Protein Alignment Rbpn-5 and EEA1

DIOPT Version :10

• Sequence 1: NP_611545.1
• Gene: Rbpn-5 / 37395
• FlyBaseID: FBgn0034585
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_011537116.1
• Gene: EEA1 / 8411
• HGNCID: 3185
• Length: 1453
• Species: Homo sapiens
• Alignment Length: 775
• Identity: 161/775 - (20%)
• Similarity: 321/775 - (41%)
• Gaps: 192/775 - (24%)

  Fly     8 SEAREPTDLPNGEDDATSQHKLSHLQNEMRKMQNEFNTQRAKM---RELYIQKEAEVSQSQQERR 69
            ::..:..||.|..|  |:|:.|...|.|:.|:..:.:...||:   :|...|.|:.:.:.:::..
Human   699 AKTAQRADLQNHLD--TAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 761

  Fly    70 QLQAELDELKTHL--MVAD---LKSQNELQLRDLKAQEEISSLQQLVQDTIEETAHYKGE-VERL 128
            .|:.:.:||:..:  :.||   :|:..|..|:||:.|.::::..:|....:.:....:.| |...
Human   762 SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSST 826

  Fly   129 RLELGK----YQQIQQQTMAQQPQAESSGGIAPQVLNQVKKTLGSVRKLGTDSLNSSFQ------ 183
            ||:|.|    .:.|:|:...|:.:        .::|.|..:||....|:..:.||:..|
Human   827 RLDLQKKSEALESIKQKLTKQEEE--------KKILKQDFETLSQETKIQHEELNNRIQTTVTEL 883

  Fly   184 -----------------QDEDTRAS-SKGNGKQYAPEEAEMMHSIVEQLQEEMKALKVKLREQDE 230
                             :|:.::.| |..|.|....:|.:...:.:..|::..|.||.:|:.|.|
Human   884 QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQME 948

  Fly   231 QL------------QAKSASDESALHKSTSMDVAESACESCSLAEKKTEELGAHIN-------KQ 276
            ..            :.|.||.:..|..::..:....|..:....||:.::|..:||       ::
Human   949 NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK 1013

  Fly   277 QKQVDL------------------LQKQLVESRETLVKEAALRKDLEDQWQEKREAHK------- 316
            :||::.                  ||:||.::.:.|..|......|::.:::.:|..|
Human  1014 KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFY 1078

  Fly   317 ---SEVQSLRDQAKTNEQRLLDMQQKFLETKDEVIKQIQRVSD----------DRERVNKQL-ET 367
               ||:.:.|...|:.|::|...|:..:..::::..|.:.:.:          |..:..:|| |.
Human  1079 GRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQER 1143

  Fly   368 LQADNDFLSGRYLATSEEIDNQYINLPNTVVELQELILRQQSELIQARVSSEYERQKCTSTED-- 430
            .:|..|....:.|.     :.:.:|..:.:.|::|:..||:.|:  .:::.|.:..|..|.::
Human  1144 CKALQDIQKEKSLK-----EKELVNEKSKLAEIEEIKCRQEKEI--TKLNEELKSHKLESIKEIT 1201

  Fly   431 --------------EIQ----ILRAQLEESNNERRAYK---RKMQLDIK--------SLQDRVTE 466
                          |:|    .|:|.:|:....::..|   :|.:.::|        .|...:.|
Human  1202 NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKE 1266

  Fly   467 HLVTVQAYETTKTQL---------------------ERKEAELNKQLSECRVEIIELQEANEKYA 510
            ..|.::.:|..:.:|                     :|:.:||.||..:.|.||..|    |...
Human  1267 KEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVL----EATV 1327

  Fly   511 KTNAD------------------YKTKIKTLQEELSTMETVQKDFVKLSQTLQMSLEELRHADT- 556
            :.|.|                  .:||:..||.:|.......::..:.:|:||     ::|...
Human  1328 QNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ-----IKHTQAL 1387

  Fly   557 EVRWQDDDDVNNCPTCNAYFTVMVRKIHCRHCGHIYCDKCLTKTVPSGPRKRVARVCDIC 616
            ..:|.:|::|.||..|...|:|.||:.|||.||:|:|.:|..|...:...|:..||||.|
Human  1388 NRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDAC 1447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbpn-5	NP_611545.1	Rabaptin	22..>374	CDD:367545	87/446 (20%)
		Rab5-bind	256..555	CDD:462752	74/414 (18%)
		FYVE_RABE_unchar	557..629	CDD:277278	25/60 (42%)
EEA1	XP_011537116.1	GumC	<117..>349	CDD:442439
		SMC_prok_B	<285..1006	CDD:274008	67/316 (21%)
		SMC_prok_B	651..>1382	CDD:274008	135/708 (19%)
		FYVE_EEA1	1389..1451	CDD:277269	25/59 (42%)