DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ktub and tulp3

DIOPT Version :9

Sequence 1:	NP_611549.2	Gene:	ktub / 37400	FlyBaseID:	FBgn0015721	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001116953.1	Gene:	tulp3 / 100144732	XenbaseID:	XB-GENE-979585	Length:	509	Species:	Xenopus tropicalis

Alignment Length:	511	Identity:	221/511 - (43%)
Similarity:	303/511 - (59%)	Gaps:	71/511 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RNQKMEQQRQLMEAYIRQKRASPGMVQAS-DLQINRPMSG--------MRSNSRE-------LHA 55
            |:.|:|.||.|:|...|:||....|||:: |.:..||.||        ::|..::       |:.
Frog    22 RHLKLENQRTLLEQKQRKKRQEILMVQSNRDTRQRRPKSGKCEEQAPLVQSQKQKSVNCNVILNG 86

  Fly    56 YDGPMQFISSP----QNPDQILTNGSPGGINPVAMNTSRNHSNNMRSLSTINQEGKWSYTPRKAD 116
            .|||..|:.|.    .:..|:||.|.........:.|.....|..|: |..|.|.:.  ||
Frog    87 IDGPAAFLDSGFHELDSKIQVLTVGESCTDTDFNVGTGWPSCNEGRA-SPCNSERRG--TP---- 144

  Fly   117 LIEEISSHELEDEESS-PVTVI-----EQHQQSASHSA------NSTQSQKPRARQHSFSDNL-- 167
                     :.|||:: |:..|     |:.||:::...      .|.:..:...::...||:|
Frog   145 ---------VSDEENTQPLNSIGRSNLEKTQQNSNRQEILRKPDVSKRDLQELLQERGISDSLNF 200

  Fly   168 -----DEDDYTNRNVAGAAPVRPAGMASSPYKDATLDGSSNGTGNGTGGESEGDV--IGNIDQFV 225
                 |:||..:.:.|..|..|||..:|.  |..|    ..||......:..||:  ||::.:|.
Frog   201 DEDISDDDDGDDDDEACNASTRPASASSK--KSLT----ETGTAEAVPPDPSGDIGEIGDLKEFA 259

  Fly   226 MQPAPQGVLYKCRITRDRKGMDRGLFPIYYLHLERDYGKKIFLLGGRKRKKSKTSNYIVSCDPTD 290
            ::|||:||:.|.||:||:|||||||:|.||:|||||..:|:|||.|||||:||||||::|.||||
Frog   260 LRPAPRGVVIKTRISRDKKGMDRGLYPTYYMHLERDNNRKVFLLAGRKRKRSKTSNYLISIDPTD 324

  Fly   291 LSRNADGFCGKLRSNVFGTSFTVFDNGNKE-------STESPRLDLAVIIYDTNILGFKGPRNMT 348
            |||....|.||||||:.||.||::|||...       |..:.|.::|.:.|:||:|||||||.||
Frog   325 LSREGGNFIGKLRSNLMGTKFTIYDNGESPAKVQGHMSNPTTRQEMAAVCYETNVLGFKGPRKMT 389

  Fly   349 VILPGMTEDDQRVKISSADPKQQGILDLWKMKNMDNIVELHNKTPVWNDETQSYVLNFHGRVTQA 413
            |::|||..:.:|:.....: ..:.:|..|..|..:||:|||||.|||||:|||||||||||||.|
Frog   390 VLIPGMNLNHERIPFQPQN-DSESLLSRWGNKCQENIIELHNKAPVWNDDTQSYVLNFHGRVTHA 453

  Fly   414 SVKNFQLVHDSDPEYIVMQFGRTSEDVFTMDYRYPLCAMQAFAIALSSFDGKIACE 469
            ||||||:|||:||:||||||||.:||.||:||.|||||:|||::||||||.|:|||
Frog   454 SVKNFQIVHDNDPDYIVMQFGRVAEDFFTLDYSYPLCALQAFSVALSSFDSKLACE 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ktub	NP_611549.2	Tub	228..462	CDD:279506	147/240 (61%)
tulp3	NP_001116953.1	Tub_N	28..245	CDD:292938	59/238 (25%)
tulp3	NP_001116953.1	Tub	262..502	CDD:279506	147/240 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	343	1.000	Domainoid score	I1059
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20711
Inparanoid	1	1.050	380	1.000	Inparanoid score	I2015
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1445357at2759
OrthoFinder	1	1.000	-	-		FOG0000431
OrthoInspector	1	1.000	-	-		otm49046
Panther	1	1.100	-	-	O	PTHR16517
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2866
SonicParanoid	1	1.000	-	-		X288
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190