DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34396 and KCNK1

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_002236.1	Gene:	KCNK1 / 3775	HGNCID:	6272	Length:	336	Species:	Homo sapiens

Alignment Length:	323	Identity:	79/323 - (24%)
Similarity:	129/323 - (39%)	Gaps:	104/323 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   526 CIAYLICMAML-LGFGGLLFRYTEGAAENIYKCEVRKVKRDFIDRLWDVSHNMREEDWKSLARQK 589
            |..:|:...:| |.||.::|...|...|::.:.|:||:||.|:            |:.:.|:.|:
Human    22 CFGFLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFL------------EEHECLSEQQ 74

  Fly   590 LRSFED---ELNNLAELGLRRYPGQKSWNFVNCFIFCWTVITTIGYGHITPKTGMGRSLTIVYAI 651
            |..|..   |.:|.....|....|..:|:|.:...|..||::|.||||..|.:..|::..|:|::
Human    75 LEQFLGRVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSV 139

  Fly   652 IGIPMFLIVLADLGKLFTRCVKFLWVYVRRMYYTRSCRRIRKQQQIRSAMTGFNTMYDMAIRRPS 716
            ||||..|:.|       |..|:.:.|:|                                .|||.
Human   140 IGIPFTLLFL-------TAVVQRITVHV--------------------------------TRRPV 165

  Fly   717 MFFSNSAPENDEESQADAEAARSVGTSHPETPTSPYPETFEVDDEFNLPVSVASLLLITYILLGS 781
            ::|                        |.....|            ...|::...:|:.::.:..
Human   166 LYF------------------------HIRWGFS------------KQVVAIVHAVLLGFVTVSC 194

  Fly   782 FGFL------MMEPSWTPLDAFYYVFISMSTIGFGDLVPSNPF-------YVMVSMIYLMFGL 831
            |.|:      ::|..|..|::||:.|||:||||.||.||...:       |.:....||:.||
Human   195 FFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGL 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	20/55 (36%)
		Ion_trans_2	771..847	CDD:285168	24/74 (32%)
KCNK1	NP_002236.1	Ion_trans_2	<101..157	CDD:400301	22/62 (35%)
		pore-forming domain	107..123		7/15 (47%)
		Ion_trans_2	192..267	CDD:400301	23/66 (35%)
		pore-forming domain	212..238		14/25 (56%)
		Important for intracellular retention in recycling endosomes. /evidence=ECO:0000269\|PubMed:19959478	293..299
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810