DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34396 and twk-21

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_510654.2	Gene:	twk-21 / 192078	WormBaseID:	WBGene00006674	Length:	581	Species:	Caenorhabditis elegans

Alignment Length:	723	Identity:	151/723 - (20%)
Similarity:	248/723 - (34%)	Gaps:	287/723 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 ESRDEVIKPRISEAEQQS----ELMQKYMEAAERAAK---AEA----ALAEQILTAEGVRRSHSL 381
            :.:|.:.:.|.:..|:|:    :::.||:....:..|   |||    |..||:.|.:....|..|
Worm     2 QQKDSIRRQRSNLNEEQTNEARKILSKYVRQRRKYGKNNVAEANKENANIEQLHTPDTESESQFL 66

  Fly   382 RLADKEEKPQKRSSSLERPLRPKRSGSLERKEQVTQELLEGTTTNEADTEPKSLGDQPLLPEESI 446
            |       |.||.|:                                     |....|..|::..
Worm    67 R-------PVKRRSN-------------------------------------SFNSTPSTPDDYE 87

  Fly   447 SEAKPKVTLWQRLKNLFRRKKKIQAKGEDVTDLSTELPLEKLASRGLLYSFSLEARHEWKRLKLD 511
            |...|:.:                   :|..:::.:..|.:.         |.|...:|
Worm    88 SFFSPEFS-------------------QDPEEINIKKDLRQR---------SQETWGQW------ 118

  Fly   512 YPQKVKELRQLRNRCIAYLICMAMLLGF---GGLLF------------------RYTEGA----- 550
            :.:.|:.|.:|..  |.|::.:.::||:   ||.:|                  |.:|.:
Worm   119 FVRVVETLSELLG--IRYIMLILIILGYACLGGYMFQALEYDQQQLELEAEKRVRLSESSLLAVN 181

  Fly   551 -----------AENIYKCEVRKVKRDFIDRLWDVSHNMREEDWKSLARQKLRSFEDELNNLAELG 604
                       ..|..:| :..:.:.||.|    |...|.|.|:
Worm   182 LLEHLKQMNCGQSNEKRC-LELITKTFIQR----SDEERGEGWR--------------------- 220

  Fly   605 LRRYPGQKSWNFVNCFIFCWTVITTIGYGHITPKTGMGRSLTIVYAIIGIPMFLIVLADLGKLFT 669
                     |:|.|...|..|:.||||||::..||.:||..||:|.:||||:.|.||.:.|:|
Worm   221 ---------WDFWNSVFFSATIFTTIGYGNLACKTNLGRIATIIYGMIGIPLMLFVLKNFGEL-- 274

  Fly   670 RCVKFLWVYVRRMYYTRSCRRIRKQQQIRSAMTGFNTMYDMAIRRPSMFFSNSAPENDEESQADA 734
             |||  |....:....:..::...::|.|::.....|..:|.    .:||  ..||:|:|
Worm   275 -CVK--WAKKIQFNVQQCLKKCFGRKQKRASSLASITSKEML----EVFF--EVPEDDKE----- 325

  Fly   735 EAARSVGTSHPETPTSPYPETFEVDDEFNLPVSVASLLLITYILLGSFGFLMMEPSWTPLDAFYY 799
                                    |..|.|...:  |:::.:::|.||.....| :|..|.|||:
Worm   326 ------------------------DTTFQLRWGL--LVIVLFVVLCSFVVSFWE-NWDFLTAFYF 363

  Fly   800 VFISMSTIGFGDLVPSNPFYVMVSMIYLMFGLALTSMFINVVQ----------IKLSD------- 847
            .|:|:|||||||:||.:|.......:....||||.:|...::|          ::|.|
Worm   364 FFVSLSTIGFGDIVPDHPRTACALFVLYFIGLALFAMVYAILQERVENQYMWALELIDQKYQEKL 428

  Fly   848 -----------------HF----------------------KMASAKVGATIGMNMTSELGDEGG 873
                             ||                      |::..:..::...::.:|..||..
Worm   429 KQDMYDEDEKKADKNDMHFSKKEPVRGPRILLQDLLRGPDLKISGGRRSSSDASSVITEASDEDT 493

  Fly   874 SQVK----------TPSELASVHGSRLDRIEEDGQEANGNGHSPVP-----PLTSI--------- 914
            ...|          .|.|.||.|||. :.:||...|......:|.|     |.|:.
Worm   494 RHFKVGRAILAEAFAPDERASNHGSD-ESLEEHQLETYDTSGTPPPYGDPTPTTNFQTRDETVTS 557

  Fly   915 LRAPRPLS 922
            |....|||
Worm   558 LAEKTPLS 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	27/55 (49%)
		Ion_trans_2	771..847	CDD:285168	29/85 (34%)
twk-21	NP_510654.2	Ion_trans_2	<219..277	CDD:285168	29/90 (32%)
twk-21	NP_510654.2	Ion_trans_2	345..411	CDD:285168	26/66 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163826
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.710