DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34396 and twk-22

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001361830.1	Gene:	twk-22 / 181703	WormBaseID:	WBGene00006675	Length:	749	Species:	Caenorhabditis elegans

Alignment Length:	710	Identity:	146/710 - (20%)
Similarity:	235/710 - (33%)	Gaps:	237/710 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 ERLSVSRNNSLSPVRPQRRSKTPEQREEILRKHEYLEVGESRDEVIKPRISEAEQQSELMQKYME 353
            |:|::.........|.|||:  |.:|:..|            |:      .:..|..:|::||:.
Worm    31 EQLTLRNQEYSDDNRMQRRA--PIRRKSAL------------DD------DQTSQAMKLLEKYIR 75

  Fly   354 AAERAA---KAEAALAEQILTAEGVRRSHSLRLADKEEKPQKRSSSLERPLRPKRSGSLERKEQV 415
            ...|.:   ..::|..||..|..|  .:.|.....:...|::|:.....||.|..|
Worm    76 KKYRHSVIFSQDSADIEQSSTPVG--HTQSACQFSRNLTPEQRNGFYSTPLGPAPS--------- 129

  Fly   416 TQELLEGTTTNEADTEPKSLGDQPLLPEESISEAKPKVTLWQRLKNLFRRKKKIQAKGEDVTDLS 480
                       |....|.|    |...|.:|.|
Worm   130 -----------EYHFPPGS----PQFRESTIRE-------------------------------- 147

  Fly   481 TELPLEKLASRGLLYSFSLEARHEWKRLKLDYPQKVKELRQLRNRCIAYLICMAMLLGF---GGL 542
                           .|..:.|..|...   :.:..|.|.:|..  |.|::...|:||:   ||.
Worm   148 ---------------EFKQQYRETWGHW---FVRVGKFLYKLLG--IQYMLLALMILGYACLGGY 192

  Fly   543 LF------------------RYTEGA--AENIYK--------------CEVRKVKRDFIDRLWDV 573
            :|                  |.:|..  |||:.|              | :..:.:.||:|...|
Worm   193 IFLTLEYDQQQLDLEVEKQVRLSESTLLAENLLKYLKQWNCGQSNENRC-LELITKAFIERSIKV 256

  Fly   574 SHNMREEDWKSLARQKLRSFEDELNNLAELGLRRYPGQKSWNFVNCFIFCWTVITTIGYGHITPK 638
            ..::|.|.|:                              |:|.|...|..|:.||||||::..|
Worm   257 ERDIRGEGWR------------------------------WDFWNSVFFSATIFTTIGYGNLACK 291

  Fly   639 TGMGRSLTIVYAIIGIPMFLIVLADLGKLFTRCVKFLWVYVRRMYYTRSCRRIRKQQQIRSAMTG 703
            |.:||..||:|.:||||:.|.||...|:   ..:|  |....|....|..:|..::.:::.|.|
Worm   292 TNLGRVATIIYGLIGIPLMLFVLKIFGE---HSIK--WAQKVRYSIRRCVKRCFRRSKLKRAST- 350

  Fly   704 FNTMYDMAIRRPSMFFSNSAPENDEESQADAEAARSVGTSHPETPTSPYPETFEVDDEFNLPVSV 768
                                   .|...:|.......|.|..|...:.:|..:        .:.:
Worm   351 -----------------------IESVASDEMPCEESGISEDEEQITTFPVKW--------ALFI 384

  Fly   769 ASLLLITYILLGSFGFLMMEPSWTPLDAFYYVFISMSTIGFGDLVPSNPFYVMVSMIYLMFGLAL 833
            ....::...|:.||.     ..|..|.|||:.|:|:|||||||::|.:|.......:....||||
Worm   385 VFFFMVVCSLIVSFW-----EKWDFLTAFYFFFVSLSTIGFGDVIPEHPRTACALFVLYFVGLAL 444

  Fly   834 TSMFINVVQIKLSDHFKMASAKVGATIGMNMTSELGDEGGSQVKTPSELASVHG--SRLDRIEED 896
            .||...::|.::.:.:..|...:......|...:..|........|...|.:.|  :.:.::...
Worm   445 FSMVYAILQERVENQYMWALELIDQEYQENQKQDPDDHLEIPTILPENAAGMEGWTNTIGKMVSQ 509

  Fly   897 GQ---EANGNGHS----PVPPLTSILRAPRPLSPASNGVDANGVGADAVGAGDVTPPPLL 949
            ..   .|..:.:|    |..|::.  |....|||               |.....|||:|
Worm   510 NPVRWRAKNSAYSMENMPDRPISE--RRFSVLSP---------------GEAPQAPPPVL 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	26/55 (47%)
		Ion_trans_2	771..847	CDD:285168	26/75 (35%)
twk-22	NP_001361830.1	Ion_trans_2	259..319	CDD:369572	28/89 (31%)
twk-22	NP_001361830.1	Ion_trans_2	381..457	CDD:369572	26/80 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163825
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850