back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht8 and CHI3L2

DIOPT Version :9

Sequence 1:	NP_611542.2	Gene:	Cht8 / 37390	FlyBaseID:	FBgn0034580	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_003991.2	Gene:	CHI3L2 / 1117	HGNCID:	1933	Length:	390	Species:	Homo sapiens

Alignment Length:	412	Identity:	158/412 - (38%)
Similarity:	234/412 - (56%)	Gaps:	47/412 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWSVSGLVKLLLGVILMAASSSAQGNSSKNVVCYQGTWSVYRPGLGKFGMEDIDPFLCTHLIYAF 65
            :|  :|:|.|||          .||.|:..:|||...||..|...|||..|:||||||:||||:|
Human    11 LW--AGVVVLLL----------LQGGSAYKLVCYFTNWSQDRQEPGKFTPENIDPFLCSHLIYSF 63

  Fly    66 LGIEETGQLRVIDAYLDLEENSGRGNIKSFNALKLKNPVLKTLVAVGGWNEGSKRFSLVARDPSK 130
            ..||..   :||     :::.|.....::.|:||.|||.||.|:::||:..|||.|..:....:.
Human    64 ASIENN---KVI-----IKDKSEVMLYQTINSLKTKNPKLKILLSIGGYLFGSKGFHPMVDSSTS 120

  Fly   131 REKFVDDVVRFLQRHGFDGLDLDWEYPGQR---------HSLDNEDRSNYITFLKELKEGLEPFG 186
            |.:|::.::.||:.|.|||||:.|.||.|:         |.|....:.:   |.|..||.|
Human   121 RLEFINSIILFLRNHNFDGLDVSWIYPDQKENTHFTVLIHELAEAFQKD---FTKSTKERL---- 178

  Fly   187 FILSAAVGSAQFSAEISYDIPAMVPYLDLINVMAYDLHGPWDQ--VVGINAPLYAAEKDASDSSG 249
             :|:|.|.:.:...:.||.:..:...||.||::::|.||.|::  :.|.|:||....:|...||
Human   179 -LLTAGVSAGRQMIDNSYQVEKLAKDLDFINLLSFDFHGSWEKPLITGHNSPLSKGWQDRGPSS- 241

  Fly   250 RQQQLNVDAVVKYWLKAGAPAEKLILGVPFYGRSFTLATAEGNQPGAPHIGKGIAGNYSREPGVL 314
               ..||:..|.||:..|.|:||:::|:|.||.|||||:|| ...|||..|.|.||..:...|.|
Human   242 ---YYNVEYAVGYWIHKGMPSEKVVMGIPTYGHSFTLASAE-TTVGAPASGPGAAGPITESSGFL 302

  Fly   315 GYNELCEMMEREEWTQKWEATQQVPYAYRQRQWVGYEDPRSLALKAQYVMDNHLGGIMIWSLESD 379
            .|.|:|:.::..:.|:..:  ||||||.:..|||||:|.:|:..|.|::.:.:|||.||||::.|
Human   303 AYYEICQFLKGAKITRLQD--QQVPYAVKGNQWVGYDDVKSMETKVQFLKNLNLGGAMIWSIDMD 365

  Fly   380 DFRG-TCGQQPYPLLHEINRVL 400
            ||.| :|.|.||||:..:.|.|
Human   366 DFTGKSCNQGPYPLVQAVKRSL 387

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.