DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34396 and Kcnk5

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_067517.1	Gene:	Kcnk5 / 16529	MGIID:	1336175	Length:	502	Species:	Mus musculus

Alignment Length:	436	Identity:	93/436 - (21%)
Similarity:	163/436 - (37%)	Gaps:	139/436 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   530 LICMAML--LGFGGLLFRYTE-----GAAENIYKCEVRKVKRDFIDRLWDVSHNMREEDWKSLAR 587
            |:..|::  |..|..:|...|     .|.:|.|..::..:|                 ::..|::
Mouse     7 LLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLK-----------------EFPCLSQ 54

  Fly   588 QKLRSFEDELNNLAELGLRRYPGQ--KSWNFVNCFIFCWTVITTIGYGHITPKTGMGRSLTIVYA 650
            :.|......:::.|:.|:.....|  .:||:.|..||..|||||||||::.|||..||...:.|.
Mouse    55 EGLDKILQVVSDAADQGVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYG 119

  Fly   651 IIGIPMFLIVLADLGKLFTRCVKFLWVYVRRMYYTRSCRRIRKQQQIRSAMTGFNTMYDMAIRRP 715
            :.|:|:.|..::.|||.|....|.|     ..:.||....:||.|
Mouse   120 LFGVPLCLTWISALGKFFGGRAKRL-----GQFLTRRGVSLRKAQ-------------------- 159

  Fly   716 SMFFSNSAPENDEESQADAEAARSVGTSHPETPTSPYPETFEVDDEFNLPVSVASLLLI----TY 776
                                                              ::..::.::    .:
Mouse   160 --------------------------------------------------ITCTAIFIVWGVLVH 174

  Fly   777 ILLGSFGFLMMEPSWTPLDAFYYVFISMSTIGFGDLV----PSNPFYVMVSM---IYLMFGLALT 834
            :::..|.|::.| .|..::..||.||::|||||||.|    ||..::.:...   :::..|||..
Mouse   175 LVIPPFVFMVTE-EWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWL 238

  Fly   835 SMFIN-----VVQI---------------KLSDHFKMASAKVGATIG--MNMTSELGDEGGSQVK 877
            |:|:|     .|::               :.|.|.:.|....|:|..  :|:.|.|    ..:.:
Mouse   239 SLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQMAGSTASKDVNIFSFL----SKKEE 299

  Fly   878 TPSELASVHGSRLDRIEEDGQEANGNGHSPVPPLTSILRAPRPLSP 923
            |.::|....|.:..:....|:...|.||...|....:...|..|:|
Mouse   300 TYNDLIKQIGKKAMKTSGGGERVPGPGHGLGPQGDRLPTIPASLAP 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	27/55 (49%)
		Ion_trans_2	771..847	CDD:285168	25/106 (24%)
Kcnk5	NP_067517.1	Ion_trans_2	<81..137	CDD:285168	26/55 (47%)
Kcnk5	NP_067517.1	Ion_trans_2	171..243	CDD:285168	23/72 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810