DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34396 and twk-36

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_507485.2	Gene:	twk-36 / 180164	WormBaseID:	WBGene00006688	Length:	562	Species:	Caenorhabditis elegans

Alignment Length:	663	Identity:	152/663 - (22%)
Similarity:	248/663 - (37%)	Gaps:	190/663 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 QSELMQKYMEAAERAAKAEAALA----------EQILTAEGVRRSHSLRLADKEEKPQKRSSSLE 398
            :|.|.|||  ..||....:..|.          ..:||..|.|.:.|..|      |.:||:|::
Worm    11 KSILSQKY--TVERKDTVQHVLEGPGLSRNQSNASVLTLPGSRNTSSNHL------PAQRSTSVD 67

  Fly   399 RPLRPK--------RSGSLERKEQVTQELLEG--TTTNEADTEPKSLGDQPLLPEESISEAKPKV 453
            ...|.:        :|...|.:..::|...:.  |.|...:|..|       || .:||..:.:|
Worm    68 EVARHRVTYEMDAGKSEKSENQNPISQYYQKNHYTVTGNQETYQK-------LP-RNISANRFQV 124

  Fly   454 TLWQRLKNLFRRKKKIQAKGEDVTDLSTELPL---EKLASRGLLYSFSLEARHEWKRLKLDYPQK 515
            .           |..|..|.........|:|:   |:...:    ||...|.|. |:..|.|
Worm   125 D-----------KASISQKSAPRASEPMEMPMLPQERQFDK----SFYWFAMHR-KKFGLRY--- 170

  Fly   516 VKELRQLRNRCIAYLICMAMLLGFGGLLFRYTEGAAENIYKCEVRKVKRD-FIDRLWDVSHNMRE 579
                       ||.|:...:....|..:|...||:.|. .:..||:...| .:|.|..|......
Worm   171 -----------IALLVLALIYTLLGATVFYLIEGSNEK-SRLHVREQNLDKLLDELATVLSEAVN 223

  Fly   580 EDWKSLARQKLRSFEDELNNLAELGLRR--------------YPGQKSWNFVNCFIFCWTVITTI 630
            :..:|...|:::.|..|    :.:.|::              :|....|.|.:.|.|...|.||.
Worm   224 DPEQSSEHQRMKEFIKE----SYISLQKHEEQYKWSTYYRLEHPDNLKWTFSSAFFFSMNVYTTT 284

  Fly   631 GYGHITPKTGMGRSLTIVYAIIGIPMFLIVLADLGKLFTRCVKFLWVYVRRMYYTRSCRRIRKQQ 695
            |||.|:.:|..|:..|::||...:|:.|::|.|||::|  .|.|..:|...:   .:.||||.::
Worm   285 GYGSISAQTFSGQLFTMIYAFCFVPVTLVILRDLGQMF--LVNFTKLYAHGL---TAVRRIRGKR 344

  Fly   696 QIRSAMTGFNTMYDMAIRRPSMFFSNSAPENDEESQADAEAARSVGTSHPETPTSPYPETFEVDD 760
            ::                             ||                              |:
Worm   345 EV-----------------------------DE------------------------------DE 350

  Fly   761 EFNLPVSVASLLLITYILL-GSFGFL---MMEPSWTP----LDAFYYVFISMSTIGFGDLVPSN- 816
            ...||:.....:||.|:|| .:|.:|   :|.|.|..    ..|||:.|||::|||.||::|:|
Worm   351 IIQLPIKFCMTILIAYLLLCTTFVYLYDAVMGPEWDDGLPYFTAFYFSFISLTTIGLGDVMPNNV 415

  Fly   817 PFYVMVSMIYLMFGLALTSMFINVVQIKLSDH----FKMASAKVGATIGMNMTSELGDEGGSQVK 877
            |:...||||:.: |:|:|.:......|.:.:.    ..:|..|:         |.|..|....||
Worm   416 PYAPPVSMIFFI-GMAVTKVVNRATFIAVENGVFGLMTLAETKI---------SMLLTERKPGVK 470

  Fly   878 TPSELASVHGSRLDRIEE------DGQEANGNGHSPVPPL------TSILRAPRPLSPASNGVDA 930
            |....:|  ||..:.::.      ||...:|:....:...      |..:|:......:::.|..
Worm   471 TVRSTSS--GSSAESVDSKEPRGFDGDSDSGSDDGVINRRRNEMMNTFTVRSIATFMRSNHDVYG 533

  Fly   931 NGVGADAVGAGDV 943
            .|.|...:..||:
Worm   534 GGFGRVQLRRGDL 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	23/55 (42%)
		Ion_trans_2	771..847	CDD:285168	32/84 (38%)
twk-36	NP_507485.2	Ion_trans_2	255..322	CDD:285168	23/66 (35%)
		Ion_trans_2	361..432	CDD:285168	30/71 (42%)
		Ion_trans	<363..452	CDD:278921	32/89 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.770