DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and fat2

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	XP_001920058.2	Gene:	fat2 / 568468	ZFINID:	ZDB-GENE-111031-1	Length:	4342	Species:	Danio rerio

Alignment Length:	1411	Identity:	341/1411 - (24%)
Similarity:	546/1411 - (38%)	Gaps:	306/1411 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KRKCRDLGRRLIPARLLLGVIVAISLLSPALALHSPPDKNFSGDNRKPAFKNCAGYAPKVKEEQP 102
            |.|.||.|.....:    .|.|.:.::.|.:.|              |.|.... |:....|:.|
Zfish  2654 KVKARDGGFPFYNS----SVPVQVKVVPPEIIL--------------PRFTEPL-YSFSASEDLP 2699

  Fly   103 ENTYVLTVEAVDPDPDQVIRYSIVQ-SPFERPK---FFINPSTGVIFTTHTFDRDEPIHEKF--- 160
            ....:.||:|   |.|..:.||:|. :..:..|   |.|:...|.:...:..|     |||.
Zfish  2700 IGYEIGTVKA---DADMPLIYSLVNGNTLDSNKELSFAIDKDGGTVVLQNNID-----HEKTKMY 2756

  Fly   161 -VFVTVQATDNGLPPLDDVCTFNVTIEDINDNAPAFNKARYDESMSENAQPDAVVMTISASDFDD 224
             :.|..|...|| ..:..:.:.::.::|:|||.|.|....|...::||......|:.::|:|.|.
Zfish  2757 KIDVIAQGNHNG-TNVASLVSVHIEVQDVNDNKPMFEADTYKAFLAENLPSGTTVIQVTANDADA 2820

  Fly   225 GNNSLVEYEILRERD--FQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPDPPQDAQIEV 287
            ..|..|.|.:..|.|  ...|.||.::|.|...:..|....|.:...|.|.:......|.|.:.|
Zfish  2821 NINGEVSYTLEPESDDIGDMFAIDSQTGWITTLKEADSETKQLHRFFVVATDHGDALKQSASVLV 2885

  Fly   288 RIRVVESSIKPPSFVNPIDTPIYLKENLKNFTHP---IATLRAVSN--MPDKPEVIFELNTGRTE 347
            .:.:.:.:..||.|..    .:|....|:| :.|   |.||.....  ..:..:::..:..|
Zfish  2886 EVTLTDENDNPPQFTE----ELYQGSILEN-SRPGENIVTLTTADKDVSAENRQIVCYITDG--- 2942

  Fly   348 QTNSKNTFVFNQIGNEVTISLGKTLDYEAITDYTLTMIVRNTHELGTEHQIKIQVEDVNDNIPY- 411
              :....|....:|.|.|:.....||.|....||| .|:.......|...:::.|.|:|||.|:
Zfish  2943 --DPLGQFSVTAVGEEWTVISKSPLDREDKDKYTL-KIIATDGRFQTSANVEVHVLDLNDNSPFC 3004

  Fly   412 ----YTEVKSGTILENEPPGTPVMQVRAFDMD-GTSANNIVSFEL-ADNREYFTIDPNTGNITAL 470
                |||    .::||...|..::::.|.|.| ||  |..|||.| ..|.:.|.:||.||.:..|
Zfish  3005 EQLQYTE----AVMENSSSGKVILKISASDPDIGT--NGQVSFTLHGPNADKFHLDPKTGELFTL 3063

  Fly   471 TTFDREERDFYNVKVIA-------------------SDNSPS--------SLFDN---------- 498
            ...|||....|::.|.|                   :||.|.        ::|||
Zfish  3064 AVLDREREKEYDLVVKATDGGGRSCQADVTLMVQDMNDNPPQFSTSHYEVTVFDNTTIRTPIAVI 3128

  Fly   499 --GEPNRG----------------------HQVFRI--SIGDK---------------------- 515
              .:|:.|                      ..|.|:  |:.|:
Zfish  3129 YAKDPDTGINSEVRYSLQGADSGFFSLDEISGVLRLERSLADETKSTYEMKVKATDRGLPRHLFS 3193

