DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht8 and cht-2

DIOPT Version :9

Sequence 1:	NP_611542.2	Gene:	Cht8 / 37390	FlyBaseID:	FBgn0034580	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_495798.2	Gene:	cht-2 / 174363	WormBaseID:	WBGene00011757	Length:	626	Species:	Caenorhabditis elegans

Alignment Length:	529	Identity:	138/529 - (26%)
Similarity:	232/529 - (43%)	Gaps:	128/529 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWSVSGLVKLLLGVILMAASSSAQGNSSKNVVCYQGTWSVYRPGLGKFGMEDIDPFLCTHLIYAF 65
            ||.....:.:|.||   :.......:..:..|.|..:|       ||....|......|||::||
Worm     7 MWLFVVWITVLFGV---SNGGILDRSCGRRRVGYITSW-------GKHPFRDDQAEKLTHLVFAF 61

  Fly    66 LGIEETGQLRVIDAYLDLEENSGRGNIKSFNALKLKNPVLKTLVAVGGWNEGSKRFSLVARDPSK 130
            ..::..|.::       ||.::.:..::....:..::|.||.|.||||| |.|:.||::..|.|:
Worm    62 FVVDSDGSVK-------LEGDAAKARLEHVKEVASRHPDLKLLYAVGGW-ENSQYFSVLTADHSR 118

  Fly   131 REKFVDDVVRFLQRHGFDGLDLDWEYPGQRHSLDN--EDRSNYITFLKELKEGLEPF------GF 187
            |...:.:.|:.::.:||||:|:|||||....:::.  .||.||:..::||:..|...      .:
Worm   119 RSILISNFVKVIKEYGFDGVDIDWEYPVTGGAVEGTPADRRNYVNLMRELRNELRDLESETGKSY 183

  Fly   188 ILSAAVGSAQFSAEISYDIPAMVPYLDLINVMAYDLHG----PWDQVVGINAPL-YAAEKDASDS 247
            ::|.|..:..:..:..||:..::.|.|.:|||:||..|    .|....|..||| :|..|   ..
Worm   184 LISFAGAAGHWVLKPGYDLQQLMKYCDFVNVMSYDYFGAWASKWGAYTGPPAPLQFAMPK---KF 245

  Fly   248 SGRQQQLNVDAVVKYW---LKAGAPAEKLILGVPFYG-----------------RSFTLATAEGN 292
            |||   :||.|.:|.:   :||   .:|:.:||||||                 |:.|...:||.
Worm   246 SGR---MNVHATMKDYSCQIKA---TDKINMGVPFYGRFWKNVGDAVDSTDDMWRTATATNSEGT 304

  Fly   293 QPGAPHIGKGIAGNYSREPGVLGYNELCEMMEREEWTQKWEATQQVPYAY--RQRQWVGYEDPRS 355
            :               .|.|.:.:.:|.|..:..:  .|:.:..:.|:.:  .|:.:||||:..|
Worm   305 K---------------FEGGDVQWRDLHEKFDTTK--TKFHSGSKTPFIWLSEQKTFVGYENAES 352

  Fly   356 LALKAQYVMDNHLGGIMIWSLESDDFRGTCGQQPYPLLHEINRVLFGGNTPSGLTTESNRESPSE 420
            |..|..|:::|::||:|||:::.||.:||               |........:.|.|.:   |.
Worm   353 LKHKVDYIVENNIGGVMIWAIDFDDDQGT---------------LLNSAAAESICTTSTK---SF 399

  Fly   421 GFSC-PAD--------------------APA--GY--IRDPDN-----CSKFYYCSGGKTHNFDC 455
            .:.| |.|                    :|.  ||  :.|||:     |.|:.||..| .....|
Worm   400 NYKCSPVDDKRWWTYDDNEELAGMCGKSSPLIDGYYPVCDPDDPGHACCGKYGYCGSG-AEFCSC 463

  Fly   456 PSGLNFDLD 464
            |..:::..|
Worm   464 PECIDYGAD 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht8	NP_611542.2	GH18_chitolectin_chitotriosidase	31..400	CDD:119351	112/403 (28%)
		Glyco_18	31..379	CDD:214753	108/382 (28%)
		CBM_14	424..476	CDD:279884	17/71 (24%)
cht-2	NP_495798.2	Glyco_18	33..376	CDD:214753	108/383 (28%)
		GH18_chitinase-like	35..376	CDD:299167	108/381 (28%)
		ChtBD1_GH18_2	418..469	CDD:211315	13/51 (25%)
		ChtBD1_GH18_2	496..547	CDD:211315
		ChtBD1_GH18_2	567..618	CDD:211315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1289629at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4747
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820