DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34396 and twk-28

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_508732.3	Gene:	twk-28 / 183714	WormBaseID:	WBGene00006680	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	518	Identity:	129/518 - (24%)
Similarity:	213/518 - (41%)	Gaps:	135/518 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 TQELLEGTTTNEADTEPKSLGDQPLLPEESISEAKPKVTLWQRLKNLFRRKKKIQAKGEDVTDLS 480
            |...::......||:...||.:.|:  |..::.|.|.::                   :|.|::.
Worm     3 THNAVDTFDMGSADSSLSSLNEIPM--EMDLTSAGPPIS-------------------DDETEVE 46

  Fly   481 TELPLEKLASRGLLYSFSLEARHEWKRLKLDYPQKVKELRQLRNRCIAY---LICMAMLLGFGGL 542
            |                                 |.|:|.....|.:.:   :|.:.:.|..|..
Worm    47 T---------------------------------KEKKLFVYAKRILPHVGLVILLFLYLIAGAF 78

  Fly   543 LFRYTEGAAE----NIYKCEVRKVKRDFIDRLWDVSHN------------MREEDWKSLARQKLR 591
            ||||.|...|    |.....:..::.:|.|.:|:::.:            :.:|.::.|.:...:
Worm    79 LFRYLEAPKELETRNHELTTILGLRDEFQDHIWNITQDSDNRISREAFNAINQEYFEQLVKNMFQ 143

  Fly   592 SFEDELNNLAELGLRRYPGQKSWNFVNCFIFCWTVITTIGYGHITPKTGMGRSLTIVYAIIGIPM 656
            ::.::......|..:....:..|.|.|...|..|||||||||::.|.|..||...|::|::|||:
Worm   144 AYRNQFITAKHLLNKTREDEVLWTFPNSMFFAATVITTIGYGNLVPITVTGRVACIIFALLGIPL 208

  Fly   657 FLIVLADLGKLFTRCVKFLWVYVRRMY--YTRSCRR--------IRKQQQIRSAMTGFNTMYDMA 711
            .|:.:||:||..:..:.:|:    |.|  :.|..||        .|.|.|.||:..
Worm   209 LLVTIADIGKFLSEFLSYLY----RSYRGFKRKLRRQSKKITSQYRSQSQSRSSSV--------- 260

  Fly   712 IRRPSMFFSNSAPENDEESQADAEAARSVGTSHPETPTSPYPETFEVDDEFNLPVSVASLLLITY 776
                 |..|.:...|..:..:|:|  .|.|                  ||..:||.:..|:|:.|
Worm   261 -----MGSSKAGSMNLHDIDSDSE--DSAG------------------DELRIPVFMVLLVLLAY 300

  Fly   777 ILLGSFGFLMMEPSWTPL---DAFYYVFISMSTIGFGDLVPSNPFYVMVSMIYLMFGLALTSMFI 838
            ..:|.|.|    .||..|   :|||:.||:|:|:||||:||:...||..:|.|::|||:|.:|.|
Worm   301 TAIGGFLF----QSWEHLEYFEAFYFCFITMATVGFGDIVPNEQVYVFFTMAYIIFGLSLATMCI 361

  Fly   839 NVVQIKL--SDHF---KMASAKVGATIGMNMTSELGDEGGSQV-KTP-SELASVHGSRLDRIE 894
            ::...:.  ..|:   ||..||.....|:.....|....|.:| ||. .:|..|.|:.|...|
Worm   362 DLAGTEYIRKIHYLGTKMEDAKGAVMTGLQAGEHLLKHTGIEVIKTAGGKLVQVRGAVLSSKE 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	27/55 (49%)
		Ion_trans_2	771..847	CDD:285168	32/80 (40%)
twk-28	NP_508732.3	Ion_trans_2	<166..222	CDD:285168	27/55 (49%)
twk-28	NP_508732.3	Ion_trans_2	295..370	CDD:285168	32/78 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I6066
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8678
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850