DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht9 and CHIT1

DIOPT Version :9

Sequence 1:	NP_611543.3	Gene:	Cht9 / 37392	FlyBaseID:	FBgn0034582	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_003456.1	Gene:	CHIT1 / 1118	HGNCID:	1936	Length:	466	Species:	Homo sapiens

Alignment Length:	372	Identity:	147/372 - (39%)
Similarity:	210/372 - (56%)	Gaps:	31/372 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AERIVNCYWGTWANYRSGNGKFDVSNIDAGLCTHLSYSFFGINDNGEIQSLDTWLDYDLGFINQA 83
            |.::| ||:..||.||.|..:|...::|..|||||.|:|.|:. |.::.:.: |.|..|  ..:.
Human    21 AAKLV-CYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAGMT-NHQLSTTE-WNDETL--YQEF 80

  Fly    84 ISLKNQNSNLKVLAVVGGWNEGSTKYSSMSGDWYKRQNFINSALNLLRNHGFDGLDLDWEYPNQR 148
            ..||..|..||.|..:||||.|:.|::.|......||.|:|||:..||.:.|||||||||||..:
Human    81 NGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFVNSAIRFLRKYSFDGLDLDWEYPGSQ 145

  Fly   149 GGNWNDRANFVTLLREIKEAF----APYGYE---LGIAVGAGESLASASYEIANIAQQVDFINVM 206
            |....|:..|.||::::..||    ...|.|   |..||.||::...|.||:..|||.:||:|:|
Human   146 GSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLLSAAVPAGQTYVDAGYEVDKIAQNLDFVNLM 210

  Fly   207 TYDFAMASDGQTGFNAPQWA------------VENAINFWLSQGAPANKLVLGVGTYGRSFQLSD 259
            .|||..:.:..||.|:|.:.            |:.|:..||.:|.||:||:||:.||||||.|:.
Human   211 AYDFHGSWEKVTGHNSPLYKRQEESGAAASLNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLAS 275

  Fly   260 SSQNWPGAPCRGEGSAGSYTGSTGYLGYNEICQNNWHTVFD---YDNAAPYAYSGDQWVSFDNVL 321
            ||....|||..|.|:.|.:|...|.|.|.|:|  :|.....   .|...||.:..:|||.||:|.
Human   276 SSDTRVGAPATGSGTPGPFTKEGGMLAYYEVC--SWKGATKQRIQDQKVPYIFRDNQWVGFDDVE 338

  Fly   322 SVQYKMDFALSKGLAGAMIWSLETDDYRG-QCGE-TYPLLKTINRKL 366
            |.:.|:.:...|||.|||:|:|:.||:.| .|.: .|||::|:.::|
Human   339 SFKTKVSYLKQKGLGGAMVWALDLDDFAGFSCNQGRYPLIQTLRQEL 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht9	NP_611543.3	GH18_chitolectin_chitotriosidase	23..366	CDD:119351	145/366 (40%)
Cht9	NP_611543.3	Glyco_18	23..346	CDD:214753	137/344 (40%)
CHIT1	NP_003456.1	Glyco_18	23..363	CDD:214753	137/346 (40%)
		GH18_chitolectin_chitotriosidase	24..385	CDD:119351	145/367 (40%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	70..71		0/1 (0%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	97..100		2/2 (100%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	210..213		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..424
		ChtBD2	419..466	CDD:214696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156441
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2811
OMA	1	1.010	-	-		QHG58170
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.710