DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht8 and chia.6

DIOPT Version :9

Sequence 1:	NP_611542.2	Gene:	Cht8 / 37390	FlyBaseID:	FBgn0034580	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_955897.2	Gene:	chia.6 / 322420	ZFINID:	ZDB-GENE-030131-1140	Length:	480	Species:	Danio rerio

Alignment Length:	475	Identity:	175/475 - (36%)
Similarity:	244/475 - (51%)	Gaps:	48/475 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SKNVVCYQGTWSVYRPGLGKFGMEDIDPFLCTHLIYAFLGIEETGQLRVIDAYLDLEENSGRGNI 92
            :..:|||...||.|||.:||:...::||.|||||||||..|....:|...       |.:.....
Zfish    20 ASQLVCYFTNWSQYRPDVGKYMPSNVDPHLCTHLIYAFSIINNENKLTTY-------EWNDETLY 77

  Fly    93 KSFNALKLKNPVLKTLVAVGGWNEGSKRFSLVARDPSKREKFVDDVVRFLQRHGFDGLDLDWEYP 157
            :|||.||..||.||||:||||||.|:.:||.:...|..|:.|:...:.||:.|||||||||||||
Zfish    78 QSFNGLKQSNPNLKTLLAVGGWNFGTTQFSSMVSTPQNRQTFIQSSITFLRTHGFDGLDLDWEYP 142

  Fly   158 GQRHSLDNEDRSNYITFLKELKEGLEPFG-------FILSAAVGSAQFSAEISYDIPAMVPYLDL 215
            |.|.| ..||:..:....|||.|..:...       .:|:|||.:.:.:.:..|:|..:..|||.
Zfish   143 GSRGS-PPEDKQRFTLLCKELVEAYQAESAATGRPRLMLTAAVAAGKGNIDAGYEIAEIAKYLDF 206

  Fly   216 INVMAYDLHGPWDQVVGINAPLYAAEKDASDSSGRQQQLNVDAVVKYWLKAGAPAEKLILGVPFY 280
            ||:|.||.||.|:.|.|.|:|||....|..|    :...|.|..:.||...|||.|||.:|...|
Zfish   207 INIMTYDFHGSWESVTGHNSPLYRGSGDIGD----KIYYNTDFAMTYWRDQGAPVEKLRMGFAAY 267

  Fly   281 GRSFTLATAEGNQPGAPHIGKGIAGNYSREPGVLGYNELCEMMEREEWTQKWEATQQVPYAYRQR 345
            ||:|.|::|... .|||..|...||.|:||.|...|.|:|..:::.  |.:....|:||||.:.:
Zfish   268 GRTFRLSSAVSG-VGAPASGAASAGTYTREAGFWSYYEICTFLKQA--TVQQIVDQKVPYATKGQ 329

  Fly   346 QWVGYEDPRSLALKAQYVMDNHLGGIMIWSLESDDFRGT-CGQQPYPLLHEINRVLFGGNT---- 405
            :|||:::..|...|..|:.:...||..:|:|:.|||.|. |||..|||:.::..:|...||
Zfish   330 EWVGFDNMESYKTKVDYLKEKGFGGAFVWALDLDDFSGQFCGQSKYPLIGQLRTLLNINNTEFPY 394

  Fly   406 --------PSGLTTESNR------------ESPSEGFSCPADAPAGYIRDPDNCSKFYYCSGGKT 450
                    |||..|.::.            .:||....|.... .|....|.:...:.:|:.|:|
Zfish   395 NPPSTTVKPSGRPTRASATVPYATRPPVVPTAPSGSDFCTGKL-EGIYEYPADSMIYIHCANGRT 458

  Fly   451 HNFDCPSGLNFDLDTKSCNY 470
            ....||:...||.|.|.||:
Zfish   459 FIQRCPAKTVFDPDCKCCNW 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht8	NP_611542.2	GH18_chitolectin_chitotriosidase	31..400	CDD:119351	152/376 (40%)
		Glyco_18	31..379	CDD:214753	142/354 (40%)
		CBM_14	424..476	CDD:279884	14/47 (30%)
chia.6	NP_955897.2	Glyco_18	22..363	CDD:214753	142/355 (40%)
		GH18_chitolectin_chitotriosidase	23..385	CDD:119351	152/376 (40%)
		CBM_14	433..479	CDD:279884	14/47 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2545
OMA	1	1.010	-	-		QHG58170
OrthoDB	1	1.010	-	-		D1289629at2759
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100224
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2066
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.810