DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34396 and twk-48

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001022681.1	Gene:	twk-48 / 3565640	WormBaseID:	WBGene00010784	Length:	372	Species:	Caenorhabditis elegans

Alignment Length:	377	Identity:	104/377 - (27%)
Similarity:	183/377 - (48%)	Gaps:	61/377 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   515 KVKELRQLRNRCIAYL-----ICMAMLLGF---GGLLFRYTEGAAENIYKCEVRKVKRDFIDRLW 571
            ||..:..|..:.||:.     :| |:::|:   |.::|:..||..|...:..|:..:...:|.:|
Worm     9 KVTRVVNLVKKIIAFFFSHIGLC-ALVVGYALLGAVIFKAVEGPHEAEIQELVKSAREKAVDVVW 72

  Fly   572 DVSHNMREED---WKSLARQKLRSFEDELNNLAELGLRR------YPGQKSWNFVNCFIFCWTVI 627
            :.:..:...|   ||.....:::.|:    .:..|.:|:      |..|..|.|...|::..|||
Worm    73 NATFRVNRLDSKQWKKTVLDEVKRFK----TVCMLSIRKGYDGKEYGKQAQWTFTGAFLYSLTVI 133

  Fly   628 TTIGYGHITPKTGMGRSLTIVYAIIGIPMFLIVLADLGKLFTRCVKFLWVYVRRMYY-------T 685
            ||||||:...||.:|::||::|||||||:.|:.|.::|.:..:..:||:....|:.:       .
Worm   134 TTIGYGNTAAKTYIGKTLTMLYAIIGIPLMLLFLTNIGDVMAKIFRFLYAQSIRLKFRLILWHKK 198

  Fly   686 RSCRRIRKQQQIRSAMT-GFNTMYDMAIRRPSMFFSNSAPENDEESQADAEAARSVGTSHPETPT 749
            |...:||:...:.|.:| |.....|.::..    |...|       .||.|   .:.|:..|...
Worm   199 RKAAKIRRANSLVSRLTRGHRVKADSSVDS----FGLGA-------GADVE---DLLTARVEMEQ 249

  Fly   750 SPYPETFEVD-DEFNLPVSVASLLLITYILLGSFGFLMMEPSWTPLDAFYYVFISMSTIGFGDLV 813
            ....||.... :...:|:|:....::.|:.:|:..|.:.| .||.|::||:.|||::||||||..
Worm   250 LEVRETAAAQLESMTVPISLVVFTMLGYLGVGTTIFKVWE-GWTFLESFYFCFISLTTIGFGDKF 313

  Fly   814 PSNPF--------YVMVSMIYLMFGLALTSMFINVVQIK-------LSDHFK 850
            ||...        .::::.|||:||:||.:|..|:.|.:       ::|.|:
Worm   314 PSTSVSNTDEAQEKLVITSIYLLFGMALLAMCFNLAQEEVQNKTRWIADKFR 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	27/55 (49%)
		Ion_trans_2	771..847	CDD:285168	30/90 (33%)
twk-48	NP_001022681.1	Ion_trans_2	<117..176	CDD:285168	28/58 (48%)
twk-48	NP_001022681.1	Ion_trans_2	272..355	CDD:285168	30/83 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5602
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8678
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.800