DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34396 and twk-46

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_741678.1	Gene:	twk-46 / 180252	WormBaseID:	WBGene00006696	Length:	319	Species:	Caenorhabditis elegans

Alignment Length:	376	Identity:	87/376 - (23%)
Similarity:	147/376 - (39%)	Gaps:	114/376 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   519 LRQLRNRCIAYLICMAMLLGFGGLLFRYTEGAAENIYKCEVRKVKRD-FIDRLWDVSHNMREEDW 582
            :|:...|.:..|....:.|..|.::|...|      |..|  |::|: ::|         .:..|
Worm    20 MRESNMRILVGLGVAVVYLFVGAIVFVRIE------YPLE--KIEREAYLD---------YQNQW 67

  Fly   583 KSLARQKLRSFEDELN----NLAELGL------RRYPGQKSWNFVNCFIFCWTVITTIGYGHITP 637
            :....| |...|.|::    |:.|..|      |......:|.|...|.|..|:|:|:|||.::|
Worm    68 RDRLIQ-LDIDESEIDKLFLNIREAALNGIWMDRNLTSDPNWTFGQAFFFAGTLISTVGYGRVSP 131

  Fly   638 KTGMGRSLTIVYAIIGIPMFLIVLADLGKLFTRCVKFLWVYVRRMYYTRSCRRIRKQQQIRSAMT 702
            :|..|:..||:|.:||||:.|.:|:.:              |.||.        ....::|..:.
Worm   132 RTEYGKLFTILYCVIGIPLTLALLSAI--------------VARMR--------EPSHKLRGLLN 174

  Fly   703 GFNTMYDMAIRRPSMFFSNSAPENDEESQADAEAARSVGTSHPETPTSPYPETFEVDDEFNLPVS 767
                      :|....|:                     .:|.:.              .::.|.
Worm   175 ----------QRLGHLFT---------------------VNHIQL--------------IHVGVV 194

  Fly   768 VASLLLITYILLGSFGFLMMEPSWTPLDAFYYVFISMSTIGFGDLVPSNP-------FYVMVSMI 825
            .|||||..: .:.::.|..:|..|:.||||||.|:|::|||.||..|.:.       .|.:.:.:
Worm   195 FASLLLFVF-AIPAWVFSSIETDWSYLDAFYYCFVSLTTIGLGDFEPGDDPNQSFRGLYKIGATV 258

  Fly   826 YLMFGLALTSMFI----NVVQIKLSDHFKMASAKVGATIGMNMTSELGDEG 872
            |||.||....:|:    ::.|..|:..|..:..:      |..:.|.|..|
Worm   259 YLMGGLCCMMLFLATLYDIPQFNLTSFFVKSDEE------MRFSEEDGKYG 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	22/55 (40%)
		Ion_trans_2	771..847	CDD:285168	29/86 (34%)
twk-46	NP_741678.1	Ion_trans_2	<107..164	CDD:285168	25/78 (32%)
twk-46	NP_741678.1	Ion_trans_2	198..274	CDD:285168	27/76 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163830
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840