DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34396 and CG42340

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001368973.1	Gene:	CG42340 / 7354472	FlyBaseID:	FBgn0259242	Length:	759	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	123/594 - (20%)
Similarity:	225/594 - (37%)	Gaps:	182/594 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   523 RNRCIA---YLICMAMLLGFGGLLFRYTEGAAEN------------------IYKCEVRKVKRDF 566
            ::.||:   .|:.:.:....|.::|...||..|:                  :...|:|.   ..
  Fly    90 KSHCISATGVLLLVLLYTAMGSIVFVTLEGELEDGGALETAVAASKPYPRTELANAEIRS---RT 151

  Fly   567 IDRLWDVSHNMR---EEDWKSLARQKLRSFEDELNNLAELGLRRYPG-------QKSWNFVNCFI 621
            :||||.::.::.   :|:|..||.|:::.|:|.|...........||       ...|.:.:.|:
  Fly   152 VDRLWSITEDLNILYKENWTRLAAQEVQLFQDTLLRAVRQSKVYPPGGIQLNAPTHKWTYASAFL 216

  Fly   622 FCWTVITTIGYGHITPKTGMGRSLTIVYAIIGIPMFLIVLADLGKLFTRCVKFLWVYVRRMYYTR 686
            :..|:|||||||.|:|:|..||...:|||:.|||:.|:.|:.:|:..:..::.|:   ||
  Fly   217 YSLTLITTIGYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEALSAGMRCLF---RR----- 273

  Fly   687 SCRRI--------------------------RKQQQIR-SAMTGFNTMYDMAIRRPSMFFSNSAP 724
              :|:                          ||..:.: ....|...::...: .||::....|.
  Fly   274 --QRVKGGPGGGPGGGASGGVGSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGL-PPSVYQQQQAQ 335

  Fly   725 ENDEESQADAEAARSV--------GTSHPETPTSPYPETFEVDDEFNLPVSVASLLLITYILLGS 781
            :..:..|..|:.|:..        ..|......||           ::|:|:...:|:.|:..|:
  Fly   336 QAQQAQQQQAQQAQQAQQQQVQQGKKSSGNRRGSP-----------SVPISICVCVLLCYVSSGA 389

  Fly   782 FGFLMMEPSWTPLDAFYYVFISMSTIGFGDLVPSNPFYVMVSMIYLMFGLALTSMFINVVQIKL- 845
            ..|..:: :|:.|::.|:.|.|:.|||||::.|:....:..:..|::.|:|:.:|..:::|.::
  Fly   390 ILFHKLQ-NWSVLESLYFCFTSLGTIGFGEMAPNGAVALYTASAYILVGMAVVAMCFSLIQTEIV 453

  Fly   846 --------SDHFKMASAKVGATIGMNMTSE-----------------LGDEGGS---------QV 876
                    .||. |..|:..|.:.:.:|.:                 :|..||:         |.
  Fly   454 LWLRRFSVQDHV-MPKAEELALVTVAVTPKPSXQRPSADPSLGVGLGVGLAGGALGQPQNNLGQH 517

  Fly   877 KT----PSELASVHGSRLDRIEEDGQEANGNG-----HSPVPPLTSI------------------ 914
            :|    |:...:.:.|...|........:|.|     ::|:...|.|
  Fly   518 QTMFFGPAHTLTQYSSLPRRSHLQAANNSGGGSAFQRNTPIRRSTGIPEHHLEYFVPRSISEFNL 582

  Fly   915 -------LRAPRPLSP--ASNGVDANGVGADAVGAG-------------DVTPPPLL-----PRR 952
                   |..||..||  ...|....|:|.:..|.|             .:.||..|     |..
  Fly   583 SGVGDLALPPPRRYSPNMVGGGGGMGGMGMNMGGMGMNMGMGMGLPHGLQLGPPQTLLCSAAPTV 647

  Fly   953 QVSVDPQPP 961
            |....|.||
  Fly   648 QQQQQPPPP 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	24/55 (44%)
		Ion_trans_2	771..847	CDD:285168	20/84 (24%)
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:400301	24/55 (44%)
CG42340	NP_001368973.1	Ion_trans_2	380..453	CDD:400301	20/73 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461313
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850