DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht8 and Chit1

DIOPT Version :9

Sequence 1:	NP_611542.2	Gene:	Cht8 / 37390	FlyBaseID:	FBgn0034580	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001073157.1	Gene:	Chit1 / 289032	RGDID:	1305646	Length:	464	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	179/493 - (36%)
Similarity:	260/493 - (52%)	Gaps:	60/493 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SVSGLVKLLLGVILMAASSSAQGNSSKNVVCYQGTWSVYRPGLGKFGMEDIDPFLCTHLIYAFLG 67
            :::|:..||:          .|..|:..:.||...|:.||.|..:|...|:||.||||:||||.|
  Rat     6 ALAGVTTLLM----------IQWGSAAKLFCYFTNWAQYRSGAARFLPRDVDPNLCTHVIYAFAG 60

  Fly    68 IEETGQLRVIDAYLDLEENSGRGNIKSFNALKLKNPVLKTLVAVGGWNEGSKRFSLVARDPSKRE 132
            : ...|:..::...:|       ..:..|:||.:||.||||:|||||:.|:::|:.:....|.|:
  Rat    61 L-NNHQVSTVEPNDEL-------FYQELNSLKKRNPKLKTLLAVGGWSFGTQKFTDMVATASTRQ 117

  Fly   133 KFVDDVVRFLQRHGFDGLDLDWEYPGQRHSLDNEDRSNYITFLKELKEGLEPFG-------FILS 190
            .||:..:.||:.||||||||||||||.|.| ...|:..:...:::|.:..:...       .:|:
  Rat   118 TFVNSALSFLRTHGFDGLDLDWEYPGSRGS-PAVDKERFTALIQDLAKAFQEEARASGKSRLLLT 181

  Fly   191 AAVGSAQFSAEISYDIPAMVPYLDLINVMAYDLHGPWDQVVGINAPLYAAEKDASDSSGRQQQLN 255
            |||.:.:...:..|::..:|..||.||:||||.|..||:..|.|:|||..:.:    :|:..:.|
  Rat   182 AAVPTGRGHVDAGYEVDKIVQSLDFINLMAYDFHSSWDKTTGHNSPLYKRQGE----TGKDAEKN 242

  Fly   256 VDAVVKYWLKAGAPAEKLILGVPFYGRSFTLATAEGNQPGAPHIGKGIAGNYSREPGVLGYNELC 320
            |||.|..||:.|.||.||:||:|.||||||||::..:..|||..|.|..|.|::|.|:|.|.|:|
  Rat   243 VDAAVTLWLQKGTPASKLMLGMPAYGRSFTLASSSDSGVGAPATGPGAPGPYTKEKGILVYFEVC 307

  Fly   321 EMMEREEWTQKWE-ATQQVPYAYRQRQWVGYEDPRSLALKAQYVMDNHLGGIMIWSLESDDFRGT 384
                  .|..|.. ..|:|||..:..||||::|..|...||.||....|||.|:|.|:.|||:|:
  Rat   308 ------SWKGKQRIEDQKVPYVSQGNQWVGFDDRESFRAKAAYVKQKGLGGAMVWILDGDDFKGS 366

  Fly   385 -CGQQPYPLLHEINRVLF--------------GGNTPSGLTTESNRESPSEGFS--CPADAPAGY 432
             |.:..|||:..:::.|.              |.:.||     ...:.||.|..  |...|. |.
  Rat   367 FCNEGQYPLIRTLHQELSLSSGPPRSPEQEVPGPHQPS-----EPEQGPSPGLDDFCQGKAD-GL 425

  Fly   433 IRDPDNCSKFYYCSGGKTHNFDCPSGLNFDLDTKSCNY 470
            ..:|...|.||.|.||:.....||.||.|....|.|.:
  Rat   426 YPNPTEKSSFYSCGGGRLFQHSCPPGLVFIDSCKCCTW 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht8	NP_611542.2	GH18_chitolectin_chitotriosidase	31..400	CDD:119351	150/377 (40%)
		Glyco_18	31..379	CDD:214753	142/355 (40%)
		CBM_14	424..476	CDD:279884	17/47 (36%)
Chit1	NP_001073157.1	GH18_chitolectin_chitotriosidase	24..383	CDD:119351	150/377 (40%)
Chit1	NP_001073157.1	ChtBD2	416..463	CDD:214696	17/47 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350389
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2302
OMA	1	1.010	-	-		QHG58170
OrthoDB	1	1.010	-	-		D1289629at2759
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100224
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.810