Protein Alignment Cht8 and CHIA

DIOPT Version :10

• Sequence 1: NP_611542.2
• Gene: Cht8 / 37390
• FlyBaseID: FBgn0034580
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_970615.2
• Gene: CHIA / 27159
• HGNCID: 17432
• Length: 476
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 187/496 - (37%)
• Similarity: 271/496 - (54%)
• Gaps: 59/496 - (11%)

  Fly    10 LLLGVILMAASSSAQGNSSKNVVCYQGTWSVYRPGLGKFGMEDIDPFLCTHLIYAFLGIEETGQL 74
            ||.|::|:.   :.|..|:..:.||...|:.||||||:|..::|||.|||||||||.| .:..::
Human     6 LLTGLVLIL---NLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG-RQNNEI 66

  Fly    75 RVI---DAYLDLEENSGRGNIKSFNALKLKNPVLKTLVAVGGWNEGSKRFSLVARDPSKREKFVD 136
            ..|   |..|          .::||.||.||..||||:|:||||.|:..|:.:...|..|:.|:.
Human    67 TTIEWNDVTL----------YQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFIT 121

  Fly   137 DVVRFLQRHGFDGLDLDWEYPGQRHSLDNEDRSNYITFLKELKEGLEPFG-------FILSAAVG 194
            .|::||:::.|||||.||||||.|.| ..:|:..:...::|::|..|...       .:::|||.
Human   122 SVIKFLRQYEFDGLDFDWEYPGSRGS-PPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVA 185

  Fly   195 SAQFSAEISYDIPAMVPYLDLINVMAYDLHGPWDQVVGINAPLYAAEKDASDSSGRQQQLNVDAV 259
            :...:.:..|:||.:..|||.|:||.|||||.|:...|.|:|||....|    :|....||||.|
Human   186 AGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTD----TGSNAYLNVDYV 246

  Fly   260 VKYWLKAGAPAEKLILGVPFYGRSFTLATAEGNQPGAPHIGKGIAGNYSREPGVLGYNELCEMME 324
            :.||...||||||||:|.|.||.:|.|:.......|||..|.|.||.|::|.|:..|.|:|..::
Human   247 MNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLK 311

  Fly   325 REEWTQKWEATQQVPYAYRQRQWVGYEDPRSLALKAQYVMDNHLGGIMIWSLESDDFRGT-CGQQ 388
            ... ||.|:|.|:|||||:...||||::.:|..:|||::..|..||.|:|:::.|||.|| |.|.
Human   312 NGA-TQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQG 375

  Fly   389 PYPLLHEINRVL---------------------FGGNTPSGLTTESNRESPSEGFSCPADAPAGY 432
            .:||:..:.:.|                     .|....|| ::.|...|...|| |...|...|
Human   376 KFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSG-SSSSGGSSGGSGF-CAVRANGLY 438

  Fly   433 IRDP--DNCSKFYYCSGGKTHNFDCPSGLNFDLDTKSCNYS 471
               |  :|.:.|::|..|.|:..:|.:||.||.....||::
Human   439 ---PVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cht8	NP_611542.2	GH18_chitolectin_chitotriosidase	31..400	CDD:119351	157/379 (41%)
		CBM_14	424..476	CDD:426342	16/50 (32%)
CHIA	NP_970615.2	GH18_chitolectin_chitotriosidase	24..387	CDD:119351	157/379 (41%)
		ChtBD2	429..476	CDD:214696	17/50 (34%)