DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht8 and Cht10

DIOPT Version :9

Sequence 1:	NP_611542.2	Gene:	Cht8 / 37390	FlyBaseID:	FBgn0034580	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001036422.1	Gene:	Cht10 / 3355116	FlyBaseID:	FBgn0250907	Length:	2286	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	176/546 - (32%)
Similarity:	255/546 - (46%)	Gaps:	118/546 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SKNVVCYQGTWSVYRPGLGKFGMEDIDPFLCTHLIYAFLGIE-ETGQLRVIDAYLDLEENSGRGN 91
            :|.|:||...|:.||.|...|..|.|||.||:.:||:|..:: :...:|..|:::||:....|
  Fly   218 TKKVLCYMSNWAFYRSGEAHFVPEQIDPNLCSAIIYSFASLDPDHLTIREFDSWVDLDNQYYR-- 280

  Fly    92 IKSFNALKLKNPVLKTLVAVGGWNEGS-KRFSLVARDPSKREKFVDDVVRFLQRHGFDGLDLDWE 155
                ....|..||   |:|:|||.:.| .::|.:..|..||..|:..|..||.||||.||.|||.
  Fly   281 ----RVTSLGVPV---LIALGGWTDSSGSKYSRLVSDNLKRRVFISSVSSFLLRHGFSGLHLDWN 338

  Fly   156 YPGQRHSLDNE----DRSNYITFLKELK---EGLEPFGFILSAAVGSAQFSAEISYDIPAMVPYL 213
            ||....|..:.    ||.|....|:||:   :.::| .|.|..|:...:...:.:||.||:...:
  Fly   339 YPKCWQSDCSRGPVTDRPNLTKLLRELRTEFQSVDP-KFQLGVAISGYKEIIKEAYDFPALSDIV 402

  Fly   214 DLINVMAYDLHGPWDQVVGINAPLYAAEKDASDSSGRQQQLNVDAVVKYWLKAGAPAEKLILGVP 278
            |.:.||.||.||.|:|..|..:|||..      ||....|.|.:..::..||.||..|||:|.:|
  Fly   403 DYMTVMTYDYHGAWEQKTGHVSPLYGL------SSDTYPQYNTNYTMQLLLKMGARREKLVLSIP 461

  Fly   279 FYGRSFTLATAEGNQ----PGAPHIGKGIAGNYSREPGVLGYNELCEMMEREEWTQKWEATQQV- 338
            |||:|||||||  :|    ||....|.|.||..:::||:|.|.|:|:.:.:..|..  :....|
  Fly   462 FYGQSFTLATA--HQILAGPGVAASGPGDAGELTKQPGMLAYYEICQRLTKFNWIS--DRNLNVI 522

  Fly   339 --PYAYRQRQWVGYEDPRSLALKAQYVMDNHLGGIMIWSLESDDFRGTCGQQPYPLLHEINRVL- 400
              |:|....||||||||.|...||:|..:|:..|:..|:::.||||..|..:.||||..|||.|
  Fly   523 FGPFAMLNDQWVGYEDPTSAQAKARYAANNNFAGVAAWTIDLDDFRNLCCNESYPLLRAINRALG 587

  Fly   401 ---------------------------------FGG---------NTPSG--------------- 408
                                             .||         :.|||
  Fly   588 RLDSEPPTQPNCKRPTLLATPVPPQMTTISSDGSGGLGQNHDHTTSLPSGQISSSPVSTTITSTF 652

  Fly   409 ----LTTESNRESPSEGFSCPADA----PAG--------------YIRDPDNCSKFYYC-SGGKT 450
                .||:..|| |::..:.|...    |||              :..|.:||:.:|:| ..|:.
  Fly   653 PWWSSTTKRPRE-PTKTTAQPTHTTILIPAGINPVVQPSNCKSGEFFADSNNCNAYYHCFFAGEL 716

  Fly   451 HNFDCPSGLNFDLDTKSCNYSGSVKC 476
            ....|||||:::.:.|.|::..|.:|
  Fly   717 QQQFCPSGLHWNNEAKGCDWPSSAQC 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht8	NP_611542.2	GH18_chitolectin_chitotriosidase	31..400	CDD:119351	145/384 (38%)
		Glyco_18	31..379	CDD:214753	133/363 (37%)
		CBM_14	424..476	CDD:279884	18/70 (26%)
Cht10	NP_001036422.1	Glyco_18	220..565	CDD:214753	133/364 (37%)
		GH18_chitolectin_chitotriosidase	221..586	CDD:119351	145/384 (38%)
		ChtBD2	697..737	CDD:214696	13/39 (33%)
		CBM_14	801..848	CDD:279884
		CBM_14	875..918	CDD:279884
		Glyco_18	966..1310	CDD:214753
		GH18_chitolectin_chitotriosidase	967..1331	CDD:119351
		Glyco_18	1410..1753	CDD:214753
		GH18_chitolectin_chitotriosidase	1411..1774	CDD:119351
		ChtBD2	1834..1871	CDD:214696
		Glyco_18	1909..2253	CDD:214753
		GH18_chitolectin_chitotriosidase	1910..2274	CDD:119351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463774
Domainoid	1	1.000	188	1.000	Domainoid score	I962
eggNOG	1	0.900	-	-		E1_COG3325
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1002
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850