DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht8 and CTS2

DIOPT Version :9

Sequence 1:	NP_611542.2	Gene:	Cht8 / 37390	FlyBaseID:	FBgn0034580	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_010659.1	Gene:	CTS2 / 851977	SGDID:	S000002779	Length:	511	Species:	Saccharomyces cerevisiae

Alignment Length:	409	Identity:	112/409 - (27%)
Similarity:	188/409 - (45%)	Gaps:	89/409 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 YQGTWSVYRPGLGKFGM-EDIDPFLCTHLIYAFLGI-EETGQLRVIDAYLDLEENSGRG-NIKSF 95
            |...||.|:|   :|.. .||:....:|:.|||..| ..||.:...|::.|||.|..:. .||:.
Yeast    78 YYSNWSPYKP---RFHFPHDINLKQVSHIYYAFFKINSRTGGIENTDSWSDLEMNLYKSLAIKNS 139

  Fly    96 NALK---------------------LKNPV----LKTLVAVGGWNEGSKRFSLVARDPSKREKFV 135
            ..:|                     |||..    .|.::::|||:: |:.|.::.:|....:.||
Yeast   140 ELIKESSNNSVQNILPLGCIGELFYLKNTCSDKKFKVIMSIGGWSD-SENFKIIIKDDKLLQNFV 203

  Fly   136 DDVVRFLQRHGFDGLDLDWEYPGQRHSLDNEDRSNYITFLKELK---EGLEP--FG------FIL 189
            |..|..:.|.||||:|||||:||...|   |.| .|:..::.|:   ..||.  ||      |.|
Yeast   204 DSSVETMFRLGFDGIDLDWEFPGNNES---EPR-GYLKLVRMLRLKLNSLESQIFGKRTEDHFQL 264

  Fly   190 SAAVGSAQFSAEISY-DIPAMVPYLDLINVMAYDLHGPWDQVVGINAPLYAAEKDASDSSGRQQQ 253
            |  :.:..|..::.| .|..:..|:|..|:|.||.:|.|.:..|.::.|::           :.:
Yeast   265 S--IAAPAFKDKLFYLPITEIDQYVDYWNMMTYDYYGSWSETTGYHSNLFS-----------ETE 316

  Fly   254 LNVDAVVKYWL-KAGAPAEKLILGVPFYGRSFTLATAE-----GNQPGAPHIGKGIAGNYSRE-- 310
            ||.:..:.|.: :.|..:.||:||:..|||||.:...:     .|......|.||: |..::|
Yeast   317 LNGNFAMHYMIDRFGVNSRKLVLGMAAYGRSFHIKDNKFEPFNQNTVLINKIFKGV-GKPTKEID 380

  Fly   311 -----PGVLGYNELCEMMEREEWTQKWEATQQVPYAYRQRQ--WVGYEDPRSLALKAQYVMDNHL 368
                 .|:..|..|.::...|::..|:.:.    |.:.::.  ::.|::.:|:..||:||..|:|
Yeast   381 KADGKEGIWPYKNLPKIGTIEQYDPKYVSA----YCFDEKNSIFISYDNTKSVKTKAEYVTHNNL 441

  Fly   369 GGIMIWSLESDDFRGTCGQ 387
            ||...|.        :||:
Yeast   442 GGGFWWE--------SCGE 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht8	NP_611542.2	GH18_chitolectin_chitotriosidase	31..400	CDD:119351	112/409 (27%)
		Glyco_18	31..379	CDD:214753	110/399 (28%)
		CBM_14	424..476	CDD:279884
CTS2	NP_010659.1	ChiA	36..474	CDD:225862	112/409 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I1191
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	115	1.000	Inparanoid score	I1336
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	1	1.000	-	-		otm46727
orthoMCL	1	0.900	-	-		OOG6_100224
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2066
SonicParanoid	1	1.000	-	-		X91
TreeFam	0	0.000	Not matched by this tool.
	10	9.790