Protein Alignment Rbpn-5 and RABEP1

DIOPT Version :10

• Sequence 1: NP_611545.1
• Gene: Rbpn-5 / 37395
• FlyBaseID: FBgn0034585
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_011522362.1
• Gene: RABEP1 / 9135
• HGNCID: 17677
• Length: 884
• Species: Homo sapiens
• Alignment Length: 735
• Identity: 170/735 - (23%)
• Similarity: 312/735 - (42%)
• Gaps: 190/735 - (25%)

  Fly     3 ENETRSEAREPTD------LPNGEDDATSQHKLSHLQNEMRKMQNEFNTQRAKMREL--YIQKE- 58
            |||.: :|:|..:      :|..::.|..:.||:..:::::::      :.:|::||  |::.|
Human   171 ENEMK-KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKEL------EASKVKELNHYLEAEK 228

  Fly    59 --------------AEVSQSQQERRQLQAELDELKTHLMVADLKSQNELQ--------------- 94
                          .:.|..|::..:|:.||.|: .||:..:.:..|:|:
Human   229 SCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEV-CHLLEQERQQHNQLKHTWQKANDQFLESQR 292

  Fly    95 --LRDLKAQEEISSLQQLVQDTIEETA-----------------HYKGEVERLRLELGKYQQIQQ 140
              :||::..|.:.:.:||.|  :||..                 |.|.:||         ::|:.
Human   293 LLMRDMQRMEIVLTSEQLRQ--VEELKKKDQEDDEQQRLNKRKDHKKADVE---------EEIKI 346

  Fly   141 QTMAQQPQAESSGGIA-----------------PQV----LNQVKKTLGSVRKL----------- 173
            ..:....|.|||..::                 |:|    |..:..|.|||..|
Human   347 PVVCALTQEESSAQLSNEEKTPFKIKITDRSSYPEVTTNILEHLDSTRGSVHSLDAGLLLPSGDP 411

  Fly   174 -----------------GTDSLNSSFQQDE-----DTRASSKGN----------GKQYAPEEAE- 205
                             .||||.:|.....     :.:|.|.||          |.....|..:
Human   412 FSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDT 476

  Fly   206 ------MMHSIVEQLQEEMKALKVKLREQDEQ---LQAKSASDESA--------LHKSTSMDVAE 253
                  .|.|.....:::.:|:|....||:|.   |.:.:...|||        |...|..::.:
Human   477 ASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQ 541

  Fly   254 S-----------ACESCSLAEKKTEELGAHINKQQKQVDLLQKQLVESRETLVKEAALRKDLEDQ 307
            .           .|:.||..||:.:.:.....:.:.||..||..|.::.:.|.|....:::|||.
Human   542 KEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 606

  Fly   308 WQEKREAHKSEVQSLRDQAKTNEQRLLDMQQKFLETKDEVIKQIQRVSDDRERVNKQLETLQADN 372
            .::..|....::.:|..:|:.:|..|.::||...:.|.:|.:|:..:...||:|:::|..||.||
Human   607 IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDN 671

  Fly   373 DFLSGRY-LATSEEIDNQYINLPNTVVELQELILRQQSELIQARVSSEYERQKCTSTEDEIQILR 436
            |.|.|:: |..|.:....:| ||:|...|:||:|:.:.::|..|.::::..:|..:   ||..|:
Human   672 DSLQGKHSLHVSLQQAEDFI-LPDTTEALRELVLKYREDIINVRTAADHVEEKLKA---EILFLK 732

  Fly   437 AQLEESNNERRAYKRKMQLDIKSLQDR---VTEHLVTVQAYETTKTQLERKEAELNKQLSECRVE 498
            .|::.....:...:..:||:|::.::.   ::.....::..:..|.|||....|.::||...:..
Human   733 EQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEI 797

  Fly   499 IIELQEANEKYAKTNA-------DYKTKIKTLQEELSTMETVQKDFVKLSQTLQMSLEELRHADT 556
            .|.|:|..:|.....|       :.|.|.:.||.||...|.||:||||||||||:.||.:|.||:
Human   798 KISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS 862

  Fly   557 --EVRWQDDD----DVNNCP 570
              .:|...:|    |:|..|
Human   863 LERIRAILNDTKLTDINQLP 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbpn-5	NP_611545.1	Rabaptin	22..>374	CDD:367545	100/495 (20%)
		Rab5-bind	256..555	CDD:462752	90/309 (29%)
		FYVE_RABE_unchar	557..629	CDD:277278	5/18 (28%)
RABEP1	XP_011522362.1	Rabaptin	9..517	CDD:367545	68/364 (19%)
		Rab5-bind	555..861	CDD:462752	90/309 (29%)