::||.|:|||:.|..
Zfish   257 KTPKKSKKNTKSVNSLASLNSNYKEHSSDSDSSDIGKSSPMSLE-----DLEQFAMRPAPRDVTI 316

  Fly   236 KCRITRDRKGMDRGLFPIYYLHLERDYGKKIFLLGGRKRKKSKTSNYIVSCDPTDLSRNADGFCG 300
            :|||||||:|:::|::|.||||:|::.||::||:.||||||.|||||::|.|||||||:.|.:.|
Zfish   317 QCRITRDRRGVEKGIYPTYYLHMEKEDGKRVFLMAGRKRKKCKTSNYLISVDPTDLSRDTDSYIG 381

  Fly   301 KLRSNVFGTSFTVFDNGNK-------ESTESPRLDLAVIIYDTNILGFKGPRNMTVILPGMTEDD 358
            ||||||.||.|||||||..       :..::.|.:||.|.|:.|:|||||||.||||:|||.|:|
Zfish   382 KLRSNVLGTKFTVFDNGENPERKPFIKEMDTLRQELAAIFYEKNVLGFKGPRKMTVIIPGMHEND 446

  Fly   359 QRVKISSADPKQ--QGILDLWKMKNMDNIVELHNKTPVWNDETQSYVLNFHGRVTQASVKNFQLV 421
            :||.|.   ||.  :.:|..::..|.:|:|.|.||:|.||::|||||||||||||||||||||:|
Zfish   447 ERVVIR---PKSELESLLTRYENGNKENLVTLVNKSPSWNEQTQSYVLNFHGRVTQASVKNFQIV 508

  Fly   422 HDSDPEYIVMQFGRTSEDVFTMDYRYPLCAMQAFAIALSSFDGKIACE 469
            |..:.:||||||||.::|||:|||.:|:||:|||||.|||||||:|||
Zfish   509 HPDNVDYIVMQFGRVADDVFSMDYSFPMCALQAFAITLSSFDGKLACE 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ktub	NP_611549.2	Tub	228..462	CDD:279506	143/242 (59%)
si:dkey-220f10.4	XP_003199647.1	Tub_N	13..>65	CDD:292938	11/51 (22%)
si:dkey-220f10.4	XP_003199647.1	Tub	309..549	CDD:279506	143/242 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	344	1.000	Domainoid score	I1027
eggNOG	1	0.900	-	-		E1_KOG2502
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1445357at2759
OrthoFinder	1	1.000	-	-		FOG0000431
OrthoInspector	1	1.000	-	-		otm24451
orthoMCL	1	0.900	-	-		OOG6_101683
Panther	1	1.100	-	-	O	PTHR16517
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X288
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.780