DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34396 and KCNK7

DIOPT Version :9

Sequence 1:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_203133.1	Gene:	KCNK7 / 10089	HGNCID:	6282	Length:	307	Species:	Homo sapiens

Alignment Length:	383	Identity:	77/383 - (20%)
Similarity:	136/383 - (35%)	Gaps:	133/383 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   527 IAYLICMAMLLGFGGLLFRYTEGAAENIYKCEVRKVKRDFIDRLWDVSHN-------MREEDWKS 584
            :|:|:.    ||.|.::|:..||......:.|:|.....|     ...|.       :.|....:
Human    15 VAHLLA----LGLGAVVFQALEGPPACRLQAELRAELAAF-----QAEHRACLPPGALEELLGTA 70

  Fly   585 LARQKLRSFEDELNNLAELGLRRYPGQKSWNFVNCFIFCWTVITTIGYGHITPKTGMGRSLTIVY 649
            ||.|        .:.::.||  .....::|:..:..:|..:::||.||||:.|.:..|::..:||
Human    71 LATQ--------AHGVSTLG--NSSEGRTWDLPSALLFAASILTTTGYGHMAPLSPGGKAFCMVY 125

  Fly   650 AIIGIPMFLIVLADLGKLFTRCV------KFLWVYVRRMYYTRSCRRIRKQQQIRSAMTGFNTMY 708
            |.:|:|..|.::|.|    ..|:      ...||.|.                           :
Human   126 AALGLPASLALVATL----RHCLLPVLSRPRAWVAVH---------------------------W 159

  Fly   709 DMAIRRPSMFFSNSAPENDEESQADAEAARSVGTSHPETPTSPYPETFEVDDEFNLPVSVASLLL 773
            .::..|.::.            ||                                 |::..|:.
Human   160 QLSPARAALL------------QA---------------------------------VALGLLVA 179

  Fly   774 ITYILLGSFGFLMMEPSWTPLDAFYYVFISMSTIGFGDLVPS-----NPFYVMVSMI----YLMF 829
            .:::||.:.....::...:.|.|.|:.|.|:||||..||:|.     :|....:..:    ||:.
Human   180 SSFVLLPALVLWGLQGDCSLLGAVYFCFSSLSTIGLEDLLPGRGRSLHPVIYHLGQLALLGYLLL 244

  Fly   830 G----LALTSMFINVVQIKLSDHFKMASAKVGATIGMNMTSELGDEGGSQVKTPSELA 883
            |    |.....|..:.|::....|...|..|        |:|  |:||  :....|||
Human   245 GLLAMLLAVETFSELPQVRAMGKFFRPSGPV--------TAE--DQGG--ILGQDELA 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877
		Ion_trans_2	<614..670	CDD:285168	18/55 (33%)
		Ion_trans_2	771..847	CDD:285168	22/88 (25%)
KCNK7	NP_203133.1	Ion_trans_2	<90..140	CDD:285168	17/49 (35%)
KCNK7	NP_203133.1	Ion_trans_2	182..>220	CDD:285168	13/37 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155178
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740