DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ktub and tub

DIOPT Version :9

Sequence 1:	NP_611549.2	Gene:	ktub / 37400	FlyBaseID:	FBgn0015721	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_031755877.1	Gene:	tub / 493219	XenbaseID:	XB-GENE-962281	Length:	511	Species:	Xenopus tropicalis

Alignment Length:	522	Identity:	225/522 - (43%)
Similarity:	297/522 - (56%)	Gaps:	92/522 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RNQKMEQQRQLMEAYIRQKRASPGMVQASDLQINRPMSGMR----------------SNSRELH- 54
            |.||:::||.|:|...::||..|.|||::   ::....|.|                |||..::
Frog    23 RQQKLDRQRALLEQKQKKKRQEPLMVQSN---VDSRARGRRMKQSEEQAPLVESYNSSNSSTIYH 84

  Fly    55 ---AYDGPMQFISSPQNP---DQILTNGSPG---------------GIN-PVAMNTSRNHSNNMR 97
               |.....|.::..|.|   ..|...||.|               ||: |.|.....:...:..
Frog    85 VQEAEQDDAQVVAETQAPRPNKNIKAAGSAGCPTGSARKEKKAKQKGIDGPAAFQDEASSPGSQV 149

  Fly    98 SLSTINQEGKWSYTPRKADLIEEISSHELEDEESSPVTVIEQHQQSASHSANSTQSQKPRARQHS 162
            .:.|:.|.|                 ||.|..|::     ...||........|..:|..:...:
Frog   150 QILTVGQSG-----------------HEEEATETA-----ASGQQQGKQDLRITMQKKGISSSMN 192

  Fly   163 FSDNLDEDDYTNRNVAGA-APVRPAGMASSPYKDATLDGSSNGTGNGTGGESEGDVIGNIDQFVM 226
            |.:..||:|..:.:.:.. :..||....|......|:...|     ....|...|| .::::|.|
Frog   193 FDEEEDEEDEDSSSSSQLNSSTRPGSATSKKSSKETVSAPS-----PPSNEPSIDV-EDLEEFSM 251

  Fly   227 QPAPQGVLYKCRITRDRKGMDRGLFPIYYLHLERDYGKKIFLLGGRKRKKSKTSNYIVSCDPTDL 291
            :||||||..|||||||:||||||::|.|||||||:.|||:|||.||||||||||||::|.|||||
Frog   252 RPAPQGVTIKCRITRDKKGMDRGMYPTYYLHLEREDGKKVFLLAGRKRKKSKTSNYLISIDPTDL 316

  Fly   292 SRNADGFCGKLRSNVFGTSFTVFDNG-NKESTESP------RLDLAVIIYDTNILGFKGPRNMTV 349
            ||..:.|.||||||:.||.|||:||| |...|.|.      |.:||.|.|:||:|||||||.|:|
Frog   317 SRGGESFIGKLRSNLMGTKFTVYDNGVNPGKTTSSLEASNLRQELAAICYETNVLGFKGPRKMSV 381

  Fly   350 ILPGMTEDDQRVK----------ISSADPKQ--QGILDLWKMKNMDNIVELHNKTPVWNDETQSY 402
            |:||:.  ::.:|          :||..|.|  :.:|..|:.||.::::|||||||||||:||||
Frog   382 IIPGLM--NRTIKAPAIFPFYLFLSSLFPWQEHETLLSRWQNKNTESVIELHNKTPVWNDDTQSY 444

  Fly   403 VLNFHGRVTQASVKNFQLVHDSDPEYIVMQFGRTSEDVFTMDYRYPLCAMQAFAIALSSFDGKIA 467
            |||||||||||||||||::||:||:||||||||.:||||||||.||:||:|||||||||||.|:|
Frog   445 VLNFHGRVTQASVKNFQIIHDNDPDYIVMQFGRVAEDVFTMDYNYPMCALQAFAIALSSFDSKLA 509

  Fly   468 CE 469
            ||
Frog   510 CE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ktub	NP_611549.2	Tub	228..462	CDD:279506	163/252 (65%)
tub	XP_031755877.1	Tub_N	29..234	CDD:406673	47/234 (20%)
tub	XP_031755877.1	Tub	252..506	CDD:395929	165/255 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	343	1.000	Domainoid score	I1059
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	380	1.000	Inparanoid score	I2015
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1445357at2759
OrthoFinder	1	1.000	-	-		FOG0000431
OrthoInspector	1	1.000	-	-		otm49046
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X288
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060