DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KCNA4 and Shab

DIOPT Version :10

Sequence 1:NP_002224.1 Gene:KCNA4 / 3739 HGNCID:6222 Length:653 Species:Homo sapiens
Sequence 2:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster


Alignment Length:598 Identity:186/598 - (31%)
Similarity:281/598 - (46%) Gaps:125/598 - (20%)


- Green bases have known domain annotations that are detailed below.


Human     7 SAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGS-GGSGGGSHHHHQSRGA 70
            |...:|..:....|..:.|..:|........|:...::...:..:.|| ||.|.|........|.
  Fly   203 SGAGTGTGTGAGSGSGSGAAGKEVRYAPFPVASPTHSIPTTSQQIVGSVGGVGVGGASSQSISGG 267

Human    71 CTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEE 135
            ..:|...::.|:.:|...||        .||.|.....|.:.|:                     
  Fly   268 VPTHSQSNTTGALQRTHSRS--------MSSIPPPEPFMIAQSK--------------------- 303

Human   136 EEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPET 200
                                            :|.     .||.|||.|:|.|...:||.:.|.|
  Fly   304 --------------------------------AVN-----SRVSINVGGVRHEVLWRTLERLPHT 331

Human   201 LLGDPEKRTQY---------FDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEV 256
            .||...:.|.:         :....|||||||:..||.:||.:|:: |:|.....:....|::::
  Fly   332 RLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRT-GKLHIVDEMCVLAFSDDL 395

Human   257 ----------------KFYQLGEEALLKFREDEGFVREEEDRALPEN---EFKKQIWLLFEYPES 302
                            |::|..|....:.|::...:|:.::....|.   |::|.:|.|.|.|.:
  Fly   396 EYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNT 460

Human   303 SSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIF 367
            |..||.||::|:|.|::|.:...|.|||:.:                        |::| |....
  Fly   461 SFAARVIAVISILFIVLSTIALTLNTLPQLQ------------------------HIDN-GTPQD 500

Human   368 NDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNG 432
            |....:||.|||.||:.|:::|..|.|.:..|||..:||||:::|||||::|  .|.:.......
  Fly   501 NPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSL--FLLETNKNATD 563

Human   433 QQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVY 497
            |.|...  .::::.|::|:.||.||:|||.|||.||.|||.|.:|||||:.||.:||::|||..|
  Fly   564 QFQDVR--RVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAY 626

Human   498 FAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSN 562
            |||.||..|.|.|||:.||||.:|||||||||:.|.|..||::|::|.|.|||.||||:|:||:|
  Fly   627 FAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNN 691

Human   563 FNYFYHRETENEE 575
            |..||..:...|:
  Fly   692 FAEFYKNQMRREK 704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA4NP_002224.1 K_channel_TID 1..>37 CDD:429748 5/29 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..148 20/124 (16%)
BTB_POZ 176..303 CDD:453885 42/154 (27%)
Ion_trans 306..570 CDD:459842 118/263 (45%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 462..475 8/12 (67%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 524..529 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..653
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P15385 651..653
ShabNP_001189037.1 BTB_POZ_Shab-like 306..414 CDD:349720 31/113 (27%)
Ion_trans 464..700 CDD:459842 118/264 (45%)
Blue background indicates that the domain is not in the aligned region.

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