DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34396 and Kcnk2

DIOPT Version :9

Sequence 1:NP_611547.2 Gene:CG34396 / 37398 FlyBaseID:FBgn0085425 Length:975 Species:Drosophila melanogaster
Sequence 2:NP_001153322.1 Gene:Kcnk2 / 16526 MGIID:109366 Length:426 Species:Mus musculus


Alignment Length:464 Identity:102/464 - (21%)
Similarity:164/464 - (35%) Gaps:167/464 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   529 YLICMAMLLGFGGLLFRYTEGAAENIYKCEVRKVKRDFIDRLWDVSH---NMREEDWKSLARQKL 590
            :|:.:..|: .|..:|:..|...|...:..:...|:.||     ..|   |..|.|  .|.:|.:
Mouse    66 FLVVVLYLI-IGATVFKALEQPQEISQRTTIVIQKQTFI-----AQHACVNSTELD--ELIQQIV 122

  Fly   591 RSFEDELNNLAELGLRRYPGQKS-WNFVNCFIFCWTVITTIGYGHITPKTGMGRSLTIVYAIIGI 654
            .:.     |...:.|.....|.| |:..:.|.|..|||||||:|:|:|:|..|:...|:||::||
Mouse   123 AAI-----NAGIIPLGNSSNQVSHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGI 182

  Fly   655 PMFLIVLADLGKLFTRCVKFLWVYVRRMYYTRSCRRIRKQQQIRSAMTGFNTMYDMAIRRPSMFF 719
            |:|..:||.:|                             .|:       .|::...|.:     
Mouse   183 PLFGFLLAGVG-----------------------------DQL-------GTIFGKGIAK----- 206

  Fly   720 SNSAPENDEESQADAEAARSVGTSHPETPTSPYPETFEVDDEF-NLPVSVASLLLITYILLGSFG 783
                                                  |:|.| ...||...:.:|:.|:...||
Mouse   207 --------------------------------------VEDTFIKWNVSQTKIRIISTIIFILFG 233

  Fly   784 FLMME----------PSWTPLDAFYYVFISMSTIGFGDLVPSN------PFYVMVSMIYLMFGLA 832
            .::..          ..|:.|||.|:|.|:::||||||.|...      .||..|...:::.|||
Mouse   234 CVLFVALPAVIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLA 298

  Fly   833 LTSMFINVVQIKLSDHFKMASAKVGATIG----------MNMTSELGD-------------EGGS 874
            ..:..::::    .|..::.|.|....:|          .|:|:|..:             :..:
Mouse   299 YFAAVLSMI----GDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRAT 359

  Fly   875 QV--KTPSELASVHGSRLDRIEEDGQEANGNGHSP------VPPLTSILRAPRPLSPAS----NG 927
            .|  |..:|||..|...|               :|      |..|||......||..|.    ||
Mouse   360 SVKRKLSAELAGNHNQEL---------------TPCRRTLSVNHLTSEREVLPPLLKAESIYLNG 409

  Fly   928 VDANGVGAD 936
            :..:..|.|
Mouse   410 LTPHCAGED 418

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34396NP_611547.2 RILP-like 135..>217 CDD:304877
Ion_trans_2 <614..670 CDD:285168 25/55 (45%)
Ion_trans_2 771..847 CDD:285168 24/91 (26%)
Kcnk2NP_001153322.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
Ion_trans_2 <139..196 CDD:285168 26/85 (31%)
Ion_trans_2 234..312 CDD:285168 21/81 (26%)
Required for basal channel activity 369..426 16/65 (25%)
Essential for chloroform and halothane sensitivity 393..426 7/26 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1418
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000030
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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