DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and FAT4

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_001278232.1	Gene:	FAT4 / 79633	HGNCID:	23109	Length:	4983	Species:	Homo sapiens

Alignment Length:	1380	Identity:	344/1380 - (24%)
Similarity:	561/1380 - (40%)	Gaps:	271/1380 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 DNRKPAFKNCAGY--APKVKEEQPENTYVLTVEAVDPDP---DQVIRYSIVQSPFERPKFFINPS 140
            ::..|.|...:.|  .|::.|...:.|.|.   |.|||.   .||..:...||.:    |.||.:
Human  2868 NDNAPRFSRTSYYLDCPELTEIGSKVTQVF---ATDPDEGSNGQVFYFIKSQSEY----FRINAT 2925

  Fly   141 TGVIFTTHTFDRDEPIHEKFVFVT-------------VQATDNGLPPLDDVCTFNVTIEDINDNA 192
            ||.||.....        |:..||             |.::|.|.|.|....|..:.|.|.||||
Human  2926 TGEIFNKQIL--------KYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNA 2982

  Fly   193 PAFNKARYDESMSENAQPDAVVMTISA-SDFDDGNNSLVEYEILRERDFQYFKIDKESGIIYLKR 256
            |.|.|::|...:::|.:....::.::| .|.|.|.||.|||.|..:.....||:|.::|.|.:..
Human  2983 PQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVAS 3047

  Fly   257 PIDKRPGQSYAIIVRAYNVVPDPPQDAQIEVRIRVVESSIKPPSFVNPIDTPIYLKENLKNFTHP 321
            .:.....|::.|.|.|.: ..:||..:|..|.|.|.|.:...|.|     :..::...:.. :|.
Human  3048 SLISDLNQNFFITVTAKD-KGNPPLSSQATVHITVTEENYHTPEF-----SQSHMSATIPE-SHS 3105

  Fly   322 IATLRAVSNMPDKPEVI-----FELNTGRTEQTNSKNTFVFNQIGNEVTISLGKTLDYEAITDYT 381
            |.::....:..|:...:     :.:::|     |.:..|..|  .:...::|.|.||||....:.
Human  3106 IGSIVRTVSARDRDAAMNGLIKYSISSG-----NEEGIFAIN--SSTGILTLAKALDYELCQKHE 3163

  Fly   382 LTM-------IVRNTHELGTEHQIKIQVEDVNDNIP-YYTEVKSGTILENEPPGTPVMQVRAFDM 438
            :|:       :.|..:     ..:.:.|.|||||.| :.::....|:|||.|.||.|:.:.|.|.
Human  3164 MTISAIDGGWVARTGY-----CSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDA 3223

  Fly   439 D-GTSANNIVSFEL-ADNREYFTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGEP 501
            | ||:|  ::::.: :.:.:.|.||||||.||.....|.|.:..|::.|.|. |.|.      |.
Human  3224 DSGTNA--VIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAF-NVPD------EE 3279

  Fly   502 NRGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDED--NASQILYSIESGN 564
            ........|.:...|::.|.|....|..| :.|.|...|.|.||.|.|.|  ...::.|.|...:
Human  3280 RCSFATVNIQLKGTNEYVPRFVSKLYYFE-ISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNS 3343

  Fly   565 VGDAFKIGLKTGKITVNQKLDYETITEYELKVRA-----FDGIYDDYTTVVIKIEDVNDNPPVFK 624
            ....|:|..|||:|.|:..||.|......|||.|     ..|...|..||.:.:.|.|| ||:|.
Human  3344 RKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFT 3407

  Fly   625 QD-YSVTILEETTYDDCILTVEAYDPD-IKDRNADQHIVYSIHQNDGNRWTID-NSGCLRLVKTL 686
            .: |||.|.|.......:..|.|:|.| |...:...:.:.|  .|:...::|: .:|.:.:...|
Human  3408 LNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGS--GNENGAFSINPQTGQITVTAEL 3470

  Fly   687 DRDP-PNGHKNWQVLIKANDEDGVGTTVSTVKEVTVTLKDINDNAPFL-INEMPVYWQENRNPGH 749
            ||:. |    .:.:.:.|.|......|.|.  .:.|||:|||||.|.| ::|..|  .||:.||.
Human  3471 DRETLP----IYNLSVLAVDSGTPSATGSA--SLLVTLEDINDNGPMLTVSEGEV--MENKRPGT 3527

  Fly   750 VVQ-LQANDYDDTPGAGNFTFGIDSEATPDIKTKFSMD-GDYLHANVQFDREAQKEYFIPIRISD 812
            :|. ||:.|.|..|..|.||:.:.|  |....:.||:. ...|....:.|||...::::.:...|
Human  3528 LVMTLQSTDPDLPPNQGPFTYYLLS--TGPATSYFSLSTAGVLSTTREIDREQIADFYLSVVTKD 3590

  Fly   813 SGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEW 877
            ||||:.|:...:|:.:.|.|||.....:..||:..|....|...:|.|...|.|
Human  3591 SGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPD----------- 3644

  Fly   878 KDLPHDQFRLNPSTGMITML------------VHTAEGEYDLSFVVTEDSMFVPRHS-VDAYVTV 929
               ..|.|..:.::|:.::.            ..:.:|.:||: |::.|.:    || |.:.:.|
Human  3645 ---VLDSFHCSLTSGVTSLFSIPGGTCDLNSQPRSTDGTFDLT-VLSNDGV----HSTVTSNIRV 3701