  Fly   516 -----------NDHKPHFQQDKYLAERLLEDANTNTEVIEVKA--EDEDNASQILYSIESGNVGD 567
                       :|::|.|...:| :.::.|.:...:|||.|.|  :|......:.|||.|||...
Zfish  3194 FAMITVHVVILSDYQPLFLSSEY-SVQIAESSQVGSEVISVSALTKDATENEPVRYSIISGNEDG 3257

  Fly   568 AFKIGLKTGKITVNQKLDYETITEYELKVRAFDG--IYDDYTTVVIKIEDVNDNPPVF-KQDYSV 629
            .|.|...||.::|...||:|...||.|.|....|  :..|...|:|.|.||||||||| :..||.
Zfish  3258 RFMINPVTGLLSVKAALDFERCREYYLSVEGARGKPLLSDIAMVIINITDVNDNPPVFNRSSYST 3322

  Fly   630 TILEETTYDDCILTVEAYDPDIKDRNADQHIVYSIHQND-GNRWTID-NSGCLRLVKTLDRDPPN 692
            .|.|:.:..:..|.|.|.|.|....|   .|:|||...| ..:::|| .:|.:.|...|||:...
Zfish  3323 VIPEDISPGEMALQVRAIDLDGPPNN---FIIYSIVSGDPKQQFSIDPRTGFITLRSMLDREEIT 3384

  Fly   693 GHKNWQVLIKANDEDGVGTTVSTVKEVTVTLKDINDNAPFL--INEMPVYWQENRNPGH-VVQLQ 754
               ::.:.::|.||.  ...:|:..:||||:.|:|||.|..  ||...:. ||....|. ::||.
Zfish  3385 ---HYSLTVQAADEG--DPPLSSAVQVTVTVSDVNDNPPMFSKINHSLIV-QEGEAVGSGILQLL 3443

  Fly   755 ANDYDDTPGAGNFTFGIDSEATPDIKTKFSMD-GDYLHANVQFDREAQKEYFIPIRISDSGVPRQ 818
            ..|.|.......|:|.|.| ...|  ..|.:| |..|..:.|..|..:.::.:.|:::|||.|..
Zfish  3444 VTDRDTPQNGPPFSFHIVS-GNED--RSFHIDQGGLLSVSSQLRRRGKPQHLLKIQVTDSGHPPL 3505

  Fly   819 SAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHD 883
            |::.::.:.|.:.:....:.....|||....|...::.|.::...|.|..|:    ..:|.:...
Zfish  3506 SSICVVKINITEQSRYPPTVNPLEIFITTAGGPILKSVISKLHATDQDPQDV----LSYKLVSEG 3566

  Fly   884 Q----FRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGS 944
            |    |.::...|.|.:..:...|.|.|:..||:.     :.|:.|.|.|.|....::.:|:..:
Zfish  3567 QDKGLFSVDTVDGKIVVEKNLDPGLYHLNVSVTDG-----KFSIWAGVKVHVWAATQQNLDQGFT 3626

  Fly   945 IRFINVTKEEFISVPRDFQSPDALSLKDR---LQLSLAKLFNTSVSNVDVFTVLQNEN----HTL 1002
            ::...::.|||:|              |.   ||.|||:..|.....:.:.::.|..|    ..|
Zfish  3627 LQLAGISAEEFVS--------------DHWRGLQRSLAQELNIPRQELHIASLQQQPNSVNTEVL 3677

  Fly  1003 DVRFSAHGSPYYAP-EKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSV 1066
            .||.:..||....| ::|.|:::    .:|:.|.|.:|.:..|.|:      ...|.....|::|
Zfish  3678 LVRRAQDGSVKSVPVQRLTGVLS----TVEDTLGLNVLRLKHDGCV------GAGCPPRGCKNTV 3732

  Fly  1067 PYMIYSNTTSFVGVNAFVQAQCVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFY 1131
             .|.....:::....                 :|..:|::....:|.|.:.         :|.|.
Zfish  3733 -VMRQGRMSNYATAR-----------------MNFITPQHSWESMCTCNES---------AVRFD 3770

