DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34396 and Kcnk18

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_997144.1	Gene:	Kcnk18 / 332396	MGIID:	2685627	Length:	394	Species:	Mus musculus

Alignment Length:	384	Identity:	96/384 - (25%)
Similarity:	162/384 - (42%)	Gaps:	99/384 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   527 IAYLICMAMLLGFGGLLFRYTEG-----AAENIYKCEVRKVKRDFIDRLWDVSHNMREEDWKSLA 586
            :.:|.|:......|..||...||     |.||   .|::|    |:|            |..::.
Mouse    35 LCFLCCLVTYALVGAALFSAVEGRPDPEAEEN---PELKK----FLD------------DLCNIL 80

  Fly   587 RQKLRSFEDELNNLAE----LGLRRYPGQKSWNFVNCFIFCWTVITTIGYGHITPKTGMGRSLTI 647
            :..|...|....||.|    |..:.....:.|:|::...||.||.:|:||||:.|.|.:|:.|.:
Mouse    81 KCNLTVVEGSRKNLCEHLQHLKPQWLKAPQDWSFLSALFFCCTVFSTVGYGHMYPVTRLGKFLCM 145

  Fly   648 VYAIIGIPMFLIVLADLG--------KLFTR-----CVK---FLWVYVRRMYYTRS---CRRIRK 693
            :||:.|||:..:||.|:|        :.::|     |:.   |.|         ||   ||:...
Mouse   146 LYALFGIPLMFLVLTDIGDILATILSRAYSRFQALLCLPHDIFKW---------RSLPLCRKQPD 201

  Fly   694 QQQIRSAMTGFNTMYDMAIRRPSMFFSNSAPENDEESQA------DAEAARSVGTSHPETPTSPY 752
            .:.:..|:.  ..:.|..:..    ..|..|..|..|.:      :...||. ..:..:.||.|.
Mouse   202 SKPVEEAIP--QIVIDAGVDE----LLNPQPSKDPPSPSCNVELFERLVARE-KKNKLQPPTRPV 259

  Fly   753 ------PETF-------------EVD---DEFNLPVSVASLLLITYILLGSFGFLMMEPSW-TPL 794
                  ||..             ||.   :..::|:.|.:|::..||...:    .:.|.| |.|
Mouse   260 ERSNSCPELVLGRLSCSILSNLDEVGQQVERLDIPLPVIALVVFAYISCAA----AILPFWETEL 320

  Fly   795 ---DAFYYVFISMSTIGFGDLVPSNPFYVMVSMIYLMFGLALTSMFINVVQIKLSDHFK 850
               ||||:.|::::||||||:|..:|.:.:...||::.|:.:..:...::|.:|...:|
Mouse   321 GFEDAFYFCFVTLTTIGFGDIVLVHPHFFLFFSIYIIVGMEILFIAFKLMQNRLLHTYK 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	24/63 (38%)
		Ion_trans_2	771..847	CDD:285168	25/79 (32%)
Kcnk18	NP_997144.1	Ion_trans_2	<111..166	CDD:285168	24/54 (44%)
		Interaction with calcineurin	210..215		0/6 (0%)
		Interaction with YWHAH. /evidence=ECO:0000269\|PubMed:18397886	261..266		0/4 (0%)
		Ion_trans_2	300..376	CDD:285168	25/79 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845637
Domainoid	1	1.000	65	1.000	Domainoid score	I10032
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5602
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8678
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720