DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34396 and twk-11

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_504783.2	Gene:	twk-11 / 179088	WormBaseID:	WBGene00006666	Length:	1720	Species:	Caenorhabditis elegans

Alignment Length:	436	Identity:	115/436 - (26%)
Similarity:	191/436 - (43%)	Gaps:	110/436 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   530 LICMAMLLGFGGLLFRYTE-----GAAENIYKCEVRKVKRD---------FIDRLWDVSHNMREE 580
            ||.:.:....|..:|.|.|     .|.|:.:  ..||:.|:         |.|...|     |||
Worm    79 LIIIGLYSFIGAHIFMYLEVPTDLEAREDGF--HQRKIAREVMVLNLRAIFYDNRED-----REE 136

  Fly   581 DWKSLARQKLRSFEDELNNLAELGLRRYPGQKSWNFVNCFIFCWTVITTIGYGHITPKTGMGRSL 645
            .||    ..:..||:      ::||.....:..|.|...|::..|:.||||||:|..||..|:..
Worm   137 RWK----HAILKFEE------DIGLEEPVIETVWTFWMSFLYAGTIFTTIGYGNIACKTRAGQIA 191

  Fly   646 TIVYAIIGIPMFLIVLADLG-------KLFTRCVKFLWVYV---------------RRMYYTRSC 688
            |:|||.:|||:.|::|..|.       ||.|..|..:.:|:               :|:.||:..
Worm   192 TMVYAFVGIPIMLVMLTSLNNFLLKWIKLITNGVSDMTLYIGVRLGITVIRQDEVQKRLRYTKLA 256

  Fly   689 RRIRKQQQIRSAMTGFNTMYDMAIRRPSMFFSNSAPENDEESQADAEAARSVGTSHPETPTSPYP 753
            :.::     |..::.......:||........||.||:|||.:          ..|.:.|
Worm   257 KTMK-----RWKLSKHGAPSSIAISNSEENRLNSTPEDDEEEE----------EIHQDPP----- 301

  Fly   754 ETFEVDDEFNLPVSVASLLLIT--YILLGSFGFLMMEPSWTPLDAFYYVFISMSTIGFGDLVPSN 816
                          |.|.|:.|  :|:|.:..|.:.| .||...:||:.|||::|||.||:.|:|
Worm   302 --------------VLSTLIATVAWIILSAAVFCLFE-DWTFFTSFYFCFISLTTIGLGDVTPAN 351

  Fly   817 PFYVMVSMIYLMFGLALTSMFINVVQIKLSDHFK----------MASAKVGATIGMNMTSEL--G 869
            |.|::.:...::.||::.::.|:|:|.||:..:.          |.:.|.|   ..|..|.:  |
Worm   352 PEYMIATFGVVIVGLSMLTVCIDVLQEKLAQMYMALLQKLLTEYMEAVKSG---DPNAASAMMAG 413

  Fly   870 DEGGSQVKTPSELASVHGSR-LDRIEEDGQEANGNGHSPVPPLTSI 914
            .:|.::...|. ::...|:: :|:.::|   .:..|..|.|.||:|
Worm   414 FQGRAKFLMPL-ISKNEGAKVMDKFKQD---CSKKGIDPPPVLTNI 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	26/62 (42%)
		Ion_trans_2	771..847	CDD:285168	29/77 (38%)
twk-11	NP_504783.2	Ion_trans_2	156..216	CDD:285168	24/59 (41%)
		Ion_trans	<305..384	CDD:278921	29/79 (37%)
		Ion_trans_2	307..382	CDD:285168	28/75 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920