DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht9 and Chia1

DIOPT Version :9

Sequence 1:	NP_611543.3	Gene:	Cht9 / 37392	FlyBaseID:	FBgn0034582	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_075675.2	Gene:	Chia1 / 81600	MGIID:	1932052	Length:	473	Species:	Mus musculus

Alignment Length:	393	Identity:	153/393 - (38%)
Similarity:	220/393 - (55%)	Gaps:	33/393 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKLLAL--LAVLCLSQVIGAERIVNCYWGTWANYRSGNGKFDVSNIDAGLCTHLSYSFFGINDN 63
            |.|||.:  ||:|..:|:..|..:: ||:..||.||.|.|.|...:|:..|||||.|:|.|:.:|
Mouse     1 MAKLLLVTGLALLLNAQLGSAYNLI-CYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQNN 64

  Fly    64 GEIQSLDTWLDYDLGFINQAIS-LKNQNSNLKVLAVVGGWNEGSTKYSSMSGDWYKRQNFINSAL 127
             ||.::: |.|..|   .:|.: |||:||.||.|..:||||.|:..:::|......||.||.|.:
Mouse    65 -EITTIE-WNDVTL---YKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVI 124

  Fly   128 NLLRNHGFDGLDLDWEYPNQRGGNWNDRANFVTLLREIKEAFAPYGYE-------LGIAVGAGES 185
            ..||.:||||||||||||..||....|:..|..|::|::|||.....|       :..||..|.|
Mouse   125 KFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMVTAAVAGGIS 189

  Fly   186 LASASYEIANIAQQVDFINVMTYDFAMASDGQTGFNAPQWA------------VENAINFWLSQG 238
            ...|.|||..:::.:|||:|||||...:.:|.||.|:|.:.            |:..:|:|.:.|
Mouse   190 NIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAYLNVDYVMNYWKNNG 254

  Fly   239 APANKLVLGVGTYGRSFQLSDSSQNWPGAPCRGEGSAGSYTGSTGYLGYNEIC---QNNWHTVFD 300
            |||.||::|...||.:|.|.:.|.|..|||..|:|.||.||...|:..|.|||   ::....|:|
Mouse   255 APAEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFLRSGATEVWD 319

  Fly   301 YDNAAPYAYSGDQWVSFDNVLSVQYKMDFALSKGLAGAMIWSLETDDYRGQ-CGE-TYPLLKTIN 363
            .....||||..::|:.:||:.|...|..:.......|||||:::.||:.|. |.: .:||..|:|
Mouse   320 ASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTLN 384

  Fly   364 RKL 366
            :.|
Mouse   385 KAL 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht9	NP_611543.3	GH18_chitolectin_chitotriosidase	23..366	CDD:119351	143/367 (39%)
Cht9	NP_611543.3	Glyco_18	23..346	CDD:214753	135/345 (39%)
Chia1	NP_075675.2	GH18_chitolectin_chitotriosidase	24..387	CDD:119351	143/368 (39%)
		Glyco_18	24..365	CDD:214753	135/346 (39%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	70..71		0/1 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	97..100		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	210..213		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421
		ChtBD2	426..473	CDD:214696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	339	1.000	Inparanoid score	I2351
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58170
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.980