  Fly  1132 GSGYA--FYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFNPLLAISDFLALE------LDNGY 1188
            |.||.  .|....|..|..:||.:......|.:|.....::..|..:...|.|.      |..|.
Zfish  3771 GKGYLKYLYHMEEAKENFHLSLRLKTSAADGTVMATNASDWGTLELVDKELWLRYRCGNMLSAGL 3835

  Fly  1189 PVLTVDYGSGAIRIRHQHIKM-VADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGAPI----GPN 1248
            .|.......|    |..|:.: |.|.|.:|.|....|:..:....||||  ...||.:    .||
Zfish  3836 QVANYPVADG----RWHHVSLDVNDTTLRLTIDSSHTNSVVLPQPCRLS--HPGGALVLASSNPN 3894

  Fly  1249 EFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTIN 1294
                           .|.|:|             ||.||:.::..|
Zfish  3895 ---------------TDAERL-------------GFTGCLESVHFN 3912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637	25/105 (24%)
		Cadherin_repeat	200..292	CDD:206637	24/93 (26%)
		CA	332..410	CDD:214520	18/77 (23%)
		Cadherin_repeat	417..518	CDD:206637	38/198 (19%)
		Cadherin_repeat	531..619	CDD:206637	33/91 (36%)
		Cadherin_repeat	627..729	CDD:206637	32/103 (31%)
		Cadherin_repeat	736..834	CDD:206637	25/99 (25%)
		LamG	1127..1294	CDD:238058	42/179 (23%)
		Cadherin_C	1358..1489	CDD:279398
fat2	XP_001920058.2	Cadherin_repeat	40..145	CDD:206637
		Cadherin_repeat	154..249	CDD:206637
		Cadherin_repeat	369..456	CDD:206637
		Cadherin_repeat	464..562	CDD:206637
		Cadherin_repeat	572..662	CDD:206637
		Cadherin_repeat	721..816	CDD:206637
		Cadherin_repeat	825..921	CDD:206637
		Cadherin_repeat	929..1026	CDD:206637
		Cadherin_repeat	1038..1133	CDD:206637
		Cadherin_repeat	1141..1237	CDD:206637
		Cadherin_repeat	1246..1334	CDD:206637
		Cadherin_repeat	1352..1442	CDD:206637
		Cadherin_repeat	1451..1548	CDD:206637
		Cadherin_repeat	1556..1649	CDD:206637
		Cadherin_repeat	1662..1752	CDD:206637
		Cadherin_repeat	1760..1865	CDD:206637
		Cadherin_repeat	1889..1957	CDD:206637
		Cadherin_repeat	1972..2064	CDD:206637
		Cadherin_repeat	2074..2162	CDD:206637
		Cadherin_repeat	2174..2266	CDD:206637
		Cadherin_repeat	2274..2370	CDD:206637
		Cadherin_repeat	2378..2468	CDD:206637
		Cadherin_repeat	2478..2574	CDD:206637
		Cadherin_repeat	2582..2668	CDD:206637	5/17 (29%)
		Cadherin_repeat	2690..2787	CDD:206637	25/105 (24%)
		Cadherin_repeat	2795..2895	CDD:206637	24/99 (24%)
		Cadherin_repeat	2904..3000	CDD:206637	23/102 (23%)
		Cadherin_repeat	3008..3102	CDD:206637	29/99 (29%)
		Cadherin_repeat	3110..3206	CDD:206637	9/95 (9%)
		Cadherin_repeat	3215..3311	CDD:206637	34/96 (35%)
		Cadherin_repeat	3319..3416	CDD:206637	32/104 (31%)
		Cadherin_repeat	3429..3516	CDD:206637	24/90 (27%)
		Cadherin_repeat	3542..3613	CDD:206637	18/79 (23%)
		LamG	3766..3912	CDD:238058	42/179 (23%)
		EGF_CA	3941..3978	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910