DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34396 and KCNK2

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001017425.2	Gene:	KCNK2 / 3776	HGNCID:	6277	Length:	426	Species:	Homo sapiens

Alignment Length:	408	Identity:	89/408 - (21%)
Similarity:	150/408 - (36%)	Gaps:	142/408 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   529 YLICMAMLLGFGGLLFRYTEGAAENIYKCEVRKVKRDFIDRLWDVSH---NMREEDWKSLARQKL 590
            :|:.:..|: .|..:|:..|...|...:..:...|:.||.:     |   |..|.|  .|.:|.:
Human    66 FLVVVLYLI-IGATVFKALEQPHEISQRTTIVIQKQTFISQ-----HSCVNSTELD--ELIQQIV 122

  Fly   591 RSFEDELNNLAELGLRRYPGQKS-WNFVNCFIFCWTVITTIGYGHITPKTGMGRSLTIVYAIIGI 654
            .:.     |...:.|.....|.| |:..:.|.|..|||||||:|:|:|:|..|:...|:||::||
Human   123 AAI-----NAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGI 182

  Fly   655 PMFLIVLADLGKLFTRCVKFLWVYVRRMYYTRSCRRIRKQQQIRSAMTGFNTMYDMAIRRPSMFF 719
            |:|..:||.:|                             .|:       .|::...|.:
Human   183 PLFGFLLAGVG-----------------------------DQL-------GTIFGKGIAK----- 206

  Fly   720 SNSAPENDEESQADAEAARSVGTSHPETPTSPYPETFEVDDEF-NLPVSVASLLLITYILLGSFG 783
                                                  |:|.| ...||...:.:|:.|:...||
Human   207 --------------------------------------VEDTFIKWNVSQTKIRIISTIIFILFG 233

  Fly   784 FLMME----------PSWTPLDAFYYVFISMSTIGFGDLVPSN------PFYVMVSMIYLMFGLA 832
            .::..          ..|:.|||.|:|.|:::||||||.|...      .||..|...:::.|||
Human   234 CVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLA 298

  Fly   833 LTSMFINVVQIKLSDHFKMASAKVGATIG----------MNMTSELGD-------------EGGS 874
            ..:..::::    .|..::.|.|....:|          .|:|:|..:             :..:
Human   299 YFAAVLSMI----GDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRAT 359

  Fly   875 QV--KTPSELASVHGSRL 890
            .:  |..:|||..|...|
Human   360 SIKRKLSAELAGNHNQEL 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	25/55 (45%)
		Ion_trans_2	771..847	CDD:285168	24/91 (26%)
KCNK2	NP_001017425.2	Ion_trans_2	<142..196	CDD:400301	25/82 (30%)
		Ion_trans_2	234..312	CDD:400301	21/81 (26%)
		Required for basal channel activity. /evidence=ECO:0000250	354..426		6/24 (25%)
		Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250	378..426		89/408 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810