Protein Alignment KCNA4 and KCNQ

DIOPT Version :10

• Sequence 1: NP_002224.1
• Gene: KCNA4 / 3739
• HGNCID: 6222
• Length: 653
• Species: Homo sapiens
• Sequence 2: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Alignment Length: 397
• Identity: 95/397 - (23%)
• Similarity: 158/397 - (39%)
• Gaps: 103/397 - (25%)

Human   213 DPLRNEY-FFD---------RNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALL 267
            ||..:.| |:|         ..||:.:.||....|  .|.:|:|            |..|....:
  Fly     2 DPDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMS--LLGKPLN------------YNRGTRRDV 52

Human   268 KFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCL-----E 327
            ::|                 ..:.:::...|.|      ||:..:...|::..:|..||     .
  Fly    53 RYR-----------------RLQSRLYNFLERP------RGLHAIFYHVMVFLMVFTCLALSVFS 94

Human   328 TLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFA 392
            |:.|:.:|...::                               |.:|.:.::||:.||..|.::
  Fly    95 TIKEYEEDAVYIL-------------------------------FRMEILVVIWFTMEFGARLWS 128

Human   393 ---------CPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRL 448
                     |..:..|.|....|||||:||...:.||.          |...|..:.:.||.:|.
  Fly   129 SGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGM----------GTSGQVFATSALRGLRF 183

Human   449 VRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPD 513
            .::.|:.::.|.....::||..:.|..:||...::..|:|:|..|..||..|.| ....|.:...
  Fly   184 FQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKD-VNDKFSNFAQ 247

Human   514 AFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQ 578
            |.||.|:|:.|||||||.|||..||::.|.||:.|:...|||..::.|.|.....::...:...:
  Fly   248 ALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIR 312

Human   579 LTQNAVS 585
            ..|.|.:
  Fly   313 RRQPAAT 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNA4	NP_002224.1	K_channel_TID	1..>37	CDD:429748
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..148
		BTB_POZ	176..303	CDD:453885	18/99 (18%)
		Ion_trans	306..570	CDD:459842	75/277 (27%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	462..475		3/12 (25%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	524..529		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	629..653
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P15385	651..653
KCNQ	NP_788300.3	Ion_trans	72..305	CDD:459842	73/274 (27%)
		KCNQ_channel	<619..719	CDD:460954