DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34396 and KCNK5

DIOPT Version :9

Sequence 1:NP_611547.2 Gene:CG34396 / 37398 FlyBaseID:FBgn0085425 Length:975 Species:Drosophila melanogaster
Sequence 2:NP_003731.1 Gene:KCNK5 / 8645 HGNCID:6280 Length:499 Species:Homo sapiens


Alignment Length:472 Identity:101/472 - (21%)
Similarity:165/472 - (34%) Gaps:168/472 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   530 LICMAML--LGFGGLLFRYTE-----GAAENIYKCEVRKVKRDFIDRLWDVSHNMREEDWKSLAR 587
            |:..|::  |..|..:|...|     .|.:|.|..::..:|                 ::..|.:
Human     7 LLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLK-----------------EFPCLGQ 54

  Fly   588 QKLRSFEDELNNLAELGLRRYPGQ--KSWNFVNCFIFCWTVITTIGYGHITPKTGMGRSLTIVYA 650
            :.|....:.:::.|..|:.....|  .:||:.|..||..|||||||||::.|||..||...:.|.
Human    55 EGLDKILEVVSDAAGQGVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYG 119

  Fly   651 IIGIPMFLIVLADLGKLFTRCVKFLWVYVRRMYYTRSCRRIRKQQQIRSAMTGFNTMYDMAIRRP 715
            :.|:|:.|..::.|||.|....|.|     ..:.|:....:||.|                    
Human   120 LFGVPLCLTWISALGKFFGGRAKRL-----GQFLTKRGVSLRKAQ-------------------- 159

  Fly   716 SMFFSNSAPENDEESQADAEAARSVGTSHPETPTSPYPETFEVDDEFNLPVSVASLL--LITYIL 778
                                                            :..:|..::  ::.:::
Human   160 ------------------------------------------------ITCTVIFIVWGVLVHLV 176

  Fly   779 LGSFGFLMMEPSWTPLDAFYYVFISMSTIGFGDLV----PSNPFYVMVSM---IYLMFGLALTSM 836
            :..|.|::.| .|..::..||.||::|||||||.|    ||..::.:...   :::..|||..|:
Human   177 IPPFVFMVTE-GWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSL 240

  Fly   837 FIN--------------------------------VVQIK--------------------LSDHF 849
            |:|                                .:|:|                    .:|..
Human   241 FVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQVKGSTASKDVNIFSFLSKKEETYNDLI 305

  Fly   850 KMASAKVGATIGMNMTSE---LGDEGGSQVKTPSELASV---HGSRLDRIEEDGQEANGNGH-SP 907
            |....|...|.|...|..   ||.:||.....|..|..:   ..:|:..:||..|.....|| |.
Human   306 KQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLVPLVVYSKNRVPTLEEVSQTLRSKGHVSR 370

  Fly   908 VPPLTSILRAPRPLSPA 924
            .|...::.|||...|||
Human   371 SPDEEAVARAPEDSSPA 387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34396NP_611547.2 RILP-like 135..>217 CDD:304877
Ion_trans_2 <614..670 CDD:285168 27/55 (49%)
Ion_trans_2 771..847 CDD:285168 26/136 (19%)
KCNK5NP_003731.1 Ion_trans_2 <81..137 CDD:311712 26/55 (47%)
Ion_trans_2 171..243 CDD:311712 23/72 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 312..335 7/22 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 360..388 11/28 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..499
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1418
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000030
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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