DRSC/TRiP Functional Genomics Resources

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Protein Alignment shg and CDH1

DIOPT Version :10

Sequence 1:NP_476722.1 Gene:shg / 37386 FlyBaseID:FBgn0003391 Length:1507 Species:Drosophila melanogaster
Sequence 2:NP_004351.1 Gene:CDH1 / 999 HGNCID:1748 Length:882 Species:Homo sapiens


Alignment Length:1320 Identity:258/1320 - (19%)
Similarity:384/1320 - (29%) Gaps:572/1320 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   242 YFKIDKE-----SGIIYLKRPIDKRPGQSYAIIVR------------AYNVV-----PDPPQDAQ 284
            ||.:|..     .|:|.:|||:.....|.:.::..            ..|.|     |.|.|.:.
Human    68 YFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASV 132

  Fly   285 IEVRIRVVESSIKPPSF--------VNPIDTPIYLKENLKNFTHPIATLRAVSNMPDKPEVIFEL 341
            ..::..::......|..        :.||..|    ||.|. ..|...::..|| .||...:|..
Human   133 SGIQAELLTFPNSSPGLRRQKRDWVIPPISCP----ENEKG-PFPKNLVQIKSN-KDKEGKVFYS 191

  Fly   342 NTGRTEQTNSKNTFVFNQIGNEVTISLGKTLDYEAITDYTL--TMIVRNTHELGTEHQIKIQVED 404
            .||:...|.....|:..:....:.::  :.||.|.|..|||  ..:..|.:.:....:|.|.|.|
Human   192 ITGQGADTPPVGVFIIERETGWLKVT--EPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTD 254

  Fly   405 VNDNIPYYT-EVKSGTILENEPPGTPVMQVRAFDMDGTSANNIVSFELADNREYFTIDPNTGNIT 468
            .|||.|.:| ||..|:::|...|||.||:|.|.|.|.                    |.||.|..
Human   255 QNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADD--------------------DVNTYNAA 299

  Fly   469 ALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQDKYLAERLL 533
            ...|.                                                ..||..|.::.:
Human   300 IAYTI------------------------------------------------LSQDPELPDKNM 316

  Fly   534 EDANTNTEVIEVKAEDEDNASQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRA 598
            ...|.||.||.|                           :.||       ||.|:...|.|.|:|
Human   317 FTINRNTGVISV---------------------------VTTG-------LDRESFPTYTLVVQA 347

  Fly   599 FD----GIYDDYTTVVIKIEDVNDNPPVFKQDYSVTILEETTYDDCILTVEAYDPDIKDRNADQH 659
            .|    |: ....|.||.:.|.|||||:|........:.|...:..|.|::..|.|..:..| ..
Human   348 ADLQGEGL-STTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPA-WE 410

  Fly   660 IVYSIHQNDGNRWT-----IDNSGCLRLVKTLDRDPPNGHKNWQVLIKANDE---DGVGTTVSTV 716
            .||:|..:||.::.     ::|.|.|:..|.||.:.    |...:|..|...   ..|..|.||.
Human   411 AVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEA----KQQYILHVAVTNVVPFEVSLTTSTA 471

  Fly   717 KEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQANDYDDTPGAGNFTFGI--DS----EA 775
             .|||.:.|:|:...|:..|..|...|:...|..:........||......|:.|  |:    |.
Human   472 -TVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEI 535

  Fly   776 TPD---IKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMS 837
            .||   |.|:..:|.:      .|:......|...|..:|:|.|..:....|.|::.||||||..
Human   536 NPDTGAISTRAELDRE------DFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPI 594

  Fly   838 EGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITM-LVHTA 901
            .....|| :..:...|:.      ::.:|           .|||       |:|...|. |.|.|
Human   595 PEPRTIF-FCERNPKPQV------INIID-----------ADLP-------PNTSPFTAELTHGA 634

  Fly   902 EGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQSPD 966
            ...:                                      :|::.:.|:|..|..|:     .
Human   635 SANW--------------------------------------TIQYNDPTQESIILKPK-----M 656

  Fly   967 ALSLKD-RLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQRL 1030
            ||.:.| ::.|.|                :.|:|                               
Human   657 ALEVGDYKINLKL----------------MDNQN------------------------------- 674

  Fly  1031 ENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLM 1095
                                            |..|..:                          
Human   675 --------------------------------KDQVTTL-------------------------- 681

  Fly  1096 RRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQG 1160
                        |..|||| :|..|                      .|...:       .::.|
Human   682 ------------EVSVCDC-EGAAG----------------------VCRKAQ-------PVEAG 704

  Fly  1161 LIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTS 1225
            |                                                      |:..|     
Human   705 L------------------------------------------------------QIPAI----- 710

  Fly  1226 IEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRN 1290
                           ||.               |||                             
Human   711 ---------------LGI---------------LGG----------------------------- 716

  Fly  1291 LTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILLAVVVQKKQKN 1355
                                                   |:|:::.:.|||:.|....|.|:.. 
Human   717 ---------------------------------------ILALLILILLLLLFLRRRAVVKEPL- 741

  Fly  1356 GWHEKDIDDIRETIINYEDEGGGERDTDYDLNVLRTQPFYEEKLYKDPHALQGN-----MRDPND 1415
               ....||.|:.:..|::|||||.|.|:||:.|      ...|...|...:.:     |..|..
Human   742 ---LPPEDDTRDNVYYYDEEGGGEEDQDFDLSQL------HRGLDARPEVTRNDVAPTLMSVPRY 797

  Fly  1416 IP------DIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYL 1474
            :|      :|.:|:.:..:..|.|..|...|.:..:.|||.|:...|||||.|...|.|.::|||
Human   798 LPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYL 862

  Fly  1475 SNFGPRFRKLADMYGEEPSD 1494
            :.:|.||:|||||||....|
Human   863 NEWGNRFKKLADMYGGGEDD 882

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shgNP_476722.1 Cadherin_repeat 93..191 CDD:206637
Cadherin_repeat 200..292 CDD:206637 14/71 (20%)
CA 332..410 CDD:214520 22/79 (28%)
Cadherin_repeat 417..518 CDD:206637 16/100 (16%)
Cadherin_repeat 531..619 CDD:206637 22/91 (24%)
Cadherin_repeat 627..729 CDD:206637 29/109 (27%)
Cadherin_repeat 736..834 CDD:206637 26/106 (25%)
LamG 1127..1294 CDD:238058 10/166 (6%)
CADH_Y-type_LIR 1430..1489 CDD:460041 27/58 (47%)
CDH1NP_004351.1 Cadherin_pro 27..116 CDD:462590 9/47 (19%)
CA_like 158..258 CDD:206635 29/107 (27%)
Cadherin_repeat 266..371 CDD:206637 42/207 (20%)
Cadherin_repeat 379..482 CDD:206637 28/108 (26%)
Cadherin_repeat 492..591 CDD:206637 25/104 (24%)
Cadherin 598..686 CDD:394985 28/272 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 747..767 9/19 (47%)
Required for binding CTNND1 and PSEN1 758..769 7/10 (70%)
Required for binding alpha, beta and gamma catenins 811..882 29/70 (41%)
CADH_Y-type_LIR 818..877 CDD:460041 27/58 (47%)
Blue background indicates that the domain is not in the aligned region.

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