DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shg and fat1b

DIOPT Version :9

Sequence 1:NP_476722.1 Gene:shg / 37386 FlyBaseID:FBgn0003391 Length:1507 Species:Drosophila melanogaster
Sequence 2:XP_021328497.1 Gene:fat1b / 565591 ZFINID:ZDB-GENE-130530-563 Length:4503 Species:Danio rerio


Alignment Length:1632 Identity:366/1632 - (22%)
Similarity:592/1632 - (36%) Gaps:499/1632 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 HSPPDKNFSGDNRKPAFKNCAGYAPKVKEEQPENTYVLTVEAVDPDPDQVIRYS-IVQSPFERPK 134
            |||   :|:.|.          |..::.|..|..|.|..|||:|.||.:..:.: .:.:...|.|
Zfish  2512 HSP---SFTQDE----------YLIELAENSPVGTLVGQVEAIDEDPGKYGQLTFFIMNDIARDK 2563

  Fly   135 FFINPSTGVIFTTHTFDRDEPIHEKFVFVTVQATDNGLPPLDDVCTFNVTIEDINDNAPAFNKAR 199
            |.|| ..|.|:|..:|||:.| .||.:.:::.|.|.|  .|...|...|.:.|:|||:|.|..:.
Zfish  2564 FNIN-EDGQIYTEESFDRENP-EEKIIRISLMAKDGG--GLLGFCNVIVILSDVNDNSPKFKHSE 2624

  Fly   200 YDESMSENAQPDAVVMTISASDFDDGNNSLVEYEILRERDFQYFKIDKESGIIYLKRPIDKRPGQ 264
            |..::..:|.....|:..:|.|.|:|:|:.:.|.|  |.|..:|:|...||.|..|..:......
Zfish  2625 YKVTVPRDAPSSTTVIKTTAVDEDEGSNADIVYTI--ESDIDHFEIHSLSGAIVTKESLIGLENG 2687

  Fly   265 SYAIIVRAYNVVPDPPQDAQIEVRIRVVESSIKPPSFVNPIDTPIYLKENLKNFTHPIATLRAVS 329
            .|:..|:|.: ...||:.:.|.|.||:|......|.|..| ...:.|.|:|     .:.|...:.
Zfish  2688 LYSFFVKAKD-SGSPPKQSIIPVSIRIVPPETSIPKFAEP-SLWLELSEDL-----AVGTEMDIF 2745

  Fly   330 NMPDKPEVIFELNTGRTEQTNSKNTFVFNQIGNEVTISLGKTLDYEAITDYTLTMIVRNTH---E 391
            ...::..||:.|..|.|.::|..:.|..:....::.::  |.||||.|..|.|.:.||:..   |
Zfish  2746 QAENELSVIYSLVGGNTPESNKHDVFAIDSTTGKLILT--KRLDYETIKWYHLAVQVRDVKDDME 2808

  Fly   392 LGTEHQIKIQVEDVNDNIPYYTEVK-SGTILENEPPGTPVMQVRAFDMD---------------- 439
            :.:...:.:.::|||||.|.:...: ...|.||.|.||.|:||:|.|:|                
Zfish  2809 MISTVDVSVHLKDVNDNSPQFESFRYQSCIAENLPKGTSVVQVKATDLDSWLNGQITYALHENQQ 2873

  Fly   440 -----------------------------------------------GTSANNIVSFELADN--- 454
                                                           ||:...:...:..||   
Zfish  2874 PPDVLQLFSVNSETGWITTLMEIDREKTDQYRITVVATDGAQGLQMTGTTVVEVTVVDTNDNPPL 2938

  Fly   455 ----------------------------------------------------------------- 454
                                                                             
Zfish  2939 FTEAVFKGAVREDESTPGTVVTILSYVDSDSDEVNRRFNCFITGGDPQGLFDVKHTDGVWVVAVS 3003

  Fly   455 ----------------------------------------------------------------- 454
                                                                             
Zfish  3004 KTLDREERDFYLLNITATDGTFVAKAAVEITVLDANDNSPVCEKDVYAQAVPEDVLIGKHILQVS 3068

  Fly   455 --------------------REYFTIDPNTGNITALTTFDREERDFYNVKV-------------- 485
                                .|.||||..||.:..|.|.|||..|.||:.|              
Zfish  3069 ATDADIQSNAEITYQLSGSGAESFTIDSKTGAVKTLATLDREVTDVYNLTVRAVDKDNHFCQASL 3133