  Fly   930 VVRELPEEAVDKSGSIRFINVTKEEFISVP--RDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVF 992
            .........||.|..:|         :.||  :||.:...|..   |:::.::|.....: |.::
Human  3702 FFAGFSNATVDNSILLR---------LGVPTVKDFLTNHYLHF---LRIASSQLTGLGTA-VQLY 3753

  Fly   993 TVLQNENHT-LDVRFSAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEES 1056
            :..:..|.| |......:.:.|..|..:.......::.|..:..:::..|:.|.|:....:...|
Human  3754 SAYEENNRTFLLAAVKRNHNQYVNPSGVATFFESIKEILLRQSGVKVESVDHDSCVHGPCQNGGS 3818

  Fly  1057 CTNELHKSSV-------PYMIYSN----------------------------------------- 1073
            |...|..|||       |.:|.:|
Human  3819 CLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLV 3883

  Fly  1074 -------TTSFVG------VNAFVQAQC------------------------VCEAPL----MRR 1097
                   ...|.|      :|..:|:.|                        :||:.:    ...
Human  3884 GGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNP 3948

  Fly  1098 CLNGGSPRYG-ENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGL 1161
            |.||||.:.| ::..|.|..|..|.||||.|..|....|..: |....||..|.::........|
Human  3949 CFNGGSCQSGVDSYYCHCPFGVFGKHCELNSYGFEELSYMEF-PSLDPNNNYIYVKFATIKSHAL 4012

  Fly  1162 IMYLGPLNF-NPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTS 1225
            ::|    |: |.....::|||||:.......:.:.|||..::  ..:|.|:|..:. .:|.:|..
Human  4013 LLY----NYDNQTGDRAEFLALEIAEERLRFSYNLGSGTYKL--TTMKKVSDGHFH-TVIARRAG 4070

  Fly  1226 I--EMTVDNCRLST----CQTLGAPIGPNEFLNVNA-PLQLGG----TPVDLEQLGRQLNWTHVP 1279
            :  .:|||:|..:.    |......:..:..|:|.. .:.:||    .|: |::.|      ||.
Human  4071 MAASLTVDSCSENQEPGYCTVSNVAVSDDWTLDVQPNRVTVGGIRSLEPI-LQRRG------HVE 4128

  Fly  1280 NQKGFFGCIRNLTIN 1294
            :. .|.|||....:|
Human  4129 SH-DFVGCIMEFAVN 4142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637	32/115 (28%)
		Cadherin_repeat	200..292	CDD:206637	26/92 (28%)
		CA	332..410	CDD:214520	19/89 (21%)
		Cadherin_repeat	417..518	CDD:206637	33/102 (32%)
		Cadherin_repeat	531..619	CDD:206637	31/94 (33%)
		Cadherin_repeat	627..729	CDD:206637	28/104 (27%)
		Cadherin_repeat	736..834	CDD:206637	32/99 (32%)
		LamG	1127..1294	CDD:238058	42/178 (24%)
		Cadherin_C	1358..1489	CDD:279398
FAT4	NP_001278232.1	Cadherin_repeat	48..131	CDD:206637
		Cadherin_repeat	139..246	CDD:206637
		Cadherin_repeat	254..349	CDD:206637
		Cadherin_repeat	364..471	CDD:206637
		Cadherin_repeat	479..577	CDD:206637
		Cadherin_repeat	588..685	CDD:206637
		Cadherin_repeat	693..789	CDD:206637
		Cadherin_repeat	798..889	CDD:206637
		Cadherin_repeat	899..992	CDD:206637
		Cadherin_repeat	1000..1096	CDD:206637
		Cadherin_repeat	1105..1206	CDD:206637
		Cadherin_repeat	1215..1311	CDD:206637
		Cadherin_repeat	1321..1416	CDD:206637
		Cadherin_repeat	1428..1525	CDD:206637
		Cadherin_repeat	1540..1622	CDD:206637
		Cadherin_repeat	1634..1736	CDD:206637
		Cadherin_repeat	1747..1837	CDD:206637
		Cadherin_repeat	1845..1940	CDD:206637
		Cadherin_repeat	1948..2047	CDD:206637
		Cadherin_repeat	2057..2150	CDD:206637
		Cadherin_repeat	2159..2254	CDD:206637
		Cadherin_repeat	2263..2360	CDD:206637
		Cadherin_repeat	2369..2464	CDD:206637
		Cadherin_repeat	2472..2559	CDD:206637
		Cadherin_repeat	2573..2667	CDD:206637
		Cadherin_repeat	2675..2771	CDD:206637
		Cadherin_repeat	2778..2870	CDD:206637	0/1 (0%)
		Cadherin_repeat	2878..2981	CDD:206637	32/117 (27%)
		Cadherin_repeat	2990..3085	CDD:206637	28/95 (29%)
		Cadherin_repeat	3095..3192	CDD:206637	19/109 (17%)
		Cadherin_repeat	3201..3295	CDD:206637	32/102 (31%)
		Cadherin_repeat	3305..3402	CDD:206637	32/97 (33%)
		Cadherin_repeat	3410..3508	CDD:206637	28/105 (27%)
		Cadherin_repeat	3516..3612	CDD:206637	32/99 (32%)
		EGF_CA	3864..3900	CDD:238011	2/35 (6%)
		EGF_CA	3902..3938	CDD:238011	3/35 (9%)
		EGF_CA	3941..3976	CDD:238011	11/34 (32%)
		LamG	3979..4142	CDD:238058	42/178 (24%)
		EGF	4168..4198	CDD:278437
		LamG	4247..4368	CDD:238058
		EGF_CA	4431..4465	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910