DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34396 and twk-42

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_507483.1	Gene:	twk-42 / 180163	WormBaseID:	WBGene00006692	Length:	444	Species:	Caenorhabditis elegans

Alignment Length:	417	Identity:	105/417 - (25%)
Similarity:	176/417 - (42%)	Gaps:	83/417 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   505 WKRLKLDYPQKVKELRQLRNRCIAYLICMAMLLGFGGLLFRYTEGAAENIYKCEVR--------K 561
            |..:.::|     |...|.:.....::.:...||.|  ||...|...|...|.|..        .
Worm     3 WNLVAVNY-----ERYHLHHLVKIGVLIVYSFLGAG--LFVLCEAENEKSLKHEDNMRVLRTSIA 60

  Fly   562 VKRDFIDRLWDVSHNMREEDWKS--LARQKLRSFEDELNNLAELGLRRYPGQKS-WNFVNCFIFC 623
            .|:.|:.||    .||...:..|  .:..|||....|.:  |.:|:......|: |:......:.
Worm    61 AKQVFVQRL----QNMYSGNGSSSEFSETKLRRVLSEYD--AAMGISIDSKMKTRWDIWGGLYYA 119

  Fly   624 WTVITTIGYGHITPKTGMGRSLTIVYAIIGIPMFLIVLADLGKLFTRCVKFLWVYVRRMYYTRSC 688
            .|:.||||||.:..:|..||..|::||:||||:.:.:|.|.|.:....|...|..:.|. :.:|.
Worm   120 GTIYTTIGYGDLAAETIWGRICTMLYAMIGIPIVINILNDWGNMLFYFVDHFWQNIGRQ-WIQSL 183

  Fly   689 RRIRKQQQIRSAMTGFNTMYDMAIRRPSMFFSNSAPENDEESQADAEAARSVGTSHPETP--TSP 751
            |:..::::::|...|       :|.:..:..::|.|.:                  |:.|  |.|
Worm   184 RQKLRRRKVQSLEEG-------SIDKTPLMETSSTPPS------------------PQNPNGTRP 223

  Fly   752 YPETFEVDDEFNLPVSVASLLLITYILLGSFGFLMME--------PSWTPLDAFYYVFISMSTIG 808
            .|                 |||:..:|.    |.|::        .:||..::.|:.||||:|||
Worm   224 IP-----------------LLLVLIVLF----FWMIQCVAYFAYFENWTLFESVYFFFISMTTIG 267

  Fly   809 FGDLVPSNPFYVMVSMIYLMFGLALTSMFINVVQIKLSDHFKMASAKVGATIGMNMTSELGDEGG 873
            |||..||:...| ..:::::.||::.||.|||:|::|...|.....::.... .|..|...:|..
Worm   268 FGDFTPSHTVAV-GGIVFILGGLSVVSMCINVIQMQLEFIFNQIVQRIENDF-KNTLSVAAEESR 330

  Fly   874 SQVKTPSELASVHGSRLDRIEEDGQEA 900
            .:....||..|:..|:...:..||..|
Worm   331 KKSIGVSEFGSIDPSKKKTMRTDGNVA 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	21/55 (38%)
		Ion_trans_2	771..847	CDD:285168	31/83 (37%)
twk-42	NP_507483.1	Ion_trans_2	<109..165	CDD:285168	21/55 (38%)
twk-42	NP_507483.1	Ion_trans_2	236..304	CDD:285168	25/68 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.770