Protein Alignment Rbpn-5 and Rabep1

DIOPT Version :10

• Sequence 1: NP_611545.1
• Gene: Rbpn-5 / 37395
• FlyBaseID: FBgn0034585
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_062273.2
• Gene: Rabep1 / 54189
• MGIID: 1860236
• Length: 862
• Species: Mus musculus
• Alignment Length: 861
• Identity: 172/861 - (19%)
• Similarity: 316/861 - (36%)
• Gaps: 313/861 - (36%)

  Fly    17 PNGEDDATSQHKLSHLQ-------NEMRKMQNEFNTQRAKMRELYIQKEAE------VSQSQQE- 67
            |..:.|.:.|.:::.|:       ...::::.|||.:|||.:|||:.||.:      |.|:.|:
Mouse     6 PAPQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70

  Fly    68 ----RRQL---QAELDELKTHLMVADLKSQNELQLRDLKAQ--EEISSLQQLVQDTIEETAH-YK 122
                |.||   |||::.:|....|::...|..:.  ::|.|  ||::|||.::::|:.:..| :.
Mouse    71 LGHLRTQLWEAQAEMENIKAIATVSENTKQEAID--EVKRQWREEVASLQAIMKETVRDYEHQFH 133

  Fly   123 GEVERLRLELGKYQQIQQQTMAQQPQAESSGGIAPQVLNQVKKTLGSVRKLGT------------ 175
            ..:|:.|.:..:|::..::.:|...:..|.|.....:.|::||......||.:
Mouse   134 LRLEQERAQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAAL 198

  Fly   176 -DSLNSSFQQDEDTRASS------------------------KGNGKQYAPEEAEM----MHSIV 211
             |.|..:..:.::..||.                        ....|....|:||.    :|.:.
Mouse   199 KDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVC 263

  Fly   212 EQLQEE-------------------------------------------MKALKVKLREQDEQ-- 231
            ..|::|                                           ::.||.|.:|:|||
Mouse   264 HLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDEQQR 328

  Fly   232 ----------------------------------------------------------------- 231
                                                                             
Mouse   329 VNKRKDNKKTDTEEEVKIPVVCALTQEESSTPLSNEEEHLDSTHGSVHSLDADLMLPSGDPFSKS 393

  Fly   232 --------------------------------LQAKSA--------------------------- 237
                                            .:||||
Mouse   394 DNDMFKDGLRRAQSTDSLGTSSSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTVSLG 458

  Fly   238 ------------------------SDESALHKSTSMDVAESA----------------------- 255
                                    .:|:|...|:.....|||
Mouse   459 SLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVH 523

  Fly   256 ---------CESCSLAEKKTEELGAHINKQQKQVDLLQKQLVESRETLVKEAALRKDLEDQWQEK 311
                     |:.||..||:.:.:.....:.:.||..||..|.::.:.|.|....:::|||..::.
Mouse   524 NAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKEKQELEDFLKQS 588

  Fly   312 REAHKSEVQSLRDQAKTNEQRLLDMQQKFLETKDEVIKQIQRVSDDRERVNKQLETLQADNDFLS 376
            .|....::.:|..:|:.:|..|.::||.|.:.|.:|.:|:..:...||:|:::|..||.|||.|.
Mouse   589 AEDSSHQISALVLRAQASEVLLEELQQSFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQ 653

  Fly   377 GRY-LATSEEIDNQYINLPNTVVELQELILRQQSELIQARVSSEYERQKCTSTEDEIQILRAQLE 440
            |:: |..|.::...:| ||:||..|:||:|:.:..::..|.::::..:|..:   ||..|:.|::
Mouse   654 GKHSLHVSLQLAEDFI-LPDTVEVLRELVLKYRENIVHVRTAADHMEEKLKA---EILFLKEQIQ 714

  Fly   441 ESNNERRAYKRKMQLDIKSLQDR---VTEHLVTVQAYETTKTQLERKEAELNKQLSECRVEIIEL 502
            .....:...:..:||:|::.::.   ::.....::..:..|.|||....|.::||...:...:.|
Mouse   715 AEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEMKVNL 779

  Fly   503 QEANEKYAKTNA-------DYKTKIKTLQEELSTMETVQKDFVKLSQTLQMSLEELRHADT--EV 558
            :|..:|.....|       :.|.|.:.||.||...|.||:||||||||||:.||.:|.||:  .:
Mouse   780 EEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERI 844

  Fly   559 RWQDDD----DVNNCP 570
            |...:|    |:|..|
Mouse   845 RAILNDTKLTDINQLP 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbpn-5	NP_611545.1	Rabaptin	22..>374	CDD:367545	108/641 (17%)
		Rab5-bind	256..555	CDD:462752	90/309 (29%)
		FYVE_RABE_unchar	557..629	CDD:277278	5/18 (28%)
Rabep1	NP_062273.2	Rabaptin	9..495	CDD:367545	71/487 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	315..374		7/58 (12%)
		Rab5-bind	533..839	CDD:462752	90/309 (29%)