  Fly   486 -----IASDNSPS--------SLFDNGEPN----------------------------------- 502
                 .|:||:|.        |::.|.:|.                                   
Zfish  3134 LITVEDANDNAPKFTSDPHHVSIYQNTQPGTYVARLEAFDADIGMNGKIRYSFEDSAGGLFSIEE 3198

  Fly   503 ---------------RGHQVFRI------------SIG-------DKNDHKPHFQQDKYLAERLL 533
                           :...|.|:            |:|       |.|||.|.|::.:|:: .:.
Zfish  3199 SSGIISLERSLDKQMKAMHVLRVRATDQGFPHRLSSLGSVLVTVLDANDHPPVFERREYIS-TVP 3262

  Fly   534 EDANTNTEVIEVKAEDEDN--ASQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKV 596
            ||....|::::|.|..:|.  .||..||..|||...||:|..:||.|.|.:.||||..:::.|.|
Zfish  3263 EDVTIGTKLLKVFASSKDRQMTSQTTYSFSSGNEQGAFRIDSQTGDIFVMEPLDYEESSQHYLTV 3327

  Fly   597 RAFDG---IYDDYTTVVIKIEDVNDNPPVFKQD-YSVTILEETTYDDCILTVEAYDPDIKDRNAD 657
            :|..|   ...|..||.|.::|:|||.|||.|. ||..:.|:|.....:|||.|.|   .|...:
Zfish  3328 KATVGGKQSLSDMATVSIHLQDINDNSPVFSQKIYSAVVSEDTRLASTVLTVLAND---LDGPLN 3389

  Fly   658 QHIVYSIHQ-NDGNRWTIDN-SGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTV-STVKEV 719
            ..|.|||.: |....:.:|. ||.|:|.:.|||:..   .::.:.:.|:|.   |:.: |....:
Zfish  3390 NQIRYSIEESNQSCPFIMDAVSGELQLARQLDREMV---ASYMLTVMASDS---GSPLKSDSAAI 3448

  Fly   720 TVTLKDINDNAP-FLINEMPVYWQENRNPG-HVVQLQANDYDDTPGAGNFTF---GIDSEATPDI 779
            .:.:.|:|||.| |......:..|||...| .|:||...|.|.......|:|   |:  ||.|  
Zfish  3449 NIAVSDVNDNPPVFSQANYSLIIQENLPSGTSVLQLNVTDNDSLHNGPPFSFILIGV--EANP-- 3509

  Fly   780 KTKFSMDGDYLHANVQFDREAQK-EYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSRI 843
               ||:|...|   |:......| :|.:.:::||:|.|.|.:|:.:.:::...:....|.....|
Zfish  3510 ---FSIDQQGL---VKTAGPLTKGQYTLQVQVSDNGKPPQKSVTSITVLVAQASMFPPSVFPLEI 3568

  Fly   844 FIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQ--FRLNPSTGMITMLVHT------ 900
            ||...:.|.....:|::...|.|:              ||:  |.|:|.:..:..::.|      
Zfish  3569 FIILLEDEYSGGTLGKIHATDQDE--------------HDKLAFSLDPQSHSLFSIIGTDGRLLA 3619

  Fly   901 ----AEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVP-R 960
                ..|.|.|: |...|..|    ||.:.|.|.|.::.|:.:|.|.||||..:|.|:||... :
Zfish  3620 REGLDVGHYQLN-VSVSDGHF----SVSSIVKVNVLQVTEQMLDSSISIRFAGITTEDFIQDHWK 3679

  Fly   961 DFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNE--NHTLDVRFSAHGSPYY--------A 1015
            :||         ::..|:|.....:::.:.    ||:.  ...|||..      |:        |
Zfish  3680 NFQ---------KMLRSVAGARRGAINLIS----LQSAGFGDGLDVLL------YFERPRRGAGA 3725

  Fly  1016 PEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEE-SCTNELHKSSVPYMIYSNT-TSFV 1078
            .|.|:..::.::..::....|.::.|....||  ..:|.: .|...|..:......||.. .|::
Zfish  3726 LEALSQKISSSRGAIKEMTGLHVVRVLNSRCL--SSECPDGKCRRVLLFNQTTMGAYSTARVSYI 3788

