DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34396 and twk-2

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001350984.1	Gene:	twk-2 / 188452	WormBaseID:	WBGene00006657	Length:	1519	Species:	Caenorhabditis elegans

Alignment Length:	374	Identity:	94/374 - (25%)
Similarity:	164/374 - (43%)	Gaps:	84/374 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   514 QKVKELRQLRNRCIAYLICMAMLLGFGGLLFRYTEGAAENIYKCEVRKVKRDFIDRLWDVSHNMR 578
            |.:::..:|....|..::|:.:....|..:|...|...|:..|...||...:....|....:|..
Worm    25 QNIRKYAKLALPHIVLVVCVCIYATIGAWIFYTLESPNEDRLKETGRKTIAEMRSNLIYKINNNE 89

  Fly   579 EEDWKSLARQKLRSFEDEL-----------NNLAELGL-------------------RRY----- 608
            :|.||....::|..:.::|           :::..:|.                   ||:
Worm    90 KEVWKEDIEKELMLYSEKLYKAFKEQYVRYSDVRTIGFEGRSSYEEADETGGDSERKRRHRHGNK 154

  Fly   609 ----PGQKSWNFVNCFIFCWTVITTIGYGHITPKTGMGRSLTIVYAIIGIPMFLIVLADLGKLFT 669
                ..:|.|...:...|..|.:.|||||:|.|.|.:||...:::|:.|.|:.:|.:.||||..:
Worm   155 RGDRGSEKMWTTSSALFFAATTMATIGYGNIVPVTPLGRLACVLFALFGAPIAIITIGDLGKFLS 219

  Fly   670 RCVKFLWVYVRRMYYTRSCRRIRK-QQQIRSAMTGFNTMYDMAIRRPSMFFSN---SAPENDEES 730
            .|.  :|:|          :.:|| ..::.||...|..:.|.        .|:   ||.:|.:.|
Worm   220 ECT--IWLY----------KHMRKGSARLDSAWKRFRGLEDS--------ISDDLESASKNQDSS 264

  Fly   731 QADAEAARSVGTSHPETPTSPYPETFEVDDEFNLPVSVASLLLITYILLGSFGFLMMEPSWTPLD 795
            ..|.:                    .:..|:..:||.:...:::.||..|...|.::| .|:.:|
Worm   265 ILDMD--------------------MDEIDKSEVPVLMVFTIILLYIAFGGILFSILE-DWSYMD 308

  Fly   796 AFYYVFISMSTIGFGDLVPSNPFYVMVSMIYLMFGLALTSMFINVVQIK 844
            ||||.|||::||||||:||.|..|:.:.:|||..||::|:|.|::..|:
Worm   309 AFYYSFISLTTIGFGDIVPENHDYIAIMLIYLGVGLSVTTMCIDLAGIQ 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	21/55 (38%)
		Ion_trans_2	771..847	CDD:285168	33/74 (45%)
twk-2	NP_001350984.1	Ion_trans_2	<164..220	CDD:311712	21/55 (38%)
twk-2	NP_001350984.1	Ion_trans_2	285..360	CDD:311712	33/74 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I6066
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820