DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34396 and KCNK16

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001128577.1	Gene:	KCNK16 / 83795	HGNCID:	14464	Length:	322	Species:	Homo sapiens

Alignment Length:	303	Identity:	66/303 - (21%)
Similarity:	109/303 - (35%)	Gaps:	110/303 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   527 IAYLICMAMLLGFGGLLFRYTEGAAENIYKCEVRKVKRDFIDRLWDVSHNMREEDWKSLARQKLR 591
            :|| :|..:|   |..:|:..|..||...:.:.:..|..|:            |::..|.:..:.
Human    19 LAY-VCYLLL---GATIFQLLERQAEAQSRDQFQLEKLRFL------------ENYTCLDQWAME 67

  Fly   592 SF-----EDELNNLAELGLRRYPGQKSWNFVNCFIFCWTVITTIGYGHITPKTGMGRSLTIVYAI 651
            .|     |..:..:...|....|  .:|:|.:.|.|..||:||||||::.|.|..|:...:.||:
Human    68 QFVQVIMEAWVKGVNPKGNSTNP--SNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYAL 130

  Fly   652 IGIPMFLIVLADLGKLFTRCVKFLWVYVRRMYYTRSCRRIRKQQQIRSAMTGFNTMYDMAIRRPS 716
            :|||:.:|.|..||                                    ||.....
Human   131 LGIPLNVIFLNHLG------------------------------------TGLRAHL-------- 151

  Fly   717 MFFSNSAPENDEESQADAEAARSVGTSHPETPTSPYPETFEVDDEFNLPVSVASLLLITYILLGS 781
                 :|.|..|:....::..:.:|                               |..::.||:
Human   152 -----AAIERWEDRPRRSQVLQVLG-------------------------------LALFLTLGT 180

  Fly   782 FGFLMMEP-------SWTPLDAFYYVFISMSTIGFGDLVPSNP 817
            ...|:..|       .|:..:.||:.||::|||||||.|..:|
Human   181 LVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGHP 223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	24/55 (44%)
		Ion_trans_2	771..847	CDD:285168	19/54 (35%)
KCNK16	NP_001128577.1	Ion_trans_2	<92..148	CDD:311712	26/91 (29%)
KCNK16	NP_001128577.1	Ion_trans_2	180..>224	CDD:311712	16/44 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810