Protein Alignment shg and Cdh8

DIOPT Version :10

• Sequence 1: NP_476722.1
• Gene: shg / 37386
• FlyBaseID: FBgn0003391
• Length: 1507
• Species: Drosophila melanogaster
• Sequence 2: NP_445845.2
• Gene: Cdh8 / 84408
• RGDID: 69286
• Length: 799
• Species: Rattus norvegicus
• Alignment Length: 1263
• Identity: 256/1263 - (20%)
• Similarity: 370/1263 - (29%)
• Gaps: 614/1263 - (48%)

  Fly   315 LKNFTHPIATLRAVSNMPDKPEVIFELNTGRTEQTNSKNTFVFNQIG-------NEVT--ISLGK 370
            |:.|:.|            :|.::..|:|. .:..:.|..::.:..|       |::|  |...|
  Rat    71 LEEFSGP------------EPILVGRLHTD-LDPGSKKIKYILSGDGAGTIFQINDITGDIHAIK 122

  Fly   371 TLDYEAITDYTLTMIV---RNTHELGTEHQIKIQVEDVNDNI------PYYTEVKSGTILENEPP 426
            .||.|...:||||...   .....|....:..|:|:|:|||.      ||:..|...:||
  Rat   123 RLDREEKAEYTLTAQAVDWETNKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSIL----- 182

  Fly   427 GTPVMQVRAFDMD----GTSANNIVSFELADNREYFTIDPNTGNI-TALTTFDREERDFYNVKVI 486
            ||.|..|.|.|.|    |.||..:  :.:.:.:.||:|:|.|..| |||...|||.::.|.|.:.
  Rat   183 GTSVTNVTATDADDPVYGNSAKLV--YSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQ 245

  Fly   487 ASDNSPSSLFDNGEPNRGHQ-------VFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIE 544
            |.|..            ||.       ...:::.|.||:.|.|.|..|... :.||....|.:..
  Rat   246 AKDMG------------GHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFS-VPEDVVLGTAIGR 297

  Fly   545 VKAEDED---NASQILYSIESGNVGDAFKI----GLKTGKITVNQKLDYETITEYELKVRAFD-- 600
            |||.|:|   || |..|.|..|:....|:|    ..:.|.|.:.:.||:||...|.|||.|.:
  Rat   298 VKANDQDIGENA-QSSYDIIDGDGTALFEITSDAQAQDGVIRLRKPLDFETKKSYTLKVEAANIH 361

  Fly   601 --------GIYDDYTTVVIKIEDVNDNPPVFKQ-DYSVTILEETTYDDCILTVEAYDPDIK---- 652
                    |.:.|..||.|.:||. |.||||.. .|.:.:.|....:..|..|.|.||||.
  Rat   362 IDPRFSGRGPFKDTATVKIVVEDA-DEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPI 425

  Fly   653 ----DRNADQHIVYSIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTV 713
                ||:.|....::|:.:||.         :.|...|||:....| |..:         :.|.:
  Rat   426 RFSIDRHTDLERQFNINADDGK---------ITLATPLDRELSVWH-NISI---------IATEI 471

  Fly   714 ---STVKEVTVTLK--DINDNAPFLINEMPVYWQENRNPGHVVQ-LQANDYDDTPGAGNFTFGID 772
               |.:..|.|.:|  |:|||||...:|...:..||..||.|:| :.|.|.||......|.:.:.
  Rat   472 RNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHFFLYSLL 536

  Fly   773 SEA--TPDIKTKFSMDG--DYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVND 833
            .|.  .|:...|.:.|.  ..|..:..|:|:.|:.|.:||.|||||.|..|:.|
  Rat   537 PEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIVISDSGNPPLSSTS----------- 590

  Fly   834 NAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITMLV 898
                                                                             
  Rat   591 ----------------------------------------------------------------- 590

  Fly   899 HTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQ 963
                                                                             
  Rat   591 ----------------------------------------------------------------- 590

  Fly   964 SPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQ 1028
                                                 ||.:|
  Rat   591 -------------------------------------TLTIR----------------------- 595

  Fly  1029 RLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAP 1093
                                                                             
  Rat   596 ----------------------------------------------------------------- 595

  Fly  1094 LMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQID 1158
                             ||.|.:
  Rat   596 -----------------VCGCSN------------------------------------------ 601

  Fly  1159 QGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQR 1223
                                                                       |.::|.
  Rat   602 -----------------------------------------------------------DGVVQS 607

  Fly  1224 TSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCI 1288
            .::|..|            .|||          |.:|.
  Rat   608 CNVEAYV------------LPIG----------LSMGA--------------------------- 623

  Fly  1289 RNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILLAVVVQKKQ 1353
                                                     :|||:.|:.|||:|::..|..::.
  Rat   624 -----------------------------------------LIAILACIILLLVIVVLFVTLRRH 647

  Fly  1354 KNGWHE----KDIDDIRETIINYEDEGGGERDTD-YDLNVLRT----QPFYEEKLYKD-----PH 1404
            ||   |    ||.:|:||.||.|:||||||.||: :|:..|:.    ..|...|..|.     |.
  Rat   648 KN---EPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPR 709

  Fly  1405 ALQGNMRDPNDIPDIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDL 1469
              ||....||.: |:.:|:..:....|.|..|...|.::.|.|||.|:..||||||.|.|.|.|.
  Rat   710 --QGLAPVPNGV-DVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQ 771

  Fly  1470 NFDYLSNFGPRFRKLADMYGEEPSDTDS 1497
            ||||||::||||::|.::|....||.::
  Rat   772 NFDYLSDWGPRFKRLGELYSVGESDKET 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	23/95 (24%)
		Cadherin_repeat	417..518	CDD:206637	32/112 (29%)
		Cadherin_repeat	531..619	CDD:206637	34/104 (33%)
		Cadherin_repeat	627..729	CDD:206637	28/114 (25%)
		Cadherin_repeat	736..834	CDD:206637	31/102 (30%)
		LamG	1127..1294	CDD:238058	9/166 (5%)
		CADH_Y-type_LIR	1430..1489	CDD:460041	30/58 (52%)
Cdh8	NP_445845.2	CA	87..165	CDD:214520	21/78 (27%)
		Cadherin_repeat	171..272	CDD:206637	35/119 (29%)
		Cadherin_repeat	281..387	CDD:206637	35/108 (32%)
		Cadherin_repeat	395..492	CDD:206637	28/115 (24%)
		Cadherin_repeat	499..602	CDD:206637	37/486 (8%)
		CADH_Y-type_LIR	732..790	CDD:460041	30/57 (53%)