DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34396 and twk-8

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001023596.1	Gene:	twk-8 / 177727	WormBaseID:	WBGene00006663	Length:	769	Species:	Caenorhabditis elegans

Alignment Length:	519	Identity:	128/519 - (24%)
Similarity:	208/519 - (40%)	Gaps:	134/519 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 RSSSLERPLRPKRSGS---LERKEQVTQELLEGTTTNEADTEPKSLGDQPLLPEESISEAKPKVT 454
            |||:..|.|||....|   |.|..|::.......|.:       |.||:..:.:..|.:.:|:|.
Worm    12 RSSNTNRNLRPSSGASGDRLRRPSQMSAGAQSSATRH-------SQGDKDKVVQSRIHDQEPEVK 69

  Fly   455 LWQRLKNLFRRKKKIQAKGEDVTDLSTELPLEKLASRGLLYSFSLEARHEWKRLKLDYPQKVKEL 519
            ..:...|.|.|..|                                   |: .:|..:|
Worm    70 EPETWGNRFHRMYK-----------------------------------EY-HIKYLFP------ 92

  Fly   520 RQLRNRCIAYLICMAMLLGFGGLLFRYTE-GAAENIYKCEVRKVKRD------FIDRLWDVSHNM 577
                      ||.:...:..|.::|...| |.||:....|..|.||:      .::.|...:.:.
Worm    93 ----------LIFIMFYMLIGAIIFYLLESGTAEDAANEEDYKYKRERRLLLLRMEELVQDTASR 147

  Fly   578 REEDWKSLARQKLRSFEDELNNLAELGLRRYPGQKSWNFVNCFIFCWTVITTIGYGHITPKTGMG 642
            |....|....:.:.::|.:|:...:       .:..|.|::...|..|:.||||||.|...|..|
Worm   148 RRAYRKKALEEAIDNYEQKLDFAVK-------NESQWTFMSAMYFAGTLFTTIGYGDIACITSAG 205

  Fly   643 RSLTIVYAIIGIPMFLIVLADLGKL----FTRCVKFLWVYVRRMYYTRSCRR-----IRKQQQIR 698
            |..|::|:.:|||..||.|.||||.    ...|||....:...:...|.|.|     .:|..::.
Worm   206 RIATVIYSCVGIPFMLITLNDLGKFLYNNINGCVKGFEDFTTYLGAFRLCNRRGNGNFQKGDELV 270

  Fly   699 SAMTGFNTMYDMAIRRPSMFFSNSAPENDEESQADAEAARSVGTSHPETPTSPYPETFEVDDEFN 763
            :...|.....|             |||       .:..|..:|:...|   |.| |..|.::|.:
Worm   271 TLEAGTTGTTD-------------APE-------VSSLASELGSERNE---SDY-EDIEDEEERS 311

  Fly   764 LP---VSVASLLLITYILLGSFGFLMMEPSWTPLDAFYYVFISMSTIGFGDLVPSNPFYVMVSMI 825
            :|   |.||..:.:.:|...|..|.:.| .|:...:.|::|||:||||.||:.......:::..:
Worm   312 MPRMSVKVALGITVGWIFFCSALFKLWE-DWSYGQSCYFMFISLSTIGLGDVSVQRRDMMVLCFV 375

  Fly   826 YLMFGLALTSMFINVVQIKLSDHF-------------KMASA--KVGATIGM------NMTSEL 868
            :::.||:|.||.|||:|:.|.|.:             |||:.  ::||::||      |.|::|
Worm   376 FVIVGLSLVSMTINVIQVALEDFYVNLIMKLILDYQEKMAAGGDQMGASVGMMRMWGNNKTAKL 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	26/59 (44%)
		Ion_trans_2	771..847	CDD:285168	25/75 (33%)
twk-8	NP_001023596.1	Ion_trans_2	169..233	CDD:285168	26/70 (37%)
twk-8	NP_001023596.1	Ion_trans_2	323..397	CDD:285168	25/74 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920