back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht8 and CHIA

DIOPT Version :9

Sequence 1:	NP_611542.2	Gene:	Cht8 / 37390	FlyBaseID:	FBgn0034580	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_970615.2	Gene:	CHIA / 27159	HGNCID:	17432	Length:	476	Species:	Homo sapiens

Alignment Length:	496	Identity:	187/496 - (37%)
Similarity:	271/496 - (54%)	Gaps:	59/496 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLGVILMAASSSAQGNSSKNVVCYQGTWSVYRPGLGKFGMEDIDPFLCTHLIYAFLGIEETGQL 74
            ||.|::|:.   :.|..|:..:.||...|:.||||||:|..::|||.|||||||||.| .:..::
Human     6 LLTGLVLIL---NLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG-RQNNEI 66

  Fly    75 RVI---DAYLDLEENSGRGNIKSFNALKLKNPVLKTLVAVGGWNEGSKRFSLVARDPSKREKFVD 136
            ..|   |..|          .::||.||.||..||||:|:||||.|:..|:.:...|..|:.|:.
Human    67 TTIEWNDVTL----------YQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFIT 121

  Fly   137 DVVRFLQRHGFDGLDLDWEYPGQRHSLDNEDRSNYITFLKELKEGLEPFG-------FILSAAVG 194
            .|::||:::.|||||.||||||.|.| ..:|:..:...::|::|..|...       .:::|||.
Human   122 SVIKFLRQYEFDGLDFDWEYPGSRGS-PPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVA 185

  Fly   195 SAQFSAEISYDIPAMVPYLDLINVMAYDLHGPWDQVVGINAPLYAAEKDASDSSGRQQQLNVDAV 259
            :...:.:..|:||.:..|||.|:||.|||||.|:...|.|:|||....|    :|....||||.|
Human   186 AGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTD----TGSNAYLNVDYV 246

  Fly   260 VKYWLKAGAPAEKLILGVPFYGRSFTLATAEGNQPGAPHIGKGIAGNYSREPGVLGYNELCEMME 324
            :.||...||||||||:|.|.||.:|.|:.......|||..|.|.||.|::|.|:..|.|:|..::
Human   247 MNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLK 311

  Fly   325 REEWTQKWEATQQVPYAYRQRQWVGYEDPRSLALKAQYVMDNHLGGIMIWSLESDDFRGT-CGQQ 388
            ... ||.|:|.|:|||||:...||||::.:|..:|||::..|..||.|:|:::.|||.|| |.|.
Human   312 NGA-TQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQG 375

  Fly   389 PYPLLHEINRVL---------------------FGGNTPSGLTTESNRESPSEGFSCPADAPAGY 432
            .:||:..:.:.|                     .|....|| ::.|...|...|| |...|...|
Human   376 KFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSG-SSSSGGSSGGSGF-CAVRANGLY 438

  Fly   433 IRDP--DNCSKFYYCSGGKTHNFDCPSGLNFDLDTKSCNYS 471
               |  :|.:.|::|..|.|:..:|.:||.||.....||::
Human   439 ---PVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA 476

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.