Protein Alignment shg and cdh7a

DIOPT Version :10

• Sequence 1: NP_476722.1
• Gene: shg / 37386
• FlyBaseID: FBgn0003391
• Length: 1507
• Species: Drosophila melanogaster
• Sequence 2: XP_005163459.1
• Gene: cdh7a / 567704
• ZFINID: ZDB-GENE-061019-3
• Length: 801
• Species: Danio rerio
• Alignment Length: 1245
• Identity: 248/1245 - (19%)
• Similarity: 366/1245 - (29%)
• Gaps: 598/1245 - (48%)

  Fly   333 DKPEVIFELNTGRTEQTNSKNTFVFNQIG---------NEVTISLGKTLDYEAITDYTLTMIVRN 388
            |:|..:.:|::. .::...|..:|.|..|         |...|...|.||.|....|||....|:
Zfish    74 DEPLYVGKLHSD-VDKGEGKVKYVLNGEGATSIFTIDENTGDIHATKRLDREEQAYYTLRAQARD 137

  Fly   389 ---THELGTEHQIKIQVEDVNDNIPYYTE-VKSGTILENEPPGTPVMQVRAFDMD----GTSANN 445
               ...:..|.:..|:|:|:|||.|.:.: ..:..:.|..|.||.|::|:|.|.|    |.||.
Zfish   138 RATNLPVEPESEFVIKVQDINDNEPKFLDGPYNAQVPEMSPVGTSVVEVKATDADDPTYGNSAR- 201

  Fly   446 IVSFELADNREYFTIDPNTGNI-TALTTFDREERDFYNVKVIASDNSPSSLFDNGEPN--RGHQV 507
             |.:.:.:.:.||:::|.||.: |||...|||.||.|.:.:.|.|..       |:..  .|...
Zfish   202 -VVYSILEGQPYFSVEPKTGIVRTALPNMDREARDQYLLVIQAKDMV-------GQMGGLSGTTS 258

  Fly   508 FRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDED---NASQILYSIESGNVGDAF 569
            ..:::.|.||:.|.|.:..| ...:.|.....:.|.::||.|.|   ||......||...:| .|
Zfish   259 VTVTLTDVNDNPPRFSRKSY-QFAVPESLPVASVVAKIKALDSDIGPNAEMDYRIIEGDGLG-VF 321

  Fly   570 KI----GLKTGKITVNQKLDYETITEYELKVRAFD----------GIYDDYTTVVIKIEDVNDNP 620
            ::    ..:.|.||:.:.||:||.:.|.||:.|.:          |.:.|...|.:.:|:| |.|
Zfish   322 RVTTDKDTQEGVITLQKNLDFETKSSYTLKIEASNRNIDPRFLSQGPFSDTAMVRLTVENV-DEP 385

  Fly   621 PVFKQDYSVTILEETT-YDDCILTVEAYDPDIK--------DRNADQHIVYSIHQNDGNRWTIDN 676
            |||....|..::.|.. ....|.||.|.|||..        |||.|....::|.         ..
Zfish   386 PVFSSPLSKMVVSEAAKVGTMIGTVSAMDPDTTNSPIRYSIDRNTDLERFFNIE---------ST 441

  Fly   677 SGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYW 741
            :|.:...|.|||:....|....:.|::.|...||..|:     .:|:.|||||||....|...:.
Zfish   442 TGVISTAKPLDREANAVHNITILAIESMDPSQVGKGVA-----LITVMDINDNAPVFAIEYETFL 501

  Fly   742 QENRNPGHVVQ-LQANDYDDTPGAGNFTFGIDSEA--------------TPDIKTKFSMDGDYLH 791
            .|:..||.|:: :.|.|.|:.|....|.|.:.:|.              |..:.||.|
Zfish   502 CESVGPGQVIETISAVDKDEPPSGHRFFFSLTAETAGNMNFTLRDNKDNTASVLTKRS------- 559

  Fly   792 ANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETD 856
               .|.|..|..|.:|:.|.|||.|
Zfish   560 ---GFQRRDQSMYRLPVLIVDSGTP---------------------------------------- 581

  Fly   857 IGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRH 921
                                                                             
Zfish   582 ----------------------------------------------------------------- 581

  Fly   922 SVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSV 986
                                                         |||
Zfish   582 ---------------------------------------------ALS----------------- 584

  Fly   987 SNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKF 1051
                       ..:||.:|
Zfish   585 -----------STNTLSIR---------------------------------------------- 592

  Fly  1052 KCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLMRRCLNGGSPRYGENDVCDC-I 1115
                                                                       |||| .
Zfish   593 -----------------------------------------------------------VCDCDP 598

  Fly  1116 DGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFNPLLAISDFL 1180
            ||                                    |||
Zfish   599 DG------------------------------------TPQ------------------------ 603

  Fly  1181 ALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGAPI 1245
                                                                    :|.|
Zfish   604 --------------------------------------------------------SCGT----- 607

  Fly  1246 GPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNLGMPSVFRNID 1310
                                                                             
Zfish   608 ----------------------------------------------------------------- 607

  Fly  1311 SGCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILLAVVVQKKQKNGWHEKDID-DIRETIINYED 1374
                  .|...|.|:....:|||:.|:..||:::|.:|..:::|......|.| |:||.|:.|:|
Zfish   608 ------EAFMLSAGLSTGALIAILACIITLLVLVLLIVTMRRRKKEPLILDEDRDVRENIVRYDD 666

  Fly  1375 EGGGERDTD-YD------LNVLRTQPFYEEKLYKD--PH--ALQGNMRDPNDI-PD---IADFLG 1424
            |||||.||: :|      |||:|     :.|..:|  |.  .|..:...|..| ||   ..:|:.
Zfish   667 EGGGEEDTEAFDMVALRNLNVVR-----DSKARRDVTPEVPTLYCSRPPPYKITPDNGIFREFIW 726

  Fly  1425 DKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYG 1489
            |:.::.|.|..|...|.::.||:||.|:...|||||.|.:.|.:.|:||||::|||||||||:||
Zfish   727 DRLKDADVDPSAPPYDSLQTYAFEGSGSVAESLSSLDSLSTDSEQNYDYLSDWGPRFRKLADLYG 791

  Fly  1490 EEPSDTDSNV 1499
            ...|   ||:
Zfish   792 HGDS---SNI 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	24/88 (27%)
		Cadherin_repeat	417..518	CDD:206637	33/107 (31%)
		Cadherin_repeat	531..619	CDD:206637	28/104 (27%)
		Cadherin_repeat	627..729	CDD:206637	29/110 (26%)
		Cadherin_repeat	736..834	CDD:206637	26/112 (23%)
		LamG	1127..1294	CDD:238058	5/166 (3%)
		CADH_Y-type_LIR	1430..1489	CDD:460041	30/58 (52%)
cdh7a	XP_005163459.1	CA	84..162	CDD:214520	21/78 (27%)
		Cadherin_repeat	168..269	CDD:206637	33/109 (30%)
		Cadherin_repeat	277..384	CDD:206637	29/109 (27%)
		Cadherin_repeat	397..489	CDD:206637	28/105 (27%)
		Cadherin_repeat	496..595	CDD:206637	33/391 (8%)
		CADH_Y-type_LIR	732..791	CDD:460041	30/58 (52%)