  Fly  1079 GVNAFVQAQCVC-EAPLMRR---CLNGGSPRYGENDVCDCIDGF---------TGP---HCE-LV 1126
            .....:.|:|:| ::..:::   |:|...|     :..:|:.||         ||.   .|. ..
Zfish  3789 TPRHHMTAKCLCTDSKCLKQEYTCVNSTCP-----EGYECVSGFGQDKHSCICTGAAKVKCSGGS 3848

  Fly  1127 SVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVL 1191
            |:.|..|.|..|..:.:....|::|::.....:|.||.......:.|......|..:.|.|:...
Zfish  3849 SMTFSESSYIKYSLMESMKGLKLTLKLKTLSTEGTIMLARGTGHSILEIAGGRLQFQFDCGWGFA 3913

  Fly  1192 TVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCRLSTCQ---TLGAPIGPNEFLNV 1253
            ||..          |..:|.|..:.:      ..:|:..:..||...|   ..|...||...||:
Zfish  3914 TVSV----------HSVLVNDGQWHM------AELEVKGNYARLVLDQLHSASGIAPGPLHCLNL 3962

  Fly  1254 NAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVA 1318
            ...:.|||....|....|:    ::|......||:.::.:|....:|         |||....|.
Zfish  3963 GEQVVLGGHAQHLGSRRRR----NLPASNSLQGCMDSVLLNGHRLSL---------DSGGPLGVT 4014

  Fly  1319 VAFSFGI 1325
            :....|:
Zfish  4015 IEDMVGV 4021

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shgNP_476722.1 Cadherin_repeat 93..191 CDD:206637 33/98 (34%)
Cadherin_repeat 200..292 CDD:206637 27/91 (30%)
CA 332..410 CDD:214520 23/80 (29%)
Cadherin_repeat 417..518 CDD:206637 45/412 (11%)
Cadherin_repeat 531..619 CDD:206637 34/92 (37%)
Cadherin_repeat 627..729 CDD:206637 29/104 (28%)
Cadherin_repeat 736..834 CDD:206637 28/102 (27%)
LamG 1127..1294 CDD:238058 36/169 (21%)
Cadherin_C 1358..1489 CDD:279398
fat1bXP_021328497.1 Cadherin_repeat 45..150 CDD:206637
Cadherin_repeat 159..259 CDD:206637
E_set 272..359 CDD:324323
Cadherin_repeat 377..467 CDD:206637
Cadherin_repeat 476..573 CDD:206637
Cadherin_repeat 584..673 CDD:206637
Cadherin_repeat 729..826 CDD:206637
Cadherin_repeat 834..931 CDD:206637
Cadherin_repeat 939..1036 CDD:206637
Cadherin_repeat 1050..1143 CDD:206637
Cadherin_repeat 1151..1249 CDD:206637
Cadherin_repeat 1273..1347 CDD:206637
Cadherin_repeat 1365..1477 CDD:206637
Cadherin_repeat 1485..1583 CDD:206637
Cadherin_repeat 1591..1687 CDD:206637
Cadherin_repeat 1696..1786 CDD:206637
Cadherin_repeat 1794..1899 CDD:206637
Cadherin_repeat 1908..1996 CDD:206637
Cadherin_repeat 2008..2102 CDD:206637
Cadherin_repeat 2110..2199 CDD:206637
Cadherin_repeat 2211..2303 CDD:206637
Cadherin_repeat 2311..2410 CDD:206637
Cadherin_repeat 2419..2512 CDD:206637 366/1632 (22%)
Cadherin_repeat 2520..2616 CDD:206637 33/109 (30%)
Cadherin_repeat 2624..2714 CDD:206637 27/92 (29%)
Cadherin_repeat 2730..2825 CDD:206637 25/101 (25%)
Cadherin_repeat 2838..>2915 CDD:206637 12/76 (16%)
Cadherin_repeat 2943..3041 CDD:206637 0/97 (0%)
Cadherin_repeat 3054..3143 CDD:206637 17/88 (19%)
Cadherin_repeat 3153..3248 CDD:206637 9/94 (10%)
Cadherin_repeat 3256..3353 CDD:206637 35/97 (36%)
Cadherin_repeat 3361..3458 CDD:206637 29/105 (28%)
Cadherin_repeat 3467..3553 CDD:206637 28/95 (29%)
Cadherin_repeat 3567..3652 CDD:206637 24/103 (23%)
Laminin_G_2 3881..4001 CDD:308045 30/139 (22%)
EGF 4033..4064 CDD:306513
EGF_CA 4069..4104 CDD:238011
EGF 4109..4139 CDD:306513
EGF_CA 4143..4179 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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