DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA4 and Shab

DIOPT Version :9

Sequence 1:NP_002224.1 Gene:KCNA4 / 3739 HGNCID:6222 Length:653 Species:Homo sapiens
Sequence 2:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster


Alignment Length:598 Identity:186/598 - (31%)
Similarity:281/598 - (46%) Gaps:125/598 - (20%)


- Green bases have known domain annotations that are detailed below.


Human     7 SAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGS-GGSGGGSHHHHQSRGA 70
            |...:|..:....|..:.|..:|........|:...::...:..:.|| ||.|.|........|.
  Fly   203 SGAGTGTGTGAGSGSGSGAAGKEVRYAPFPVASPTHSIPTTSQQIVGSVGGVGVGGASSQSISGG 267

Human    71 CTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEE 135
            ..:|...::.|:.:|...||        .||.|.....|.:.|:                     
  Fly   268 VPTHSQSNTTGALQRTHSRS--------MSSIPPPEPFMIAQSK--------------------- 303

Human   136 EEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPET 200
                                            :|.     .||.|||.|:|.|...:||.:.|.|
  Fly   304 --------------------------------AVN-----SRVSINVGGVRHEVLWRTLERLPHT 331

Human   201 LLGDPEKRTQY---------FDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEV 256
            .||...:.|.:         :....|||||||:..||.:||.:|:: |:|.....:....|::::
  Fly   332 RLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRT-GKLHIVDEMCVLAFSDDL 395

Human   257 ----------------KFYQLGEEALLKFREDEGFVREEEDRALPEN---EFKKQIWLLFEYPES 302
                            |::|..|....:.|::...:|:.::....|.   |::|.:|.|.|.|.:
  Fly   396 EYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNT 460

Human   303 SSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIF 367
            |..||.||::|:|.|::|.:...|.|||:.:                        |::| |....
  Fly   461 SFAARVIAVISILFIVLSTIALTLNTLPQLQ------------------------HIDN-GTPQD 500

Human   368 NDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNG 432
            |....:||.|||.||:.|:::|..|.|.:..|||..:||||:::|||||::|  .|.:.......
  Fly   501 NPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSL--FLLETNKNATD 563

Human   433 QQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVY 497
            |.|...  .::::.|::|:.||.||:|||.|||.||.|||.|.:|||||:.||.:||::|||..|
  Fly   564 QFQDVR--RVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAY 626

Human   498 FAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSN 562
            |||.||..|.|.|||:.||||.:|||||||||:.|.|..||::|::|.|.|||.||||:|:||:|
  Fly   627 FAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNN 691

Human   563 FNYFYHRETENEE 575
            |..||..:...|:
  Fly   692 FAEFYKNQMRREK 704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA4NP_002224.1 K_channel_TID 1..>37 CDD:400339 5/29 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..148 20/124 (16%)
BTB_POZ 176..303 CDD:365784 42/154 (27%)
Ion_trans 306..570 CDD:395416 118/263 (45%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 462..475 8/12 (67%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 524..529 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..653
PDZ-binding. /evidence=ECO:0000250 651..653
ShabNP_001189037.1 BTB 309..416 CDD:197585 30/107 (28%)
BTB_2 309..408 CDD:280393 29/99 (29%)
Ion_trans 501..700 CDD:278921 103/202 (51%)
Ion_trans_2 613..696 CDD:285168 50/82 (61%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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