Protein Alignment Rbpn-5 and eea-1

DIOPT Version :10

• Sequence 1: NP_611545.1
• Gene: Rbpn-5 / 37395
• FlyBaseID: FBgn0034585
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_001024127.1
• Gene: eea-1 / 179832
• WormBaseID: WBGene00011696
• Length: 1205
• Species: Caenorhabditis elegans
• Alignment Length: 924
• Identity: 189/924 - (20%)
• Similarity: 331/924 - (35%)
• Gaps: 316/924 - (34%)

  Fly     3 ENETRSEAREPTDLPNGEDDAT-SQHKLSH-LQNEMRKMQNE-----------------FNTQRA 48
            |.|.:....|..:...||.:.| .|.::|: .|:|..|.:||                 .|.|..
 Worm   286 EREKQHIVNENLEKKIGEGEETVKQLQISYDAQSEELKQRNERVVQLEARIEENVFELSENKQNV 350

  Fly    49 KMRELYIQKEAEVSQ----------------------SQQERRQLQAELDE--------LKTHLM 83
            |..|..:|:..:..|                      :..||::::|..:|        ||| |.
 Worm   351 KRLEDKVQESQDALQMLSNINGSNEEQMISLNSKFERNTAERKRIEAVFEEKVTVQGERLKT-LE 414

  Fly    84 VADLKSQNEL--------QLRDL--KAQEEISSLQQLVQDTIEETAH-------YKGE------- 124
            :|:|...|||        :.|.|  :..:|||.....:.|..|:.|.       ||.|
 Worm   415 MANLDLTNELASMGSLLDKERSLLEEKNKEISERDSSINDLKEKLAESEKKATKYKNELKEHADL 479

  Fly   125 VERLRLELGKYQQIQQQTMAQQPQAESSGGIAPQVLNQVK-------KTLGSVRKLGTDSLNSSF 182
            ||.|.|:|.|.|:..:..|.:....|....:|.:.|.|.|       :|.....|..:..|.:..
 Worm   480 VENLTLQLNKLQENSKDLMEKISAGEGGAKMAIEQLEQEKVKLTNELQTSSEKTKKASGELEAKI 544

  Fly   183 QQDE----DTRASSKGNGKQYAPEEAEMMHSIVE-------------QLQEEM---------KAL 221
            .:.|    |..||.....:::..|:......:.|             ::::||         :.|
 Worm   545 SELEKKLRDAEASRTDKEQKWKQEKESFERKLAEAEDEIKRKGERFVEMEKEMEEERQKATDRTL 609

  Fly   222 KVK-----------------------LREQDEQLQAKSASDESALHK--------------STSM 249
            |:|                       :||:|..|:......|.|:.|              .:|.
 Worm   610 KLKDALVNSEKNLETIKKESEDREKIVREKDAHLEENKKRIEDAVQKLEEAEKRARELEASVSSR 674

  Fly   250 DVAESACESCSLAEKKTE--ELGAHINKQQKQVDLLQKQLVESRETLVKEAALRKDLEDQWQEKR 312
            |...|..|| .|:|.|.:  |..:.|.:.:.||:.:..::.|.::.:....|..:|.|..|:.||
 Worm   675 DTTVSTKES-ELSELKGKLTESNSFIEELKVQVEKVSNEISEKQQEVENLMAEMRDKEAHWKTKR 738

  Fly   313 EAHKSEVQSLRDQAKTNE--QRLLDMQQKFLETK-----------------DEVIKQIQRVSDDR 358
            :  :.|.|.||:|....|  ..|..:|::.::.|                 :|:..:::|:....
 Worm   739 D--EFEAQMLRNQEDNEEASSTLKSVQEQLMKEKETSGEEKNQLISVKSQLEELKTEVERLIRSE 801

  Fly   359 ERVNKQLETLQA-------DNDFLSGRYLATSEEIDNQYINLPNTVVELQ--------------E 402
            |...:::|.|::       :.|.|:    ||||.:..:..||.:.:..::              |
 Worm   802 EEKTQEIEKLKSAVTATTQERDELT----ATSESLRTECENLNSKIQSIEESRRHAEEKGSENLE 862

  Fly   403 LILRQQSEL---IQARVS-------------SEYERQKCTS--TEDE-------IQILRAQLEES 442
            .::.::|.|   |:.|.|             :|.|..|.|.  .|||       |:...:::||.
 Worm   863 RMITEKSRLEKDIEERESTIQSIQEALETKDNEIESLKTTQRVVEDELVSKISHIESFNSRIEEF 927

  Fly   443 NNERRAYKR------------------------KMQLDIKSLQDRVTEHLVTVQAYETTKTQLER 483
            ..|..:.||                        :.|.:::.||..:.|...|:....::|||.|.
 Worm   928 EKEMASGKRTIERLEAEKAEETEKLVVFTGTQSQKQEELEKLQKEIQEKETTIARMTSSKTQFEA 992

  Fly   484 KEAE----LNKQLSECRVEIIELQEANEKYAKTN-----------ADYKTKIKTLQEELSTMETV 533
            ..|:    |:|::::...||..|.|..:...|.|           ...:..:::|:.:|:.:..:
 Worm   993 MFADVQQTLSKEINDKTEEIERLMERIDSLEKVNHSRIEELESRLTQRERVVESLEADLAAVRNI 1057

  Fly   534 QKDFVKLSQTLQMSLEELRHADT------------------------------------------ 556
            :::.:...|.|:...:||:.|:|
 Worm  1058 EQEKLDELQKLKEEFDELKKAETMWQAEKDMLIERCLGSESDIEYEKERSQENKRRFDDALSAMH 1122

  Fly   557 -----------------EVRWQDDDDVNNCPTCNAYFTVMVRKIHCRHCGHIYCDKCLTKTVPSG 604
                             ..:|.||.:..||..|...|::.|||.|||.||.|||:.|.:|:|...
 Worm  1123 ELGRANQSLQIDADRYSSRKWLDDAEAINCTECGKVFSLTVRKHHCRVCGKIYCNPCSSKSVRIA 1187

  Fly   605 PRKRVARVCDICHT 618
            ..|...|.|:.|.|
 Worm  1188 SAKNPVRACNTCFT 1201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbpn-5	NP_611545.1	Rabaptin	22..>374	CDD:367545	105/522 (20%)
		Rab5-bind	256..555	CDD:462752	81/404 (20%)
		FYVE_RABE_unchar	557..629	CDD:277278	26/62 (42%)
eea-1	NP_001024127.1	SMC_prok_B	163..1029	CDD:274008	155/750 (21%)
		ClpA	<1030..>1126	CDD:440308	8/95 (8%)
		FYVE_EEA1	1141..1203	CDD:277269	26/61 (43%)