DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA4 and Shawl

DIOPT Version :10

Sequence 1:NP_002224.1 Gene:KCNA4 / 3739 HGNCID:6222 Length:653 Species:Homo sapiens
Sequence 2:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster


Alignment Length:529 Identity:177/529 - (33%)
Similarity:247/529 - (46%) Gaps:155/529 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   177 RVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 241
            |:::||||:|:||...||.:.|.|.|....:....:||:.|||||||:...|..||.||:: |:|
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69

Human   242 KRPVNVPFDIFTEEVKFYQLGEE--------------------ALLKFREDEGFVREEE------ 280
            ..|.:|...:|.||::|:.|...                    |:|...:.|.....||      
  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134

Human   281 --DRALPENE------FKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRD 337
              :.||...|      .|.:||.:|:.|.||:.|:.:|.:||..|.:|::.|||:|.|.||.|  
  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVD-- 197

Human   338 LVMALSAGGH------------------------------------------------------- 347
                |.:|.|                                                       
  Fly   198 ----LPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNF 258

Human   348 -------------------------GGLLNDTSAPHLENS--GHT---------IFNDP---FFI 373
                                     |.:||:    .:|..  ||.         .:..|   ||.
  Fly   259 TASGQATPIATIKGGQRQRLKRNINGSILNE----FIEEKILGHNGRRKHGWIETYGQPHEAFFY 319

Human   374 VETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAM 438
            ||.||.|||..|.::|....|:...|.|:.:||||..:.|.::    ||:.|:.|...|      
  Fly   320 VELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY----TDVMQRMGEYTG------ 374

Human   439 SFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAE--A 501
               :|....:||:.|:|||:|||.||:||.||.:||.:||.||:|||.:|::.|:|..|:||  .
  Fly   375 ---LLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQ 436

Human   502 DEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF 566
            |.|...|:|||...|||:||||||||||:.|.|..|..||:|||:|||||||||||||||||:.|
  Fly   437 DNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMF 501

Human   567 Y-HRETENE 574
            | |.:..::
  Fly   502 YSHTQARSK 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA4NP_002224.1 K_channel_TID 1..>37 CDD:429748
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..148
BTB_POZ 176..303 CDD:453885 49/159 (31%)
Ion_trans 306..570 CDD:459842 126/360 (35%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 462..475 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 524..529 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..653
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P15385 651..653
ShawlNP_001097131.2 BTB_Shaw-like 4..115 CDD:349723 37/109 (34%)
Ion_trans 307..506 CDD:459842 103/211 (49%)
Blue background indicates that the domain is not in the aligned region.

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