DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ktub and Tulp1

DIOPT Version :9

Sequence 1:	NP_611549.2	Gene:	ktub / 37400	FlyBaseID:	FBgn0015721	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_006256279.1	Gene:	Tulp1 / 309900	RGDID:	1311062	Length:	544	Species:	Rattus norvegicus

Alignment Length:	480	Identity:	195/480 - (40%)
Similarity:	264/480 - (55%)	Gaps:	101/480 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QKRASPGMVQASDLQINRPMSGMRSNSRELHAYDGPMQFISSPQNPDQILTN-----GSPGGINP 83
            :|....|..:.|.|.   |....:...|:..|. ||...:.||..|.:.|..     |....:..
  Rat   132 EKEKKEGKKEKSSLP---PKKAPKERERKTKAL-GPKGDVGSPDAPQKPLKTKKKEVGEGTKLRK 192

  Fly    84 V----AMNTSRNHSNNMRSLSTIN----------------QEGKWSYTPRKADLIEEISSHELED 128
            |    |..|.:|.|   .|.:|:.                ::|.....|.|....|:....|.|:
  Rat   193 VKKKGAGETDKNPS---ESPATVRKKIPASMFLVGEGGTAEKGVKKKGPPKGSEEEKKEEEEEEE 254

  Fly   129 EESSPVTVIEQHQQSASHSANSTQSQKPRARQHSFSDNLDEDDYTNRNVAGAAPVRPAGMASSPY 193
            |::|||            ..||.|..:.:.:                   |...|:.....|.|.
  Rat   255 EDASPV------------MRNSNQKGRAKGK-------------------GKKKVKEERAPSPPV 288

  Fly   194 KDATLDGSSNGTGNGTGGESEGDVIGNIDQFVMQPAPQGVLYKCRITRDRKGMDRGLFPIYYLHL 258
            :                       :|...:||:||||||...:||:|||:||||||::|.|:|||
  Rat   289 E-----------------------VGEPREFVLQPAPQGRAVRCRLTRDKKGMDRGMYPSYFLHL 330

  Fly   259 ERDYGKKIFLLGGRKRKKSKTSNYIVSCDPTDLSRNADGFCGKLRSNVFGTSFTVFDNGNKE--- 320
            :.:  ||:|||.|||||:|||:||::|.|||:|||..:.|.||||||:.|..|||||||...
  Rat   331 DTE--KKVFLLAGRKRKRSKTANYLISSDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRG 393

  Fly   321 ---STESPRLDLAVIIYDTNILGFKGPRNMTVILPGMTEDDQRVKI---SSADPKQQGILDLWKM 379
               ..||.|.:||.::|:||:|||:|||.||||:|||..|::||.|   :|:|    |:|..|:.
  Rat   394 GGGDVESLRQELAAVVYETNVLGFRGPRRMTVIIPGMNSDNERVPIRPRNSSD----GLLVRWQN 454

  Fly   380 KNMDNIVELHNKTPVWNDETQSYVLNFHGRVTQASVKNFQLVHDSDPEYIVMQFGRTSEDVFTMD 444
            |.:::::|||||.|:||:::.||.|||.||||||||||||:||..||:|||:||||.:||.||:|
  Rat   455 KTLESLIELHNKPPIWNEDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLD 519

  Fly   445 YRYPLCAMQAFAIALSSFDGKIACE 469
            |||||||:|||||||||||||:|||
  Rat   520 YRYPLCALQAFAIALSSFDGKLACE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ktub	NP_611549.2	Tub	228..462	CDD:279506	145/242 (60%)
Tulp1	XP_006256279.1	SWIRM-assoc_2	<18..86	CDD:293105
Tulp1	XP_006256279.1	Tub	300..537	CDD:279506	145/242 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	334	1.000	Domainoid score	I1090
eggNOG	1	0.900	-	-		E1_KOG2502
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	374	1.000	Inparanoid score	I2033
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1445357at2759
OrthoFinder	1	1.000	-	-		FOG0000431
OrthoInspector	1	1.000	-	-		otm45959
orthoMCL	1	0.900	-	-		OOG6_101683
Panther	1	1.100	-	-	O	PTHR16517
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X288
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.870