DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht8 and Cht7

DIOPT Version :9

Sequence 1:	NP_611542.2	Gene:	Cht8 / 37390	FlyBaseID:	FBgn0034580	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_647768.3	Gene:	Cht7 / 38370	FlyBaseID:	FBgn0035398	Length:	1013	Species:	Drosophila melanogaster

Alignment Length:	480	Identity:	178/480 - (37%)
Similarity:	263/480 - (54%)	Gaps:	39/480 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ILMAASSSAQGNSSKNVVCYQGTWSVYRPGLGKFGMEDIDPFLCTHLIYAFLGIEETGQLRVIDA 79
            |...|::.|.......|.||..:||..|||.|||..|:|||.||||::|||..:::   .::.:|
  Fly   544 IKSGANAVASNTRPAQVFCYLTSWSAKRPGAGKFQPENIDPKLCTHIVYAFATLQD---YKLTEA 605

  Fly    80 YLDLEENSGRGNIKSFNALKLKNPVLKTLVAVGGWNEGSKRFSLVARDPSKREKFVDDVVRFLQR 144
            ..|..|     |.:|..||:..||.|:.|:|:|||..||..|..:..:..:..:||.:.:.||:.
  Fly   606 TDDDPE-----NYESVIALRDNNPDLQILLAIGGWAFGSTPFKELTSNVFRMNQFVYEAIDFLRD 665

  Fly   145 HGFDGLDLDWEYPGQRHSLDNEDRSNYITFLKELKEGLEPFG-------FILSAAVGSAQFSAEI 202
            :.|:|||:|||||     ...|||..|::.||||:...|...       .:|:|||.::..:...
  Fly   666 YKFNGLDVDWEYP-----RGAEDRVAYVSLLKELRVAFEGEAKSSGLPRLLLTAAVPASFEAIAA 725

  Fly   203 SYDIPAMVPYLDLINVMAYDLHGPWDQVVGINAPLYAAEKDASDSSGRQQQLNVDAVVKYWLKAG 267
            .||:|.:..|||.||||.||.||.|::.||.|:||:|.|    .::|.|::|.||...:.|:|.|
  Fly   726 GYDVPEISKYLDFINVMTYDFHGQWERTVGHNSPLFALE----SATGYQKKLTVDYSAREWVKQG 786

  Fly   268 APAEKLILGVPFYGRSFTLATAEGNQPGAPHIGKGIAGNYSREPGVLGYNELCEMMEREEWTQKW 332
            ||.|||::|:|.|||||.|........|:|..|.|.||.::.|.|.|.|.|:|..:..:..|..|
  Fly   787 APKEKLLIGMPTYGRSFELVNDTQFDIGSPSSGGGKAGKFTNEAGFLSYYEVCSFLAADNTTLVW 851

  Fly   333 EATQQVPYAYRQRQWVGYEDPRSLALKAQYVMDNHLGGIMIWSLESDDFRGTCGQQPYPLLHEIN 397
            ::.||||:|||..||||::|.|||..|.:::.:...||||:||::.|||.|.||...||||..:|
  Fly   852 DSEQQVPFAYRGNQWVGFDDERSLKTKTEWLKEQGFGGIMVWSIDMDDFSGRCGSGKYPLLTALN 916

  Fly   398 RVL------------FGGNTPSGLTTESNRESPSEGFSCPADAPAGYIRDPDNCSKFYYCSGGKT 450
            ..|            :..:.|.|..|   .:.|.:......|....|.:|..:|:.:|.|.|.:.
  Fly   917 DELKDYKVELEYDGPYESHGPRGAYT---TKDPHDVTCAEEDGHISYHKDWADCTHYYMCEGERK 978

  Fly   451 HNFDCPSGLNFDLDTKSCNYSGSVK 475
            |:..||:.|.|:.....|::..:|:
  Fly   979 HHMPCPANLVFNPQENVCDWPENVE 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht8	NP_611542.2	GH18_chitolectin_chitotriosidase	31..400	CDD:119351	156/375 (42%)
		Glyco_18	31..379	CDD:214753	145/354 (41%)
		CBM_14	424..476	CDD:279884	14/52 (27%)
Cht7	NP_647768.3	Glyco_18	124..468	CDD:214753
		GH18_chitolectin_chitotriosidase	125..491	CDD:119351
		Glyco_18	559..898	CDD:214753	145/355 (41%)
		GH18_chitolectin_chitotriosidase	560..919	CDD:119351	156/375 (42%)
		CBM_14	951..1005	CDD:279884	14/53 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463828
Domainoid	1	1.000	188	1.000	Domainoid score	I962
eggNOG	1	0.900	-	-		E1_COG3325
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	1	1.000	-	-		mtm1002
orthoMCL	1	0.900	-	-		OOG6_100224
Panther	1	1.100	-	-	P	PTHR11177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2066
SonicParanoid	1	1.000	-	-		X91
	11	10.780